About Artem
Artem Syrup
(Aexim Pharmaceuticals Ltd.)
is a brand medicine
containing the generic
Artemether + Lumefantrine
.
Current listed price in Bangladesh: 60 ml bottle: ৳ 220.00.
Medical information for Artem Syrup (15 mg+90 mg)/5 ml
Uses, dosage, side effects, and safety details below apply to
Artem Syrup (15 mg+90 mg)/5 ml
(generic:
Artemether + Lumefantrine).
This is general information — consult a doctor before use.
What is Artem Syrup (15 mg+90 mg)/5 ml?
Artem Syrup (15 mg+90 mg)/5 ml (also known as Coartem or artemether + lumefantrine combination) is a combination medication used to treat malaria. It is a fixed-dose combination of two drugs, artemether (an antimalarial drug) and lumefantrine (a lipophilic allylamine).
Uses For Artem Syrup (15 mg+90 mg)/5 ml
Artem Syrup (15 mg+90 mg)/5 ml is used to help treat infected individuals with malaria and to reduce the spread of malaria in areas with a high infection rate. It may also be used to help treat recurrent acute attacks of malaria and lessen the severity of symptoms.
Mechanism of Action
Artem Syrup (15 mg+90 mg)/5 ml works by interfering with the DNA of the Plasmodium parasite and blocking its growth. Artemether affects the building of the parasite's cell membrane and lumefantrine stops the spread of the parasites.
How Long Does it Take to Work?
Artem Syrup (15 mg+90 mg)/5 ml starts to take effect within 2 days. However, it may take up to 2 weeks to clear the infection and up to 4 weeks for full recovery.
Absorption
Artem Syrup (15 mg+90 mg)/5 ml is rapidly and almost completely absorbed from the gastrointestinal tract.
Route of Elimination
Artem Syrup (15 mg+90 mg)/5 ml is primarily eliminated by the kidneys, although it may also be eliminated through bile or feces.
Dosage
Patients with acute malaria are frequently averse to food. The dose should be taken with high fat food or drinks such as milk. In the event of vomiting within 1 hour of administration a repeat dose should be taken.
Adults and children weighing 35 kg and above: A standard 3 days treatment schedule with a total of 6 doses is recommended dosage is 4 tablets as a single dose at the time of initial diagnosis, again 4 tablets after eight hours, and then 4 tablets twice daily (morning and evening) on each of the following two days (Total course comprises 24 tablets).
5 to <15 kg body weight: 1 tablet at the time of initial diagnosis, 1 tablet again after 8 hours and then 1 tablet twice daily (morning and evening) on each of the following two days (Total course comprises of 6 tablets).
15 to <25 kg body weight: 2 tablets as a single dose at the time of initial diagnosis , 2 tablets again after 8 hours and then 2 tablets twice daily (morning and evening) on each of the following two days (Total course comprises 12 tablets).
25 to <35 kg body weight: 3 tablets as a single dose at the time of initial diagnosis, 3 tablets again after 8 hours and then 3 tablets twice daily (morning and evening) on each of the following two days (Total courses comprises 18 tablets).
The recommended dose for Artem Syrup (15 mg+90 mg)/5 ml is 4 tablets twice daily, with food, for 3 days.
Administration
Artem Syrup (15 mg+90 mg)/5 ml should be taken with food for maximum effectiveness.
Side Effects
The most common side effects of Artem Syrup (15 mg+90 mg)/5 ml include nausea, abdominal pain, vomiting, and diarrhea. Other side effects may include anorexia, dizziness, headache, drowsiness, rash, pruritus, and insomnia.
Toxicity
The toxicity of Artem Syrup (15 mg+90 mg)/5 ml is low. There have been reports of adverse events related to taking the combination medication, such as nausea, vomiting, and abdominal discomfort.
Precaution
Patients should inform their healthcare provider of any history of liver or kidney diseases, allergies, or other medical conditions before taking Artem Syrup (15 mg+90 mg)/5 ml.
Interaction
Artem Syrup (15 mg+90 mg)/5 ml may interact with other medications, including antacids, barbiturates, anticoagulants, penicillins, and phenytoin.
Disease Interaction
Artem Syrup (15 mg+90 mg)/5 ml is not recommended for use in patients with severe renal impairment.
Drug Interaction
Artem Syrup (15 mg+90 mg)/5 ml may interact with certain drugs, including cimetidine, ranitidine, phenobarbital, and rifabutin.
Food Interactions
Food may decrease the absorption of Artem Syrup (15 mg+90 mg)/5 ml. It is best taken with food.
Pregnancy Use
Artem Syrup (15 mg+90 mg)/5 ml may be used during pregnancy.
Lactation Use
Artem Syrup (15 mg+90 mg)/5 ml is not recommended for use in breastfeeding women.
Acute Overdose
If an overdose occurs, it is important to seek medical attention immediately. Symptoms of an acute overdose may include nausea, vomiting, and abdominal pain.
Contraindication
Artem Syrup (15 mg+90 mg)/5 ml is contraindicated in patients with a known hypersensitivity to any components of the medication.
Use Direction
Artem Syrup (15 mg+90 mg)/5 ml should be taken as prescribed by a healthcare provider.
Storage Conditions
Artem Syrup (15 mg+90 mg)/5 ml should be stored at room temperature in a cool, dry place.
Volume of Distribution
The volume of distribution of Artem Syrup (15 mg+90 mg)/5 ml is estimated to be 0.91 L.
Half-Life
The estimated half-life of Artem Syrup (15 mg+90 mg)/5 ml is 11 - 14 hours.
Clearance
The estimated clearance of Artem Syrup (15 mg+90 mg)/5 ml is 0.28 L/hr.
Full generic monograph:
Artemether + Lumefantrine — uses, dosage & side effects
Medical review
Last reviewed:
30 Aug 2024
Medically reviewed by:
This is general information, not personal medical advice. Consult a doctor before taking any medicine.
Taking medicines without doctor's advice can cause long-term problems.
