Alverate Tablet

Introduction

Alverate Tablet 60 mg is a medication primarily used to relieve symptoms associated with irritable bowel syndrome (IBS) and other functional gastrointestinal disorders. It is classified as an antispasmodic agent, which helps in alleviating smooth muscle spasms in the gastrointestinal tract.

Uses

Alverate Tablet 60 mg is used to:

Relieve abdominal pain and discomfort caused by irritable bowel syndrome (IBS).
Alleviate symptoms of other functional gastrointestinal disorders, such as spastic colon and functional dyspepsia.
Reduce the frequency and severity of smooth muscle spasms in the gastrointestinal tract.

Brand Name	Alverate
Type	Tablet
Weight	60 mg
Generic	Alverine Citrate
Manufacturer	Ibn Sina Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Alverate Tablet 60 mg works by relaxing the smooth muscles of the gastrointestinal tract. It acts on the smooth muscle cells by inhibiting the calcium influx necessary for muscle contraction. This reduces the spasms and pain associated with conditions like IBS.

How Long Does It Take to Work?

The onset of action for Alverate Tablet 60 mg is typically within 30 to 60 minutes after oral administration. Symptom relief, including reduction in abdominal pain and discomfort, may be observed within this time frame. Full therapeutic effects are usually experienced after several days of consistent use.

Absorption

Alverate Tablet 60 mg is well absorbed from the gastrointestinal tract after oral administration. The drug reaches peak plasma concentrations approximately 1 to 2 hours after ingestion. Food does not significantly affect the absorption of Alverate Tablet 60 mg.

Route of Elimination

Alverate Tablet 60 mg is metabolized in the liver, and its metabolites are excreted primarily in the urine. A small amount of the drug may be excreted in the feces. The rate of elimination can be influenced by liver function and renal health.

Dosage

Adult: Orally: 60-120 mg 1-3 times daily.

The recommended dosage of Alverate Tablet 60 mg is:

Adults: 60 mg to 120 mg, taken 3 times daily before meals. The dosage may be adjusted based on patient response and tolerance.
Children: Safety and efficacy in children have not been established; therefore, use in pediatric patients is not generally recommended.

Administration

Alverate Tablet 60 mg should be taken orally with a glass of water. It is recommended to take the medication before meals to maximize its efficacy in reducing gastrointestinal symptoms. Consistent use as prescribed by a healthcare provider is important for achieving optimal results.

Side Effects

Common side effects of Alverate Tablet 60 mg include:

Abdominal discomfort
Diarrhea
Headache
Nausea

Serious side effects may include:

Allergic reactions (e.g., rash, itching, swelling)
Severe abdominal pain
Persistent or worsening gastrointestinal symptoms

Toxicity

In cases of overdose or excessive use of Alverate Tablet 60 mg, symptoms may include severe gastrointestinal discomfort, nausea, and vomiting. Management involves discontinuing the medication and providing symptomatic and supportive care. Gastric lavage and activated charcoal may be considered in severe cases.

Precautions

Precautions should be taken in patients with:

Severe liver or renal impairment
History of gastrointestinal disorders
Known hypersensitivity to Alverate Tablet 60 mg or any of its components

Regular monitoring is advised to ensure the medication is well-tolerated and effective.

Interaction

Alverate Tablet 60 mg may interact with:

Other antispasmodics: Concurrent use may enhance antispasmodic effects, potentially leading to increased side effects.
Antacids: May affect the absorption of Alverate Tablet 60 mg, although this interaction is generally minimal.

Disease Interaction

Use Alverate Tablet 60 mg with caution in patients with:

Gastrointestinal obstruction or severe constipation
Active gastrointestinal bleeding
Renal or hepatic impairment

Drug Interaction

Drug interactions with Alverate Tablet 60 mg are relatively few. However, potential interactions include:

Anticholinergic drugs: May have additive antispasmodic effects.
Other medications affecting gastrointestinal motility: May alter the effectiveness of Alverate Tablet 60 mg.

Food Interactions

There are no significant food interactions with Alverate Tablet 60 mg. It is generally recommended to take the medication before meals, but food intake does not substantially alter its efficacy.

Pregnancy Use

Alverate Tablet 60 mg is classified as pregnancy category B. It should be used during pregnancy only if clearly needed. The drug's safety during pregnancy has not been fully established, so it should be used under medical supervision with a careful risk-benefit assessment.

Lactation Use

Alverate Tablet 60 mg is excreted in breast milk in small amounts. While it is generally considered safe for use during lactation, caution is advised. Monitor for any potential adverse effects in the nursing infant, and consult a healthcare provider if concerns arise.

Acute Overdose

Acute overdose of Alverate Tablet 60 mg may result in severe gastrointestinal symptoms, including pain, nausea, and vomiting. Management involves discontinuing the medication and providing supportive care. In severe cases, medical intervention may be required.

Contraindication

Alverate Tablet 60 mg is contraindicated in patients with:

Hypersensitivity to Alverate Tablet 60 mg or any of its components
Severe gastrointestinal obstruction or conditions that could be exacerbated by smooth muscle relaxation
Severe liver or renal impairment where drug metabolism or excretion could be significantly impaired

Use Direction

Alverate Tablet 60 mg should be used according to the prescribed dosage and administration instructions. Take the medication before meals, and follow the healthcare provider’s recommendations for duration and frequency of use. Adhere to the dosage instructions to avoid potential side effects and ensure effectiveness.

Storage Conditions

Store Alverate Tablet 60 mg at room temperature, between 20°C and 25°C (68°F and 77°F). Protect from light and moisture. Keep the medication tightly closed and out of reach of children.

Volume of Distribution

The volume of distribution of Alverate Tablet 60 mg is not well-documented but is generally low due to its limited systemic absorption. Most of the drug remains within the gastrointestinal tract where it exerts its therapeutic effects.

Half Life

The plasma half-life of Alverate Tablet 60 mg is approximately 2 to 4 hours. The drug's effects on smooth muscle relaxation last longer than its presence in the plasma due to its local action and metabolism.

Clearance

Alverate Tablet 60 mg is primarily metabolized by the liver and cleared through the urine. The clearance rate may be affected by liver or renal impairment. Regular monitoring may be needed for patients with significant hepatic or renal conditions.

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