Anodyne Plus IM Injection

Introduction

Diclofenac Sodium and Lidocaine Hydrochloride are prescription medications used to treat several medical conditions. They are a combination of two drugs with different mechanisms of action, acting on different receptors in the body. Diclofenac Sodium is a non-steroidal anti-inflammatory drug (NSAID) used to reduce inflammation and pain. Lidocaine hydrochloride is an anesthetic and antiarrhythmic agent used to reduce the sensitivity of nerve endings, relieve pain, and to treat irregular heartbeats.

Uses For

Diclofenac Sodium and Lidocaine Hydrochloride is primarily used to relieve pain and inflammation, and to treat irregular heartbeats. It is indicated for use in the treatment of inflammation and pain associated with musculoskeletal and joint disorders such as rheumatoid arthritis and osteoarthritis, as well as acute gout, ankylosing spondylitis, and other inflammatory conditions. It is also used to treat non-neuropathic pain and dysmenorrhea. Lidocaine hydrochloride is primarily used as a local anesthetic, and is indicated for local or regional anesthesia blocks, infiltration anesthesia, conduction anesthesia for diagnostic and minor surgical procedures on the skin, and for general endotracheal, tracheal, bronchial, and laryngeal anesthesia. It is also used as an antiarrhythmic to treat and prevent certain types of life-threatening cardiac arrhythmias such as ventricular fibrillation.

Mechanism Of Action

The mechanism of action of Diclofenac Sodium and Lidocaine Hydrochloride is related to their individual actions. Diclofenac Sodium is a non-selective inhibitor of the enzyme cyclooxygenase (COX), preventing the formation of inflammatory mediators such as prostaglandins and thromboxanes. This reduces inflammation and pain. Lidocaine hydrochloride acts as a local anesthetic by blocking sodium channels on nerve cells and preventing the conduction of nerve signals, thus causing local analgesia. It also reduces arrhythmias by blocking the inward movement of sodium ions through the voltage-gated sodium channels in the heart.

How Long Does It Take To Work

The effects of Diclofenac Sodium and Lidocaine Hydrochloride usually start within 15 minutes of administration and reach their peak effects at about 1-2 hours. The analgesic and anti-inflammatory effects of diclofenac sodium may last for 8-12 hours. The anesthetic effects of lidocaine hydrochloride can last for 1-4 hours.

Absorption

Diclofenac Sodium and Lidocaine Hydrochloride are both rapidly absorbed after oral administration. Diclofenac Sodium is rapidly and completely absorbed with peak concentrations reached in 1-2 hours and the bioavailability of 90%. Lidocaine hydrochloride is also rapidly and completely absorbed with peak concentrations reached in 30 minutes. The bioavailability for lidocaine is 100%.

Route Of Elimination

Diclofenac Sodium and Lidocaine Hydrochloride are both eliminated primarily through the kidneys, either unchanged or as metabolites. About 60-87% of a dose of diclofenac sodium is eliminated in 24 hours, while about 70% of lidocaine is eliminated in 14 hours.

Dosage

Adult: One ampoule once (or in severe cases, twice) daily by intramuscular injection.

Renal colic: One ampoule once daily intramuscularly. A second dose may be administered after 30 minutes if necessary.

Children: In Juvenile chronic arthritis, 1-3 mg of Diclofenac Sodium per kg body weight daily in divided doses.

Elderly patients: In elderly or debilitated patients, the lowest effective dosage is recommended, commensurate with age and physical status, or as prescribed by the physician. The dose of Diclofenac Sodium and Lidocaine Hydrochloride depends on the indication, age, and weight of the patient. In adults, diclofenac sodium is usually given in tablets, capsules, or solutions containing 25-50 mg every 8-12 hours or 75-100 mg twice daily. Lidocaine hydrochloride is usually given as an injection containing 5-50 mg per kg bodyweight depending on the indication. The usual dose for local anesthesia is 0.5-1 mg/kg.

Administration

Diclofenac Sodium and Lidocaine Hydrochloride can be administered orally, intramuscularly, or IV. Diclofenac sodium is usually administered orally in the form of tablets, capsules, or solutions. Lidocaine hydrochloride is usually administered intravenously, intramuscularly or as a topical solution.

Side Effects

Common side effects of Diclofenac Sodium and Lidocaine Hydrochloride include headache, dizziness, drowsiness, stomach pain, nausea, diarrhea, vomiting, rash, blurred vision, dry mouth, and constipation. Serious side effects include liver damage, kidney injury, heart damage, and anaphylaxis.

Toxicity

The toxicity of Diclofenac Sodium and Lidocaine Hydrochloride depends on the dose and individual response. Higher doses may cause serious adverse effects including liver, kidney, and heart damage. Toxicity can also occur due to overdosage or sensitivity to either medication. Severe anaphylaxis may occur in certain individuals.

Precaution

Before taking Diclofenac Sodium and Lidocaine Hydrochloride, patients should inform their doctor of their current medical history and any other medications or supplements they are taking. Patients should also inform their doctor if they are allergic to any ingredients in either medication. Patients with a history of heart, liver, or kidney disease, or any other serious medical condition should consult their doctor before taking this medication.

Interaction

Diclofenac Sodium and Lidocaine Hydrochloride can interact with other medications and supplements. It should not be used with blood thinners, steroids, or diuretics. It should also not be used with other NSAIDs, opioids, or MAOIs. It is important to tell your doctor about all medications and supplements you are taking to avoid any dangerous interactions.

Disease Interaction

Diclofenac Sodium and Lidocaine Hydrochloride may interact with certain diseases. In patients with kidney, liver, or heart disease, this medication should be used with caution as it may worsen the condition or cause serious adverse effects. In patients with asthma, it should be used with caution as it may cause anaphylaxis. In pregnant or lactating mothers, it should be used with caution as the safety of the medication in these groups of people has not yet been established.

Drug Interaction

Diclofenac Sodium and Lidocaine Hydrochloride may interact with other medications, either increasing or decreasing their effectiveness. This medication should not be used with other NSAIDs, blood thinners, opioids, steroids, MAOIs, or diuretics as this may increase the risk of serious adverse effects. It is important to inform the doctor of all medications and supplements you are taking to avoid any dangerous interactions.

Food Interactions

Diclofenac Sodium and Lidocaine Hydrochloride may interact with some foods, either increasing or decreasing the effectiveness of the medication. This medication should be taken with food to avoid gastric irritation. It should also be taken at least 30 minutes before or two hours after a meal. It should not be taken with alcohol or caffeine as this may increase the risk of side effects.

Pregnancy Use

Diclofenac Sodium and Lidocaine Hydrochloride should be used with caution in pregnant women as it may increase the risk of serious adverse effects in the fetus and newborn. It should only be used if the potential benefits outweigh the risks.

Lactation Use

Diclofenac Sodium and Lidocaine Hydrochloride should be used with caution in breastfeeding women as it may pass into breast milk and cause adverse effects in the infant. It should only be used if the potential benefits outweigh the risks.

Acute Overdose

An acute overdose of Diclofenac Sodium and Lidocaine Hydrochloride can be life-threatening and should be treated as soon as possible. Symptoms of overdose can include nausea, vomiting, irregular heartbeats, confusion, seizures, and coma.

Contraindication

Diclofenac Sodium and Lidocaine Hydrochloride are contraindicated in patients with hypersensitivity to any of their ingredients. It should also not be used in patients with a history of heart, liver, or kidney disease, asthma, or bleeding disorders.

Use Direction

Diclofenac Sodium and Lidocaine Hydrochloride should be used exactly as prescribed by the doctor. The dose and route of

See in details version Anodyne Plus IM Injection (75 mg+20 mg)/2 ml also Anodyne Plus IM Injection (75 mg+20 mg)/2 ml in bangla

Social card

Some Frequently Asked Questions About Anodyne Plus IM Injection (75 mg+20 mg)/2 ml

1. What is Anodyne Plus IM Injection (75 mg+20 mg)/2 ml?

Anodyne Plus IM Injection (75 mg+20 mg)/2 ml is a combination medication used for the topical treatment of pain and inflammation associated with musculoskeletal conditions, such as muscle strains, sprains, and osteoarthritis.

2. How does Anodyne Plus IM Injection (75 mg+20 mg)/2 ml work?

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and pain. Lidocaine Hydrochloride is a local anesthetic that numbs the area to provide pain relief.

3. What conditions are treated with Anodyne Plus IM Injection (75 mg+20 mg)/2 ml?

This combination is typically used to treat:

• Musculoskeletal pain
• Arthritis pain
• Muscle sprains and strains
• Joint pain

4. How is Anodyne Plus IM Injection (75 mg+20 mg)/2 ml applied?

The combination is usually applied topically as a gel, cream, or patch to the affected area. Follow the instructions provided by your healthcare provider for proper application.

5. What is the usual dosage of Anodyne Plus IM Injection (75 mg+20 mg)/2 ml?

The typical dosage is to apply a thin layer of the medication to the affected area up to four times a day, but your doctor may adjust the dosage based on your condition.

6. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used on broken skin?

No, this medication should not be applied to broken or irritated skin. Avoid contact with open wounds or mucous membranes.

7. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for back pain?

Yes, this combination can be used to treat back pain caused by inflammation or muscle strains.

8. Are there any side effects of Anodyne Plus IM Injection (75 mg+20 mg)/2 ml?

Common side effects may include:

• Skin irritation
• Redness or itching at the application site
• Rash
• Dizziness

9. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for neck pain?

Yes, this medication can be applied to the neck area to relieve pain and inflammation associated with muscle strains or other musculoskeletal conditions.

10. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml cause an allergic reaction?

Yes, allergic reactions can occur, including symptoms like swelling, rash, or difficulty breathing. Seek medical attention immediately if you experience any signs of an allergic reaction.

11. How quickly does Anodyne Plus IM Injection (75 mg+20 mg)/2 ml work?

Anodyne Plus IM Injection (75 mg+20 mg)/2 ml starts providing relief within a short time after application, usually within 30 minutes to an hour, though the full effect may take longer.

12. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for knee pain?

Yes, this combination can help reduce pain and inflammation associated with knee pain, especially in conditions like arthritis or injury.

13. Can I use Anodyne Plus IM Injection (75 mg+20 mg)/2 ml with other topical medications?

It is important to consult your doctor before using other topical medications along with Anodyne Plus IM Injection (75 mg+20 mg)/2 ml to avoid interactions.

14. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for shoulder pain?

Yes, this medication can be used to relieve pain and inflammation associated with shoulder pain, such as from muscle strains or injuries.

15. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml cause skin irritation?

Yes, skin irritation is a possible side effect. If irritation occurs, discontinue use and consult your doctor for alternatives.

16. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for osteoarthritis?

Yes, it is effective for treating the pain and inflammation caused by osteoarthritis, particularly in the joints.

17. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for tendonitis?

Yes, this combination can be used to treat pain and inflammation associated with tendonitis.

18. How should Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be stored?

Store the medication at room temperature, away from heat and moisture, and keep it out of the reach of children.

19. What should I do if I miss a dose of Anodyne Plus IM Injection (75 mg+20 mg)/2 ml?

If you miss a dose, apply the medication as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule.

20. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for headaches?

No, this combination is not used for headache relief. It is intended for musculoskeletal pain and inflammation.

21. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used during pregnancy?

It is not recommended to use this medication during pregnancy, especially in the third trimester, unless prescribed by your doctor. Consult your healthcare provider before using it during pregnancy.

22. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used during breastfeeding?

Consult your doctor before using this medication while breastfeeding, as the safety of its use during lactation is not fully established.

23. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for sports injuries?

Yes, this combination can be used to relieve pain and inflammation caused by sports injuries such as sprains and strains.

24. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be applied to the face?

It is not recommended to apply this medication to the face, especially near the eyes or mucous membranes. Always follow your doctor’s instructions on application areas.

25. Is Anodyne Plus IM Injection (75 mg+20 mg)/2 ml effective for nerve pain?

While this combination can help reduce inflammation and pain, it is more commonly used for musculoskeletal pain rather than nerve pain.

26. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml cause dizziness?

Yes, dizziness can occur as a side effect, particularly if too much medication is applied. If you experience dizziness, avoid driving or operating heavy machinery.

27. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for sciatica?

Yes, it can be used to alleviate the pain and inflammation associated with sciatica, as it targets both the inflammation and local pain.

28. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml cause an overdose?

An overdose is unlikely with topical application, but applying more than the recommended amount can increase the risk of side effects. Follow the prescribed dosage strictly.

29. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml interact with other medications?

Yes, Anodyne Plus IM Injection (75 mg+20 mg)/2 ml may interact with other medications. Inform your healthcare provider of all medications you are taking.

30. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml cause weight gain?

Weight gain is not a common side effect of this medication. However, fluid retention can occur, which may lead to swelling in some people.

31. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for fibromyalgia?

This medication may provide relief from pain associated with fibromyalgia, but it should be used as part of a comprehensive treatment plan.

32. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for pain after surgery?

Yes, it can be used to relieve post-surgical pain and inflammation, especially for musculoskeletal surgeries.

33. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for rheumatoid arthritis?

Yes, it can help reduce pain and inflammation associated with rheumatoid arthritis, especially for localized flare-ups.

34. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for ankle pain?

Yes, it is effective for treating ankle pain due to inflammation, sprains, or strains.

35. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for bursitis?

Yes, it can be used to relieve the pain and inflammation associated with bursitis.

36. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml cause heart problems?

While rare, long-term use of Diclofenac Sodium (one of the ingredients) may increase the risk of heart problems. Consult your doctor for proper use.

37. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for muscle cramps?

Yes, this combination can provide relief from muscle cramps by reducing muscle inflammation and pain.

38. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml cause a rash?

Yes, a rash may develop as a side effect. If this occurs, discontinue use and contact your healthcare provider.

39. Is Anodyne Plus IM Injection (75 mg+20 mg)/2 ml addictive?

No, Anodyne Plus IM Injection (75 mg+20 mg)/2 ml is not addictive as it is a topical medication that does not contain habit-forming substances.

40. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for neck stiffness?

Yes, it can be applied to relieve neck stiffness caused by muscle strain or injury.

41. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for pain during physical therapy?

Yes, it can help manage pain and inflammation that may arise during physical therapy sessions.

42. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for jaw pain?

Yes, it can be used to relieve pain from temporomandibular joint (TMJ) disorders or other musculoskeletal issues affecting the jaw.

43. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for tendinitis?

Yes, it is effective in treating the pain and inflammation associated with tendinitis.

44. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml cause headaches?

Headaches are not a common side effect, but they may occur in some people.

45. How should I apply Anodyne Plus IM Injection (75 mg+20 mg)/2 ml?

Apply a thin layer of the medication to the affected area and gently rub it in. Avoid applying to broken skin.

46. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for hip pain?

Yes, it can be used to alleviate pain and inflammation in the hip area.

47. Can I drink alcohol while using Anodyne Plus IM Injection (75 mg+20 mg)/2 ml?

It is advisable to avoid alcohol while using this medication, as it may increase the risk of side effects.

48. Can Anodyne Plus IM Injection (75 mg+20 mg)/2 ml be used for shoulder bursitis?

Yes, this combination is effective in treating pain and inflammation caused by shoulder bursitis.

49. Can I use Anodyne Plus IM Injection (75 mg+20 mg)/2 ml for a muscle strain?

Yes, it is highly effective in treating muscle strains by reducing inflammation and providing localized pain relief.

50. What should I do if I experience severe side effects from Anodyne Plus IM Injection (75 mg+20 mg)/2 ml?

If you experience severe side effects like difficulty breathing, swelling, or severe skin reactions, seek emergency medical attention immediately.