Asthmolin Syrup

Introduction

Asthmolin Syrup 2 mg/5 ml, also known as albuterol, is a short-acting bronchodilator medication, and is widely used to treat and prevent wheezing due to asthma, chronic obstructive pulmonary disease (COPD) and other respiratory diseases. It works by helping open the airways in the lungs to make breathing easier. It can also be used to prevent exercise-induced bronchospasm.

Uses

Asthmolin Syrup 2 mg/5 ml medications are used to treat and prevent asthma and other similar respiratory problems like wheezing, shortness of breath and chest tightness. Inhaled Asthmolin Syrup 2 mg/5 ml can also be used to prevent exercise-induced bronchospasm. Asthmolin Syrup 2 mg/5 ml is sometimes also used to relieve severe chest tightness in people with COPD and to treat breathing problems in very premature babies.

Mechanism of Action

Asthmolin Syrup 2 mg/5 ml works by stimulating the Beta2 receptors of the lungs, which relaxes the smooth muscles of the airways. This allows the airways to open up and allows more air into the lungs. As a result, breathing is easier and less strained. Asthmolin Syrup 2 mg/5 ml also binds to the receptors in the skin, which may cause the skin to feel cold or tingly for a short period of time.

How Long Does It Take to Work?

Asthmolin Syrup 2 mg/5 ml medications typically start working within 5 minutes to reduce wheezing and shortness of breath. Maximum benefits of the medication can be felt after 15 to 30 minutes. However, it is important to note that the effects of salbutamol vary from person to person and depend on how severe the asthma or other respiratory disorder is.

Absorption

Inhaled salbutamol is rapidly absorbed into the bloodstream when inhaled through an inhaler device. The maximum concentration of salbutamol in the blood is usually reached about 15-25 minutes after administration.

Route of Elimination

Asthmolin Syrup 2 mg/5 ml is mainly eliminated via metabolism in the liver and also in the kidneys. The elimination half-life of salbutamol is about 4 to 6 hours.

Dosage

• 2-6 years: 2.5 ml syrup, 3-4 times daily
• 6-12 years: 5 ml syrup, 3-4 times daily
• Over 12 years: 5-10 ml syrup, 3-4 times daily (2-4 mg tablet, 3-4 times daily)

• Adults (and the elderly): 0.5 ml-1.0 ml salbutamol up to four times a day. Up to 40mg per day can be given under strict medical direction in the hospital. 0.5-1 ml solution should be diluted to final volume of 2-4 ml with sterile normal saline solution. It will take time about 10 minutes.
• Salbutamol respiratory solution may be used undiluted for intermittent administration. For this 2.0 ml of the solution is placed in the nebulizer and the patient allowed to inhale until bronchodilation is achieved. This usually takes 3-5 minutes.
• Children under 12 years of age: 0.5 ml of the solution diluted to 2.0-4.0 ml with normal saline. Some children may however require higher doses of up to 1.0 ml of the solution. Intermittent treatment may be repeated four times a day.

• Adults & Elderly: 2.5 mg to 5 mg Salbutamol up to 4 times a day. Up to 40 mg/day may be given under strict medical direction in the hospital.
• Children under 12 years: 2.5 mg up to 4 times a day. A higher dose up to 5 mg four times a day may be used if required.

• Salbutamol I.V. infusion solution is used to prepare a solution for continuous intravenous infusion. It should not be injected undiluted. A suitable solution for infusion may be prepared by diluting 5 mL of Salbutamol I.V. infusion solution (1000 mcg/mL) in 500 mL of a chosen i.v. solution to provide a salbutamol concentration of 10 mcg/mL.
• The only recommended diluents are Sodium Chloride Injection, or Sodium Chloride and Dextrose Injection.
• Infusion rates providing 3 to 20 micrograms salbutamol/minute (0.3 to 2ml/minute of the above infusion solution) are usually adequate. Infusion rates can be started at 5 mcg of salbutamol/min., and can be increased to 10 mcg/min., and 20 mcg/min. at 15 - 30 minute intervals, if necessary.
• As with all parenteral drug products, intravenous admixtures should be inspected visually for clarity, particulate matter, precipitate, discoloration and leakage prior to administration.
• All unused admixtures of Salbutamol infusion solution with infusion fluids should be discarded 24 hours after preparation.

• Adults: For the relief of bronchospasm and for managing intermittent episodes of asthma, one or two inhalation capsule may be administered as a single dose. The usual recommended dosage of Salbutamol inhalation capsule for inhalation for adults for maintenance or prophylactic therapy is the contents of one 200 microgram capsule every 4 to 6 hours using a device. In some patients, the contents of two 200 microgram capsules inhaled every 4 to 6 hours may be required. Large doses or more frequent administration is not recommended. The use of salbutamol powder for inhalation can be continued as medically indicated to control recurring/intermittent episodes of bronchospasm.
• Children: One Salbutamol inhalation capsule is the recommended dose for relief of acute bronchospasm in the maintenance of episodic asthma or before exercise of children 4 years of age and older. One inhalation should be administered for three or four times a day for routine maintenance or prophylactic therapy. This dosage may be increased to inhalation of two inhalation capsule, if necessary. The bronchodilator effect of each administration of inhaled Salbutamol inhalation capsule lasts for at least four hours. Such patients should be warned not to increase the dose of inhaler, but should seek medical advice immediately.

• Adults: 400 microgram
• Child: 200 microgram, 15-30 minutes prior to any physical exertion.

Asthmolin Syrup 2 mg/5 ml is recommended and available in different strengths ranging from 2mg to 8mg. The dosage should be determined based on age, weight, and other factors as recommended by the doctor. The dosage is usually taken 2 to 4 times a day. Inhaled salbutamol is usually prescribed along with other medications known as 'controller medicines' such as corticosteroids, that are used to reduce the frequency and intensity of asthma attacks.

Administration

Inhaled salbutamol medications are usually taken orally or by inhalation using an inhaler or a nebulizer machine, depending on the patient's condition and severity of the disease. The inhaler or the nebulizer machine must be used properly to ensure that the medicine is delivered directly to the lungs.

Side Effects

Common side effects of salbutamol include tremor (shaking), headache, dry mouth, throat irritation, nausea, increased heart rate, palpitations, and dizziness.

Toxicity

Overdoses of Asthmolin Syrup 2 mg/5 ml can lead to high blood potassium levels and heart rhythm disturbances. High doses or prolonged use can also cause serious side effects such as seizures or muscle weakness.

Precaution

Patients should always inform the physician about any health problems they have, such as heart disease, high blood pressure or diabetes, in order to avoid the risk of adverse drug reactions. Also, salbutamol should be used with caution in pregnant women or those who are breastfeeding.

Interactions

Asthmolin Syrup 2 mg/5 ml is known to interact with certain other medications such as diuretics, MAO inhibitors, beta blockers, ACE inhibitors, calcium channel blockers, and some antibiotics. So, it is important to inform your doctor about all your medications before using salbutamol.

Disease Interaction

Asthmolin Syrup 2 mg/5 ml is known to interact with certain diseases such as diabetes, hyperthyroidism, heart disease, renal and hepatic impairment, and mucoid impaction.

Drug Interaction

Asthmolin Syrup 2 mg/5 ml is known to interact with certain drugs such as diuretics, MAO inhibitors, beta blockers, ACE inhibitors, calcium channel blockers, and some antibiotics.

Food Interactions

There are no known significant food interactions with Asthmolin Syrup 2 mg/5 ml. However, it is recommended to limit or avoid caffeine while taking Asthmolin Syrup 2 mg/5 ml medications.

Pregnancy Use

Asthmolin Syrup 2 mg/5 ml is not recommended for use in pregnant women. It is recommended to avoid using Asthmolin Syrup 2 mg/5 ml during pregnancy, as it may cause serious harm to an unborn baby.

Lactation Use

It is generally recommended to avoid using Asthmolin Syrup 2 mg/5 ml in breastfeeding mothers, as it is not known if it can pass into breast milk. It is advisable to consult a physician before using Asthmolin Syrup 2 mg/5 ml in breastfeeding mothers.

Acute Overdose

The signs and symptoms of an acute overdose of Asthmolin Syrup 2 mg/5 ml include chest pain, tremors, rapid heartbeat, headache, nausea, vomiting, dizziness, and seizures. If any of these symptoms occur after taking Asthmolin Syrup 2 mg/5 ml, contact a healthcare professional immediately.

Contraindication

Asthmolin Syrup 2 mg/5 ml is contraindicated in people with hypersensitivity or allergy to its active ingredients, hypersensitivity to sympathomimetic amines, tachyarrhythmia, and coronary insufficiency.

Use Direction

The dosage and use of salbutamol should always be determined after consulting a doctor or a healthcare professional. Proper instructions should be followed while using an inhaler or nebulizer device.

Storage Condition

Asthmolin Syrup 2 mg/5 ml inhalers or nebulizer solutions should be stored at room temperature, away from direct heat and light.

Volume of Distribution

The volume of distribution of salbutamol depends on the route of administration. After intravenous administration, the volume of distribution is 1L/kg.

Half Life

The half-life of salbutamol is approximately 4-6 hours after administration.

Clearance

The clearance of salbutamol after oral administration is approximately 120 mL/min/kg.

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Some Frequently Asked Questions About Asthmolin Syrup 2 mg/5 ml

1. What is Asthmolin Syrup 2 mg/5 ml?

Asthmolin Syrup 2 mg/5 ml (also known as Albuterol in some countries) is a bronchodilator that helps relax the muscles in the airways, making breathing easier.

2. What is Asthmolin Syrup 2 mg/5 ml used for?

It is used to treat and prevent conditions like:

• Asthma
• Chronic Obstructive Pulmonary Disease (COPD)
• Exercise-induced bronchospasm

3. How does Asthmolin Syrup 2 mg/5 ml work?

It acts on **beta-2 adrenergic receptors** in the lungs, relaxing airway muscles and improving airflow.

4. Is Asthmolin Syrup 2 mg/5 ml a steroid?

No, Asthmolin Syrup 2 mg/5 ml is a **bronchodilator**, not a steroid.

5. How should I use Asthmolin Syrup 2 mg/5 ml inhalers?

Shake the inhaler well and inhale **one or two puffs** as prescribed. Wait at least **30-60 seconds** between puffs.

6. Can Asthmolin Syrup 2 mg/5 ml be used as a long-term treatment?

No, it is mainly a **rescue medication** for sudden breathing difficulties. Long-term control requires other medications like corticosteroids.

7. What are the side effects of Asthmolin Syrup 2 mg/5 ml?

Common side effects include:

• Tremors or shakiness
• Increased heart rate
• Headache
• Nervousness
• Muscle cramps

8. Can I use Asthmolin Syrup 2 mg/5 ml daily?

It should only be used **as needed**. Frequent use may indicate poor asthma control, requiring medical review.

9. Can children use Asthmolin Syrup 2 mg/5 ml?

Yes, but the dosage and frequency should be determined by a doctor.

10. How long does it take for Asthmolin Syrup 2 mg/5 ml to work?

It starts working within **5-15 minutes** and lasts for about **4-6 hours**.

11. Is Asthmolin Syrup 2 mg/5 ml available in tablet form?

Yes, Asthmolin Syrup 2 mg/5 ml is available as **tablets, syrup, inhalers, and nebulizer solutions**.

12. Can I overdose on Asthmolin Syrup 2 mg/5 ml?

Yes. Overdose symptoms include severe tremors, chest pain, fast heart rate, and seizures. Seek immediate medical help.

13. Can Asthmolin Syrup 2 mg/5 ml be used during pregnancy?

It can be used if the benefits outweigh the risks, but it should be taken only under medical supervision.

14. Can Asthmolin Syrup 2 mg/5 ml be used for cough?

It is not a cough suppressant, but it may help if the cough is due to **bronchospasm or asthma**.

15. Can I take Asthmolin Syrup 2 mg/5 ml with other asthma medications?

Yes, it is often used with inhaled corticosteroids or long-acting bronchodilators.

16. Can I drink alcohol while using Asthmolin Syrup 2 mg/5 ml?

Alcohol may increase side effects like dizziness, so it's best to limit consumption.

17. How often can I use Asthmolin Syrup 2 mg/5 ml?

Use **as prescribed**, usually **every 4-6 hours** as needed. Frequent use may indicate worsening asthma.

18. Can I use Asthmolin Syrup 2 mg/5 ml before exercise?

Yes, it is often used **15-30 minutes before exercise** to prevent exercise-induced bronchospasm.

19. Can Asthmolin Syrup 2 mg/5 ml cause weight gain?

No, it does not cause weight gain.

20. Can Asthmolin Syrup 2 mg/5 ml cause anxiety?

Yes, it may cause nervousness or anxiety in some people.

21. Does Asthmolin Syrup 2 mg/5 ml affect blood pressure?

It may cause a slight increase in blood pressure in some individuals.

22. Can Asthmolin Syrup 2 mg/5 ml cause drowsiness?

No, it usually does not cause drowsiness.

23. Is Asthmolin Syrup 2 mg/5 ml safe for people with heart disease?

Use with caution, as it may increase heart rate. Consult a doctor if you have heart disease.

24. Can Asthmolin Syrup 2 mg/5 ml cause dizziness?

Yes, dizziness is a possible side effect.

25. How should I store Asthmolin Syrup 2 mg/5 ml?

Store it at **room temperature**, away from heat and moisture.

26. Can I use Asthmolin Syrup 2 mg/5 ml with a nebulizer?

Yes, a **nebulizer solution** form is available for severe cases.

27. Does Asthmolin Syrup 2 mg/5 ml interact with other medications?

Yes, it may interact with **beta-blockers, diuretics, and some antidepressants**.

28. Can Asthmolin Syrup 2 mg/5 ml cause headaches?

Yes, headache is a common side effect.

29. Can Asthmolin Syrup 2 mg/5 ml cause palpitations?

Yes, it can cause heart palpitations in some people.

30. Is Asthmolin Syrup 2 mg/5 ml addictive?

No, it is not addictive.

31. Can I take Asthmolin Syrup 2 mg/5 ml if I have diabetes?

Yes, but it may increase blood sugar levels. Monitor blood sugar closely.

32. Can I take Asthmolin Syrup 2 mg/5 ml on an empty stomach?

Yes, it can be taken with or without food.

33. What happens if I miss a dose?

Take it as soon as you remember, but do not double the dose.

34. Can Asthmolin Syrup 2 mg/5 ml cause muscle cramps?

Yes, muscle cramps are a possible side effect.

35. Can Asthmolin Syrup 2 mg/5 ml cause a sore throat?

Yes, some users experience throat irritation.

36. Can Asthmolin Syrup 2 mg/5 ml cause stomach pain?

Yes, stomach discomfort may occur in some people.

37. Is Asthmolin Syrup 2 mg/5 ml used for bronchitis?

It may help if bronchitis causes airway constriction.

38. Can I use Asthmolin Syrup 2 mg/5 ml during an asthma attack?

Yes, it is commonly used as a **rescue inhaler** during asthma attacks.

39. Can Asthmolin Syrup 2 mg/5 ml be used for pneumonia?

It does not treat pneumonia but may help ease breathing difficulties.

40. Can I use Asthmolin Syrup 2 mg/5 ml with antihistamines?

Yes, but consult your doctor for potential interactions.

41. Can Asthmolin Syrup 2 mg/5 ml affect sleep?

Yes, it may cause insomnia in some people.

42. Can I use Asthmolin Syrup 2 mg/5 ml if I have high blood pressure?

Yes, but it should be monitored by a doctor.

43. Can I smoke while using Asthmolin Syrup 2 mg/5 ml?

No, smoking worsens lung conditions and reduces medication effectiveness.

44. Can Asthmolin Syrup 2 mg/5 ml be used for allergies?

It does not treat allergies but may help if allergies cause breathing issues.

45. Can Asthmolin Syrup 2 mg/5 ml cause chest pain?

Rarely, but seek medical help if chest pain occurs.

46. Can Asthmolin Syrup 2 mg/5 ml cause shaking?

Yes, mild tremors are common.

47. Can I use expired Asthmolin Syrup 2 mg/5 ml?

No, expired medication may not be effective.

48. Can Asthmolin Syrup 2 mg/5 ml cause a rash?

Yes, allergic reactions can cause a rash.

49. Can I take Asthmolin Syrup 2 mg/5 ml before sleep?

It may cause insomnia, so use it earlier if possible.