AFM-Plus Ophthalmic Ointment

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Introduction

Fluorometholone + gentamicin is a combination of medicines used to treat eye infections. Fluorometholone is a synthetic, steroidal glucocorticoid and an anti-inflammatory agent while gentamicin is an aminoglycoside antibiotic. This combination is used to treat bacterial infections of the eye such as eye conjunctivitis, keratitis, and anterior uveitis.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Uses

Fluorometholone + gentamicin is used to treat bacterial eye infections such as conjunctivitis, keratitis, and anterior uveitis. It is also used for other inflammatory and allergic conditions of the eye.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Mechanism of Action

Fluorometholone is a glucocorticoid which acts by mimicking the action of endogenous glucocorticoids like cortisol. It has anti-inflammatory and Vasoconstrictive action which helps in reducing swelling and pain. Gentamicin is an aminoglycoside antibiotic which kills bacteria by inhibiting bacterial protein synthesis and disrupting bacterial cell membranes.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: How Long Does It Take to Work?

Fluorometholone + gentamicin takes about two to four weeks to show improvement in the symptoms of eye infections.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Absorption

Fluorometholone is absorbed through the ocular route.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Route of Elimination

Fluorometholone is excreted through the renal route. Gentamicin is excreted through the renal route as well as through the ocular route.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Dosage

The dose of Fluorometholone + gentamicin depends on the condition of the patient. The usual recommended dose is 10 mg/ml (0.1%) Fluorometholone + 1 mg/ml (0.1%) gentamicin solution given 1-2 times a day.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Administration

Fluorometholone + gentamicin drops can be directly administered into the eye with the help of a dropper or it can be administered through a soft facial tissue placed over the eye.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Side Effects

The common side effects associated with Fluorometholone + gentamicin drops include irritation, burning, redness, and stinging in the eyes. Other rare side effects include headache, nausea, dizziness, blurred vision, and photophobia.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Toxicity

Fluorometholone + gentamicin, when taken in high doses, can be toxic to the body. There may be an increase in the risk of red cell destruction, renal damage, hearing impairment, and vertigo if taken in high doses.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Precaution

Fluorometholone + gentamicin should not be used in patients with a history of allergic reactions, eye infections, renal dysfunction, or with neurological disorders. It should also be used with caution in pregnant and lactating women.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Interaction

Fluorometholone + gentamicin may interact with other drugs like diuretics, anticoagulants, and drugs metabolized through the cytochrome P450 pathway.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Disease Interaction

Fluorometholone + gentamicin may interact with certain diseases like hypoglycemia, diabetes, hypothyroidism, glaucoma, and fungal infections.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Drug Interaction

Fluorometholone + gentamicin may interact with other drugs like antibiotics, antifungal drugs, antihistamines, and glucocorticoids.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Food Interactions

Fluorometholone + gentamicin may interact with certain food substances like alcohol, caffeine, iron, and vitamin supplements.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Pregnancy Use

Fluorometholone + gentamicin is not recommended during pregnancy as it may cause harmful side effects to the fetus.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Lactation Use

Fluorometholone + gentamicin is not recommended during lactation as it may cause harmful effects to the nursing infant.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Acute Overdose

In case of an acute overdose of Fluorometholone + gentamicin, the person should be immediately taken to a hospital and should seek medical attention.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Contraindication

Fluorometholone + gentamicin is contraindicated in patients with known hypersensitivity to steroids or gentamicin.

AFM-Plus Ophthalmic Ointment 0.1%+0.3%: Dosage Direction

Fluorometholone + gentamicin should be applied as a thin film on the eye. The drops should not be applied more than 2 times a day and the eye should not be rinsed after application.