Angitan Plus Tablet

Introduction

Losartan Potassium and Hydrochlorothiazide is a combination medication that is used to treat high blood pressure (hypertension). The medication works by blocking a natural chemical in the body that causes blood vessels to tighten and relaxes the vessels to help lower blood pressure.

Uses for

Losartan Potassium and Hydrochlorothiazide is used to treat high blood pressure. It is also used to decrease the risk of stroke in people with high blood pressure and an enlarged heart.

Brand Name	Angitan Plus
Type	Tablet
Weight	50 mg+12.5 mg
Generic	Losartan Potassium + Hydrochlorothiazide
Manufacturer	Chemist Laboratories Ltd.
Available in	English বাংলা

Mechanism of Action

Losartan Potassium and Hydrochlorothiazide works by blocking a natural chemical that causes blood vessels to tighten and relaxes the vessels, thus helping to lower blood pressure. Hydrochlorothiazide works by decreasing the amount of fluid (urine) in the body and retaining salt and potassium, which helps to reduce high blood pressure.

How Long Does it Take to Work?

Losartan Potassium and Hydrochlorothiazide generally begins to work within 1 to 4 weeks, but it may take longer for some people to see the full effects.

Absorption

Losartan Potassium and Hydrochlorothiazide is rapidly and completely absorbed from the gastrointestinal tract.

Route of Elimination

The medication is eliminated primarily in the urine.

Dosage

Hypertension-

The usual starting dose of this combination 50/12.5 is one tablet once daily.
For patients who do not respond adequately to one tablet the dosage may be increased to 100/25 once daily.
A patient whose blood pressure is not adequately controlled with Losartan 100 mg monotherapy may be switched to this combination 100/12.5 once daily.
In hypertensive patients with left ventricular hypertrophy initial dose is 50/12.5, if additional blood pressure reduction is needed, 100/12.5 may be given, followed by 100/25 if required. The maximum dose is 100/25 once daily.
In general, the antihypertensive effect is attained within three weeks after initiation of therapy.
No initial dosage adjustment of 50/12.5 is necessary for elderly patients. But maximum dose of 100/25 once daily dose should not be used as initial therapy in elderly patients.

Severe Hypertension:

The starting dose for initial treatment of severe hypertension is one tablet of 50/12.5 once daily.
For patients who do not respond adequately to this dose after 2 to 4 weeks of therapy, the dosage may be increased to 100/25 once daily. The maximum dose is one tablet of 100/25 once daily.

The recommended dose of Losartan Potassium and Hydrochlorothiazide is one tablet taken once daily for hypertension. Dosage may be adjusted depending on blood pressure response. The maximum recommended dose is one tablet taken once daily.

Administration

Losartan Potassium and Hydrochlorothiazide should be taken with or without food. It is important to take the dose as prescribed and regularly.

Side Effects

Common side effects of Losartan Potassium and Hydrochlorothiazide include dizziness, headache, weakness, tiredness, diarrhea, constipation, and nausea.

Toxicity

Excessive doses of Losartan Potassium and Hydrochlorothiazide can lead to severe hypotension or electrolyte imbalance.

Precautions

Before using Losartan Potassium and Hydrochlorothiazide, your healthcare provider will need to know about any medical conditions you have, especially heart or kidney problems.

Interactions

Losartan Potassium and Hydrochlorothiazide may interact with other medications you are taking, including medications for high blood pressure, medications to prevent blood clots, diuretics, and other medications for heart failure.

Disease Interaction

Patients with diabetes or kidney disease should use Losartan Potassium and Hydrochlorothiazide with caution. People with a history of liver disease may need monitoring while taking the medication. People with decreased urinary flow should also use the medication with caution.

Drug Interactions

Food Interactions

Food does not appear to affect the absorption of Losartan Potassium and Hydrochlorothiazide.

Pregnancy Use

It is unknown if Losartan Potassium and Hydrochlorothiazide is safe for use in pregnant women.

Lactation Use

It is unknown if Losartan Potassium and Hydrochlorothiazide is secreted in human breast milk.

Acute Overdose

An acute overdose of Losartan Potassium and Hydrochlorothiazide may cause hypotension, electrolyte imbalance, and other potentially serious adverse effects.

Contraindication

Losartan Potassium and Hydrochlorothiazide is contraindicated in people who are hypersensitive to any of its components, people with anuria or acute renal insufficiency, and in patients who have a history of angioedema while taking an ACE inhibitor.

Use Direction

Losartan Potassium and Hydrochlorothiazide should be taken orally with or without food as prescribed by your healthcare provider. Dosage may need to be adjusted depending on your blood pressure response.