Arovan Capsule

Introduction

Arovan Capsule 80 mg is a medication used to treat high blood pressure (hypertension) and congestive heart failure. It is a type of angiotensin II receptor blocker (ARB) that works by blocking a specific type of angiotensin receptor, thereby blocking the effect of angiotensin II and reducing blood pressure.

Uses

Arovan Capsule 80 mg is used to treat hypertension (high blood pressure), to reduce the risk of stroke, and to improve survival after a heart attack or congestive heart failure. It can also be given to reduce the risk of death after a heart attack.

Brand Name	Arovan
Type	Capsule
Weight	80 mg
Generic	Valsartan
Manufacturer	Aristopharma Ltd.
Available in	English বাংলা

Mechanism of Action

Arovan Capsule 80 mg works by blocking a type of angiotensin receptor. Angiotensin is a natural hormone that narrows and constricts blood vessels, increasing blood pressure. By blocking this angiotensin receptor, valsartan reduces blood pressure by relaxing blood vessels and reducing the workload of the heart.

How Long Does It Take to Work?

Arovan Capsule 80 mg’s effects begin to occur within 1-2 hours after ingestion and reach maximal effect within 2-6 hours. The drug’s effects on blood pressure and heart rate can be seen for 24 hours after ingestion.

Absorption

Arovan Capsule 80 mg is rapidly absorbed from the gastrointestinal tract. Its absorption is unaffected by food intake. On average, it takes 4-5 hours for the drug to reach peak plasma concentrations.

Route of Elimination

Arovan Capsule 80 mg is eliminated mainly through the kidneys and intestinal tract. It is metabolized in the liver and excreted through urine and feces.

Dosage

Hypertension: The usual dose of Valsartan is 80 to 160 mg once daily. The maximum dose is 320 mg daily. Maximum blood pressure reduction occurs within 4 weeks.

Heart failure: The usual dose is 40 mg twice daily and may be increased to 80-160 mg twice daily.

Post-Myocardial Infarction: The initial dose after myocardial infarction is 20 mg twice daily. The dose should be increased with a target of 160 mg daily if tolerated without side effects.

Arovan Capsule 80 mg comes in oral tablet form in strengths ranging from 10 mg to 160 mg. The recommended starting dose for adults is 80-160 mg once a day. The dosage may be increased by 80 mg every two weeks until the desired response is achieved. For people with severe hypertension, the maximum dose is 320 mg per day.

Administration

Arovan Capsule 80 mg is taken orally once a day. It can be taken with or without food.

Side Effect

Common side effects of valsartan include dizziness, headache, fatigue, nausea, and diarrhea. Less common side effects may include a rash, abdominal pain, and joint pain.

Toxicity

Arovan Capsule 80 mg is generally well-tolerated, with mild side effects in most people. Overdose may cause hypotension and tachycardia. It can also cause organ system dysfunction due to its long half life and large volume of distribution.

Precautions

People with liver or kidney disease and those with severe dehydration should not take valsartan. Also, people with reduced kidney function, anuria, or hypersensitivity to ARBs should not take valsartan. Additionally, pregnant or breast-feeding women should not take valsartan.

Interactions

Arovan Capsule 80 mg may interact with other medications, such as diuretics, ACE-inhibitors, NSAIDs, and some antibiotics. It is important to tell your doctor about any other medications you are taking before starting valsartan.

Disease Interaction

Arovan Capsule 80 mg may worsen heart failure in some people. It can also worsen renal function in some people with pre-existing kidney disease. Additionally, valsartan may worsen the symptoms of diabetes and increase the risk of developing hyperkalemia (high potassium levels in the blood).

Drug Interaction

Food Interactions

Arovan Capsule 80 mg may interact with food, but this interaction is usually not clinically significant. It may be taken with or without food.

Pregnancy Use

Arovan Capsule 80 mg should not be used during pregnancy unless absolutely necessary. If it is used, the dose should be adjusted according to the individual's body weight, kidney and liver function. It is important to talk to your doctor about the potential risks and benefits before starting valsartan during pregnancy.

Lactation Use

The safety of valsartan during lactation is not known. It is best to avoid valsartan while breastfeeding unless the benefits clearly outweigh the risks.

Acute Overdose

An overdose of valsartan can cause serious side effects, including extreme low blood pressure, fainting, and a drop in heart rate. In cases of acute overdose, call emergency medical services immediately.

Contraindication

Arovan Capsule 80 mg should not be used in pregnant women, people with reduced kidney function, anuria, hypersensitivity to ARBs, patients with severe dehydration, or by people with liver or kidney disease.

Use Directions

Arovan Capsule 80 mg should be taken once a day as prescribed by your doctor. It can be taken with or without food. Do not change the dose or suddenly stop taking valsartan without consulting your doctor.

Storage Condition

Store valsartan at room temperature, away from heat and light. Keep it away from children and pets. Discard any unused medication.

Volume of Distribution

Arovan Capsule 80 mg has a large volume of distribution, which means it is widely distributed in the body. It also has a long half-life and a long elimination half-life, which means that it stays in the body longer than most other drugs.

Half Life

The half-life of valsartan is 6-9 hours. This means that half of the amount of the drug taken is eliminated from the body in 6-9 hours.

Clearance

Arovan Capsule 80 mg is cleared from the body mainly through the kidneys and intestinal tract. Its clearance is decreased in people with kidney impairment, so the dose needs to be adjusted accordingly.

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