Introduction
Pseudoephedrine, Guaiphenasine and Triprolidine are three medications that are commonly used together to treat symptoms of the common cold, allergies, and other sinus and nasal congestion. This combination is most commonly available as a fixed combination oral tablets.Uses
Commonly, this multi-ingredient medication is used to provide relief of a variety of upper respiratory symptoms associated with the common cold, allergies, sinus and nasal congestion. These symptoms include sneezing, nasal discharge, and congestion, as well as mild-to-moderate pain.| Brand Name | Aquaphen |
|---|---|
| Type | Syrup |
| Weight | (30 mg+100 mg+1.25 mg)/5 ml |
| Generic | Pseudoephedrine + Guaiphenasine + Triprolidine |
| Manufacturer | Incepta Pharmaceuticals Ltd. |
| Available in | English বাংলা |
Mechanism of Action
This combination of medications works by reducing inflammation of the nasal passages, thereby relieving nasal congestion and sneezing. Additionally, Pseudoephedrine acts as a vasoconstrictor to help relieve sinus pressure, while Guaiphenasine and Triprolidine act as antihistamines to help reduce sneezing and clear nasal passages.How Long Does It Take To Work?
The effect of this combination medication usually begins within 30 minutes of administration, and it can last up to 12 hours.Absorption
The three ingredients in this combination medication are quickly absorbed into the bloodstream after oral administration.Route of Elimination
Once absorbed, this combination medication is metabolized by the liver and eliminated primarily through the kidneys.Dosage
Adult and Children over 12 years: 10 ml (2 teaspoonful) three times a day.Children 6-12 years: 5 ml (1 teaspoonful) three times a day.
Children 2-5 years: 2.5 ml (1/2 teaspoonful) three times a day.
A physician’s advice is preferred before administering this preparation to children aged less than 2 years. The recommended dose of this combination medication is 1 to 2 tablets every 4 to 6 hours as needed. Each tablet contains 30 mg of Pseudoephedrine, 5 mg of Guaiphenasine, and 1.25 mg of Triprolidine.
Administration
This medication is taken orally. It can be taken with or without food.Side Effects
The most common side effects associated with this medication include drowsiness, dry mouth, headache, dizziness, stomach upset, and difficulty urinating.Toxicity
High doses of this medication can lead to toxicity, which may include restlessness, tremor, palpitations, muscle cramps, and seizures.Precautions
This medication should be used with caution in patients with glaucoma, increased intraocular pressure, hyperthyroidism, heart disease, liver or kidney disease, or urinary tract disease, as well as in the elderly and in women who are pregnant or breastfeeding.Interaction
This medication may interact with other medications, including antidepressants, antacids, antihistamines, decongestants, diuretics, and monoamine oxidase inhibitors (MAOIs).Disease Interaction
This medication may worsen the symptoms of hyperthyroidism, heart disease, and urinary tract disease, and can cause increased intraocular pressure in patients with glaucoma.Drug Interaction
This medication may interact with other medications, including antidepressants, antacids, antihistamines, decongestants, diuretics, and monoamine oxidase inhibitors (MAOIs).Food Interactions
Pseudoephedrine, Guaiphenasine, and Triprolidine have no known food interactions.Pregnancy Use
This medication should be used with caution by pregnant women, as it is not recommended for use in pregnant women.Lactation Use
This medication should be used with caution by breastfeeding women, as it is not recommended for use in breastfeeding women.Acute Overdose
An acute overdose of this medication can be dangerous. Symptoms of an acute overdose may include restlessness, tremor, palpitations, muscle cramps, and seizures. If an overdose is suspected, seek medical attention immediately.Contraindication
This medication is contraindicated in patients with known hypersensitivity to any of the ingredients in the product, and in patients taking monoamine oxidase inhibitors (MAOIs).Use Direction
This medication should be taken exactly as directed by a health care provider. Do not take more or less than the recommended dose.Storage Condition
This medication should be stored at room temperature away from light and moisture.Volume of Distribution
The volume of distribution for this medication is not known.Half Life
The half-life for Pseudoephedrine is 6-12 hours, for Guaiphenasine is 5 hours, and for Triprolidine is 4-5 hours.Clearance
The clearance for Pseudoephedrine is not known, for Guaiphenasine is 0.6-2.6 L/min, and for Triprolidine is 0.3-1.2 L/min.See in details version Aquaphen Syrup (30 mg+100 mg+1.25 mg)/5 ml also Aquaphen Syrup (30 mg+100 mg+1.25 mg)/5 ml in bangla
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Some Frequently Asked Questions About Aquaphen Syrup (30 mg+100 mg+1.25 mg)/5 ml
1. What is Pseudoephedrine + Guaiphenesin + Triprolidine?
It is a combination medication used to treat symptoms of cold, cough, nasal congestion, and allergies.
2. What are the active ingredients and their functions?
- Pseudoephedrine: A decongestant that shrinks swollen nasal passages.
- Guaiphenesin: An expectorant that loosens mucus in the airways.
- Triprolidine: An antihistamine that relieves sneezing, runny nose, and itchy eyes.
3. What is this medication used for?
It is used to relieve symptoms of colds, flu, sinus congestion, allergies, and bronchial irritation.
4. How should I take this medication?
Take it as directed by your doctor, usually every 4-6 hours with water.
5. Can I take this medication on an empty stomach?
Yes, but taking it with food may reduce stomach discomfort.
6. What should I do if I miss a dose?
Take it as soon as you remember. If it's close to your next dose, skip the missed dose.
7. Can I crush or chew this medication?
No, swallow the tablet whole with water.
8. What are the common side effects?
- Dizziness
- Dry mouth
- Increased heart rate
- Nausea
- Restlessness
- Drowsiness
9. Can this medication cause drowsiness?
Yes, Triprolidine is an antihistamine that may cause drowsiness.
10. Can I drive or operate machinery while taking this medication?
Avoid driving if you feel drowsy or dizzy after taking this medication.
11. Can I drink alcohol while taking this medication?
No, alcohol can increase drowsiness and dizziness.
12. Can I take this medication if I have high blood pressure?
Consult your doctor first, as Pseudoephedrine can raise blood pressure.
13. Can pregnant women take this medication?
It should only be used if prescribed by a doctor during pregnancy.
14. Can breastfeeding mothers take this medication?
No, it may pass into breast milk and affect the baby.
15. Is this medication suitable for children?
It is usually not recommended for children under 6 years without a doctor's advice.
16. Can elderly patients take this medication?
Yes, but with caution as they may be more sensitive to side effects like dizziness and dry mouth.
17. Can I take this medication with other cold or flu medicines?
No, combining multiple cold medications may lead to an overdose.
18. Does this medication interact with other drugs?
- Antidepressants (e.g., MAO inhibitors)
- Beta-blockers
- Blood pressure medications
- Other decongestants or antihistamines
19. Can this medication cause trouble sleeping?
Yes, Pseudoephedrine can cause restlessness or insomnia.
20. Can I take this medication if I have asthma?
Consult your doctor, as it may worsen asthma symptoms in some cases.
21. Can this medication cause dry mouth?
Yes, Triprolidine may cause dry mouth as a side effect.
22. Can I take this medication with antibiotics?
Yes, but consult your doctor to ensure there are no interactions.
23. Does this medication affect blood sugar levels?
Pseudoephedrine may slightly increase blood sugar, so diabetics should monitor their levels.
24. Can this medication cause heart palpitations?
Yes, Pseudoephedrine can cause an increased heart rate in some individuals.
25. Can I take this medication with a cough syrup?
Only if it does not contain additional decongestants or antihistamines.
26. How long does it take for this medication to work?
It usually starts working within 30 minutes to 1 hour.
27. How long should I take this medication?
Do not use for more than 7 days unless prescribed by a doctor.
28. Can I stop taking this medication suddenly?
Yes, but stopping suddenly may cause congestion to return.
29. Can I take this medication with ibuprofen?
Yes, there are no known interactions.
30. Can this medication cause allergic reactions?
Rarely, but seek medical help if you experience swelling, itching, or difficulty breathing.
31. Can I take this medication if I have liver disease?
Consult your doctor first.
32. Can I take this medication if I have kidney disease?
Yes, but dose adjustments may be needed.
33. Does this medication contain caffeine?
No, but Pseudoephedrine can have a stimulating effect.
34. Can this medication cause nausea?
Yes, nausea is a possible side effect.
35. Can I take this medication with herbal supplements?
Consult your doctor before combining it with herbal medicines.
36. Can I take this medication before bedtime?
It may cause difficulty sleeping due to Pseudoephedrine.
37. Does this medication cause constipation?
No, it is not a common side effect.
38. Can I take this medication if I have thyroid disease?
Consult your doctor, as Pseudoephedrine can affect thyroid hormones.
39. Can this medication cause vision problems?
Rarely, but some people may experience blurred vision.
40. Can I take this medication during flu season?
Yes, it helps relieve symptoms of flu.
41. Can this medication be habit-forming?
No, but long-term use is not recommended.
42. Can I take this medication if I have anemia?
Yes, but consult your doctor first.
43. Does this medication cause skin rashes?
Rarely, but discontinue use if you develop a rash.
44. Can I take this medication with vitamin C?
Yes, there are no known interactions.
45. How should I store this medication?
Store in a cool, dry place away from direct sunlight.
46. Can I take this medication with antihistamines?
No, as Triprolidine is already an antihistamine.
47. Can this medication be used for allergies?
Yes, it helps relieve allergy symptoms like sneezing and runny nose.
48. Can I take this medication on a long flight?
Yes, it can help relieve nasal congestion during air travel.
49. Does this medication contain steroids?
No, it does not contain steroids.
50. Can I take this medication with an antacid?
Yes, there are no significant interactions.
