Atostin Tablet

Atostin Tablet 10 mg Overview

Atostin Tablet 10 mg (Lipitor) is a medication used to treat high cholesterol and atherosclerosis. It belongs to the class of drugs known as statins and is available in tablet form. The drug works by inhibiting the production of cholesterol in the body.

Uses For Atostin Tablet 10 mg

Atostin Tablet 10 mg is used to lower "bad" cholesterol (LDL) and triglycerides in the blood, and to increase "good" cholesterol (HDL). It is also used to reduce the risk of heart attack, stroke, and other complications associated with coronary artery disease and atherosclerosis.

Brand Name	Atostin
Type	Tablet
Weight	10 mg
Generic	Atorvastatin Calcium
Manufacturer	Credence Pharmaceuticals Ltd. (Mfg. by: Somatec Pharmaceuticals Ltd.)
Available in	English বাংলা

Mechanism of Action

Atostin Tablet 10 mg works by targeting an enzyme called HMG-CoA reductase. This enzyme is responsible for producing cholesterol, fats, and other lipids in the body. By blocking this enzyme, Atostin Tablet 10 mg is able to reduce the levels of bad cholesterol and other fatty substances in the blood.

How Long Does It Take to Work?

Atostin Tablet 10 mg typically starts to take effect within two to four weeks, however the full effect may take up to 12 weeks. It is important to follow your doctor's instructions and take the medication as prescribed.

Absorption

Atostin Tablet 10 mg is generally well absorbed and the peak plasma concentration is typically achieved within 2 to 4 hours post administration.

Route of Elimination

Atostin Tablet 10 mg is metabolized in the liver and eliminated by the kidneys. Approximately 75% of an oral dose of Atostin Tablet 10 mg is excreted in the feces.

Dosage

Primary hypercholesterolaemia and combined hyperlipidaemia-

Adults: Usually 10 mg once daily; if necessary, may be increased at intervals of at least 4 weeks to max. 80 mg once daily.
Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 20 mg once daily.

Familial hypercholesterolaemia-

Adults: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily (or 40 mg once daily combined with anion-exchange resin in heterozygous familial hypercholesterolaemia).
Child (10-18 years): Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 80 mg once daily.

Prevention of cardiovascular events-

Adults: Initially 10 mg once daily adjusted according to response.

Another guideline:

The patient should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin. The recommended starting dose of Atorvastatin is 10 or 20 mg once daily. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily. The dosage range of Atorvastatin is 10 to 80 mg once daily. Atorvastatin can be administered as a single dose at any time of the day, with or without food. After initiation of Atorvastatin lipid levels should be analyzed within 2 to 4 weeks and dosage adjusted accordingly.

In hypercholesterolemia in Pediatric Patients (10-17 years of age) the recommended starting dose of Atorvastatin is 10 mg/day; the maximum recommended dose is 20 mg/day (doses greater than 20 mg have not been studied in this patient population). Doses should be individualized according to the recommended goal of therapy. Adjustments should be made at intervals of 4 weeks or more.

The recommended dosage of Atostin Tablet 10 mg is 10-80 mg per day. The dose must be determined by your doctor based on your individual needs, and it can be adjusted further based on your response to treatment and lab values. The maximum dose of Atostin Tablet 10 mg should not exceed 80 mg per day.

Administration

Atostin Tablet 10 mg should be taken orally once a day. It can be taken with or without food. It is important to swallow the tablet whole without crushing, splitting, or chewing it.

Side Effects

Common side effects of Atostin Tablet 10 mg include headache, muscle pain, abdominal pain, nausea, vomiting, and diarrhea. Serious side effects may include liver damage, rhabdomyolysis, and an elevation in liver enzymes. If you experience any of these side effects, contact your doctor immediately.

Toxicity

Atostin Tablet 10 mg is generally well tolerated at the recommended dosage. Overdose of Atostin Tablet 10 mg may lead to an elevation of liver enzymes which may cause serious liver damage.

Precautions

Before taking Atostin Tablet 10 mg, tell your doctor if you have any history of liver or kidney disease, alcohol abuse, or if you are pregnant or breastfeeding. Do not stop taking Atostin Tablet 10 mg without consulting your doctor.

Interactions

Atostin Tablet 10 mg may interact with certain other medications, including cyclosporine, niacin, and antacids. Before taking Atostin Tablet 10 mg, be sure to tell your doctor and pharmacist about all other medications you are taking, including herbal remedies and supplements.

Disease Interactions

Atostin Tablet 10 mg may interact with certain diseases or medical conditions, including liver, kidney, or muscle disease, hypothyroidism, and diabetes. Tell your doctor if you have any of these conditions before taking Atostin Tablet 10 mg.

Drug Interactions

Atostin Tablet 10 mg may interact with certain other medications, including cyclosporine, niacin, and antacids. Tell your doctor and pharmacist about all other medications you are taking, including herbal remedies and supplements.

Food Interactions

Atostin Tablet 10 mg may interact with certain foods, including grapefruit and grapefruit juice. Avoid eating grapefruit or drinking grapefruit juice while taking Atostin Tablet 10 mg.

Pregnancy Use

Atostin Tablet 10 mg should not be used by pregnant women unless it is clearly necessary. If it is necessary, the lowest effective dose should be taken. Women should talk to their healthcare provider about the risks and benefits before using the drug.

Lactation Use

Atostin Tablet 10 mg is excreted in breast milk and therefore should be used with caution in nursing women. It is not recommended for women who are breastfeeding unless it is clearly necessary.

Acute Overdose

An overdose of Atostin Tablet 10 mg is unlikely to cause life-threatening symptoms, however it can lead to an elevation of liver enzymes which may cause serious liver damage. If you think you have overdosed, seek medical attention immediately.

Contraindication

Atostin Tablet 10 mg is contraindicated in individuals with active liver disease, hypersensitivity to the drug, or a history of myopathy or rhabdomyolysis. It should also not be used by pregnant women unless it is clearly necessary.

Use Direction

Atostin Tablet 10 mg should be taken orally once a day, with or without food. It is important to swallow the tablet whole without crushing, splitting, or chewing it. It is very important to take at the same time each day and to not skip doses.

Storage Condition

Atostin Tablet 10 mg should be stored at room temperature between 59°F to 86°F (15°C to 30°C). It should be kept away from light and moisture and in a tightly sealed container.

Volume of Distribution

Atostin Tablet 10 mg has a relatively low volume of distribution (~2.6 L/kg). This means that the drug is not widely distributed throughout the body.

Half Life

Atostin Tablet 10 mg has an elimination half life of 14 hours. This means that it takes 14 hours for the drug to be reduced to half of its original concentration in the bloodstream.

Clearance

Atostin Tablet 10 mg has a systemic clearance rate of approximately 18 mL/min/kg. This means that the drug is cleared from the bloodstream at a rate of 18 mL per minute for every kilogram of body weight.

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