Anastrozole

Anastrozole Introduction

Anastrozole is an oral drug in a class called aromatase inhibitors. Aromatase is an enzyme that helps to convert androgens (such as testosterone) into estrogens. Anastrozole works by blocking this enzyme, thereby reducing the amount of estrogen in the body. By doing this, it is thought to benefit conditions in women in menopause where estrogen levels are significantly increased.

Uses for Anastrozole

Anastrozole is used primarily to treat prostate cancer, endometriosis, and some forms of breast cancer. It can also be used to reduce the risk of developing breast cancer in high risk individuals. High risk individuals are typically those with a family history of breast cancer or a previous diagnosis of ductal carcinoma in situ. Additionally, some studies suggest that it can be used to reduce the risk of breast cancer recurrence in postmenopausal women who have already had the disease. The drug is FDA approved for any of these uses.

Brand Name	Anastrozole
Type
Weight
Generic	Anastrozole
Manufacturer
Available in	English বাংলা

Mechanism of Action

Anastrozole works by blocking the enzyme aromatase, which is responsible for converting androgens such as testosterone into estrogens, such as estradiol. Blocking the action of this enzyme can reduce the amount of estrogen in the body, which can be beneficial in cases where the person has elevated levels of estrogen. By doing this, Anastrozole can reduce the risk of developing or worsening a condition related to excess estrogen.

How Long Does it Take to Work?

It typically takes about 4 weeks for Anastrozole to take effect. However, the effects can be seen sooner in some people. After 4 weeks, the amount of estrogen produced by the body is significantly lower than it was at baseline.

Absorption

Anastrozole is rapidly absorbed in the gastrointestinal tract. Peak concentrations are reached within two hours after the administration of the drug.

Route of Elimination

The primary route of elimination is through the feces, where approximately 70 % of the administered dose is excreted. The remainder is primarily excreted unchanged in the urine.

Dosage

The dose of Anastrozole is one tablet 1 mg taken once a day. For patients with advanced breast cancer, Anastrozole should be continued until tumor progression. For adjuvant treatment of early breast cancer in postmenonausal women, the optimal duration of therapy is unknown.

Patients with Hepatic Impairment: No changes in dose are recommended for patients with mild-to-moderate hepatic impairment. Anastrozole has not been studied in patients with severe hepatic impairment.

Patients with Renal Impairment: No changes in dose are necessary for patients with renal impairment.

Pediatric Use: The safety and efficacy of Anastrozole in pediatric patients have not been established.

Geriatric Use: The pharmacokinetics of Anastrozole are not affected by age.

The recommended dose of Anastrozole is one 1 mg tablet once daily. It can be taken with or without food. It is important to take it regularly and consistently, as the effects of the medication can take some time to become apparent.

Administration

Anastrozole should be taken as directed by your doctor. The tablets should be swallowed with a full glass of water and should be taken at the same time each day.

Side Effect

Common side effects of Anastrozole include hot flashes, night sweats, headache, nausea, fatigue, joint pain, and hair loss. Less common side effects include depression, insomnia, and rash.

Toxicity

High doses of Anastrozole can cause toxicity. Symptoms of toxicity include nausea, vomiting, fatigue, shortness of breath, and dizziness. If any of these symptoms occur, you should seek medical attention immediately.

Precautions

Before taking Anastrozole , tell your doctor if you have any allergies or if you are taking any other medications. Additionally, tell your doctor if you have a history of liver or kidney disease, or if you are pregnant or planning to become pregnant. It is important to avoid drinking alcohol while taking Anastrozole .

Interactions

Anastrozole may interact with other medications. Before taking the medication, tell your doctor about all the medications you are currently taking, including over-the-counter medications, vitamins, and herbal supplements.

Disease Interaction

Anastrozole can interact with certain diseases. Tell your doctor if you have any other medical conditions, such as heart disease, liver or kidney disease, or a history of stroke. Anastrozole can interact with conditions such as these, so it is important to discuss them with your doctor before starting the medication.

Drug Interaction

Certain drugs can interact with Anastrozole , including warfarin, rifampin, and phenytoin. Talk to your doctor before starting Anastrozole if you are currently taking any of these medications.

Food Interactions

Anastrozole is not known to interact with food. However, it is important to make sure you are taking your medication at the same time each day.

Pregnancy Use

Anastrozole is not recommended for use during pregnancy. Studies have not been conducted to determine if the drug is safe for unborn babies. Women who are pregnant or planning a pregnancy should talk to their doctor before starting Anastrozole .

Lactation Use

Anastrozole is not recommended for use while breast feeding. It is unknown if the drug passes into breast milk. Women who are nursing or plan to nurse should talk to their doctor before taking Anastrozole .

Acute Overdose

Acute overdose of Anastrozole can occur if too much of the drug is taken at one time. Symptoms of an overdose can include fatigue, nausea, vomiting, diarrhea, and abdominal pain. If you experience any of these symptoms, seek medical attention immediately.

Contraindication

Though Anastrozole is generally well tolerated, it is not recommended for use in people with certain medical conditions, such as those with a history of liver or kidney disease. It is also not recommended for those who are pregnant or breast feeding. Additionally, it is not recommended for those who have had an allergic reaction to aromatase inhibitors.

Use Direction

Anastrozole should be taken as directed by your doctor. Take one tablet once a day with or without food. Do not chew, crush, or split the tablets. Do not take the pill more than once a day. If you forget to take a dose, take it as soon as you remember and then take your next dose at the same time the next day.

Storage Condition

Anastrozole should be stored at room temperature away from light and moisture. Keep out of the reach of children and pets.

Volume of Distribution

Anastrozole has an estimated volume of distribution of 14 to 17 L/Kg.

Half Life

Anastrozole has an estimated half-life of 40 to 50 hours.

Clearance

Anastrozole has an estimated clearance of 38 to 48 mL/minute.

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Some Frequently Asked Questions About Anastrozole