Aspirin

Introduction

Aspirin (acetylsalicylic acid) belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). It has been used for thousands of years to relieve pain and reduce inflammation. It is also used to reduce the risk of heart attacks and strokes in certain patients, reduce the risk of certain types of cancers, and is used to treat fever. Aspirin is available as an over-the-counter product, in a variety of formulation and doses.

Uses

Aspirin is used to relieve pain and reduce inflammation, reduce the risk of heart attacks and strokes in certain patients, reduce the risk of certain types of cancers, and is used to treat fever. In addition, it may be taken to reduce the risk of blood clots, which can cause a heart attack or stroke. Aspirin may also be used to treat other medical conditions as determined by your doctor.

Brand Name	Aspirin
Type
Weight
Generic	Aspirin
Manufacturer
Available in	English বাংলা

Mechanism of Action

Aspirin works by blocking the production of certain hormones called prostaglandins, which are responsible for inflammation, pain, and fever. Aspirin also works by preventing blood clotting and reducing the risk of heart attacks and strokes.

How Long Does It Take To Work?

Aspirin works quickly to relieve pain, reduce inflammation and fever. Depending on the dose and formulation, the effects can be felt in as little as 15 minutes or up to an hour.

Absorption

Aspirin is rapidly absorbed in the gastrointestinal tract. It is for this reason that aspirin is recommended for use immediately after a suspected heart attack or stroke.

Route of Elimination

Aspirin is rapidly eliminated from the body by the kidneys. Approximately half of the aspirin is removed within 4 hours, and virtually all of the aspirin is eliminated within 24 hours.

Dosage

Pain, inflammatory diseases and as antipyretic: Aspirin 300 mg 1-3 tablets 6 hourly with a maximum daily dose of 4 gm.

Suspected acute coronary syndrome: 150 mg-300 mg immediately unless there are clear contraindications.

After myocardial infarction: Aspirin 150 mg daily for 1 month. Long-term use of aspirin in a dose of 75 mg daily is recommended thereafter.

Acute ischaemic stroke/Transient ischaemic stroke (TIA): The starting dose is 150 mg-300 mg daily and Aspirin 75 mg daily thereafter.

Following bypass surgery: 75 mg-300 mg daily starting 6 hours post-procedure.

The recommended dose of aspirin varies based on age, weight, medical condition, and indication for use. Generally speaking, adults should take 325mg to 650mg every four to six hours for mild to moderate pain relief. Aspirin should only be used for-mustaches under the guidance of a healthcare practitioner.

Administration

Aspirin is taken orally. It may be taken with or without food. Aspirin should not be taken with alcohol.

Side Effect

The most common side effects of aspirin include stomach upset, nausea, heartburn, and rash. Other serious side effects include gastrointestinal bleeding, kidney damage, and an increased risk of bleeding in the brain.

Toxicity

Aspirin is generally safe when taken as directed. However, overdose or prolonged use can lead to serious side effects such as liver damage, internal bleeding, and kidney failure.

Precautions

Before taking aspirin, tell your healthcare provider about any medications or supplements you are taking and any allergies you have. In addition, tell your healthcare provider if you have a history of bleeding or are taking anticoagulants, as aspirin may increase the risk of bleeding. Aspirin should not be given to children under the age of 16 as it can cause a dangerous condition called Reye’s Syndrome.

Interactions

Aspirin may interact with other medications including blood thinners, NSAIDs, certain antibiotics, certain antidepressants, certain cancer treatments, and more. Therefore, it is important to tell your healthcare provider about all medications and supplements you are taking.

Disease Interactions

Aspirin may interact with certain medical conditions, including allergy to aspirin, asthma, bleeding or clotting disorders, high blood pressure, diabetes, heart disease, stroke, stomach ulcers, and kidney or liver disease. It is important to tell your healthcare provider about any medical conditions you have before taking aspirin.

Drug Interactions

Aspirin may interact with certain medications including blood thinners, NSAIDs, certain antibiotics, certain antidepressants, certain cancer treatments, and more. Therefore, it is important to tell your healthcare provider about all medications and supplements you are taking.

Food Interactions

Aspirin may interact with certain foods such as alcohol, grapefruit, and certain foods high in vitamin K such as kale and spinach. Therefore, you should avoid drinking alcohol while taking aspirin, and you should talk to your healthcare provider before eating foods high in vitamin K.

Pregnancy Use

Aspirin is generally not recommended during pregnancy, as it can increase the risk of certain birth defects. However, your healthcare provider may recommend taking low-dose aspirin to reduce the risk of pre-eclampsia if you are at a high risk for the condition. Talk to your healthcare provider about using aspirin while pregnant.

Lactation Use

Aspirin is generally considered safe to take while breastfeeding. However, it is important to talk to your healthcare provider before taking any medication while breastfeeding.

Acute Overdose

Signs of an aspirin overdose may include nausea, vomiting, stomach pain, dizziness, drowsiness, and confusion. An overdose of aspirin can be dangerous and should be treated by a healthcare professional. If you or someone you know has taken an overdose of aspirin, seek medical help immediately.

Contraindications

Aspirin should not be taken by people with certain conditions or allergies, such as: asthma, a history of stomach ulcers, an allergy to aspirin or other NSAIDs, bleeding or clotting disorders, or kidney or liver diseases. It should also not be taken by women during the third trimester of pregnancy.

Use Direction

Aspirin should always be taken as directed by your healthcare provider. Aspirin should not be taken for more than 10 days in a row unless directed by your healthcare provider. Aspirin should not be taken in combination with other medications unless advised by your healthcare provider.

Storage Condition

Aspirin should be stored at room temperature in a tightly sealed container away from heat, light, and moisture. It should be kept out of the reach of children and pets.

Volume of Distribution

The volume of distribution of aspirin, also known as the volume of body distribution, is approximately 0.4 L/kg. This means that the drug is distributed evenly throughout the body.

Half Life

The half-life of aspirin is approximately 15 minutes. This means that the drug is cleared from the body in approximately four hours.

Clearance

The clearance of aspirin from the body is approximately 0.05-0.2 ml/min/kg. This means that the drug is cleared from the body relatively quickly.

See in details version Aspirin also Aspirin in bangla

Some Frequently Asked Questions About Aspirin