Alergix MR Tablet (Modified Release)

Introduction

Alergix MR Tablet (Modified Release) 10 mg is a second-generation antihistamine used to treat allergic conditions such as seasonal allergic rhinitis and chronic urticaria. As a non-sedative antihistamine, it blocks the action of histamine, reducing symptoms like itching, swelling, and redness without causing significant drowsiness.

Uses

Alergix MR Tablet (Modified Release) 10 mg is commonly prescribed for:

Treatment of seasonal allergic rhinitis (hay fever)
Management of chronic idiopathic urticaria (hives)
Relief from allergic symptoms like itching, sneezing, and runny nose

Brand Name	Alergix MR
Type	Tablet (Modified Release)
Weight	10 mg
Generic	Mizolastine
Manufacturer	Incepta Pharmaceuticals Ltd.
Available in	English বাংলা

Mechanism of Action

Alergix MR Tablet (Modified Release) 10 mg works by selectively blocking histamine H1 receptors, preventing the release of histamine from mast cells and basophils during allergic reactions. This reduces the inflammatory response associated with histamine, alleviating symptoms such as itching, swelling, and nasal congestion.

How Long Does It Take to Work?

Alergix MR Tablet (Modified Release) 10 mg typically starts working within 1 to 2 hours of oral administration, providing relief from allergic symptoms. The effects usually last for 24 hours, making it suitable for once-daily dosing.

Absorption

Alergix MR Tablet (Modified Release) 10 mg is well absorbed from the gastrointestinal tract after oral administration. It reaches peak plasma concentrations in about 1 to 2 hours. The bioavailability of mizolastine is approximately 65% to 75%.

Route of Elimination

Alergix MR Tablet (Modified Release) 10 mg is metabolized in the liver and primarily excreted via the feces. A smaller percentage is eliminated through the urine as metabolites. Its clearance is largely dependent on hepatic metabolism.

Dosage

Adult and children above 12 years: The usual recommended dose is one 10 mg tablet daily.
Children below 12 years: Not recommended.

The usual dose of mizolastine for adults and children over 12 years of age is 10 mg once daily. It is generally taken orally, with or without food. Dosage adjustments may be necessary in patients with liver or kidney impairment.

Administration

Alergix MR Tablet (Modified Release) 10 mg is taken orally as a tablet, usually once a day. It can be taken with or without food, but taking it with a meal may reduce potential gastrointestinal side effects. Swallow the tablet whole with water.

Side Effects

Common side effects of mizolastine include:

Headache
Drowsiness
Dizziness
Nausea
Dry mouth

Serious but rare side effects include:

Allergic reactions (rash, itching, swelling)
Severe dizziness or fainting (in case of overdose or hypersensitivity)

Toxicity

In cases of overdose, mizolastine can cause severe drowsiness, headache, and dizziness. Extreme cases may lead to heart-related issues, particularly in patients with a predisposed cardiac condition. Overdose management includes symptomatic treatment and supportive care.

Precautions

Precautions to consider with mizolastine use include:

Use caution in patients with hepatic or renal impairment
Avoid use in patients with a known history of cardiac arrhythmias or prolonged QT interval
Avoid alcohol, which can increase dizziness or drowsiness
Use cautiously in elderly patients who may be more sensitive to its effects

Interaction

Alergix MR Tablet (Modified Release) 10 mg may interact with:

Drugs that prolong the QT interval (e.g., certain antiarrhythmics)
Macrolide antibiotics (e.g., erythromycin), which can increase the risk of cardiac side effects
Ketoconazole and other antifungal agents that may increase plasma levels of mizolastine

Disease Interaction

Alergix MR Tablet (Modified Release) 10 mg should be used with caution in patients with:

Liver or kidney impairment
Cardiac conditions such as prolonged QT interval
Electrolyte imbalances, particularly hypokalemia

Drug Interaction

Alergix MR Tablet (Modified Release) 10 mg can interact with:

Ketoconazole and itraconazole: Increased risk of QT prolongation
Macrolide antibiotics (e.g., erythromycin): May increase the concentration of mizolastine
Antihypertensives: May enhance the sedative effect
Other H1 antagonists: Combination may lead to increased sedation

Food Interactions

Food can delay the absorption of mizolastine slightly, but it does not significantly affect its overall bioavailability. Avoid alcohol consumption while taking mizolastine, as it can increase the risk of drowsiness and dizziness.

Pregnancy Use

There is limited data on the use of mizolastine during pregnancy. It should only be used during pregnancy if the potential benefits outweigh the risks. Consult a healthcare provider before using mizolastine if you are pregnant.

Lactation Use

It is not known whether mizolastine is excreted in human breast milk. Caution should be exercised, and a healthcare provider should be consulted before using mizolastine during breastfeeding.

Acute Overdose

Symptoms of overdose may include excessive drowsiness, dizziness, and headache. In more severe cases, overdose may lead to cardiac arrhythmias. Treatment is supportive and may include activated charcoal and monitoring of vital signs. Gastric lavage may be considered in recent ingestions.

Contraindication

Alergix MR Tablet (Modified Release) 10 mg is contraindicated in patients with:

Known hypersensitivity to mizolastine or any of its components
Severe liver or kidney impairment
Prolonged QT interval or other pre-existing cardiac conditions

Use Direction

Alergix MR Tablet (Modified Release) 10 mg should be taken exactly as prescribed by a healthcare provider. The standard dosing is once daily, and the tablet should be swallowed whole with water. Do not exceed the recommended dosage.

Storage Conditions

Store mizolastine at room temperature, away from moisture, heat, and direct light. Keep it in a tightly sealed container and out of reach of children. Do not store in the bathroom.

Volume of Distribution

The volume of distribution of mizolastine is approximately 1.2 to 1.5 L/kg, indicating its wide distribution throughout body tissues.

Half Life

The elimination half-life of mizolastine is approximately 13 to 16 hours, allowing for once-daily dosing in the management of allergic symptoms.

Clearance

Alergix MR Tablet (Modified Release) 10 mg is primarily metabolized in the liver and cleared through fecal excretion, with a smaller portion eliminated through urine. Hepatic function largely influences its clearance rate.

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