Acepril Tablet

Acepril Tablet 10 mg Introduction

Acepril Tablet 10 mg is a commonly prescribed medication for the treatment of high blood pressure and congestive heart failure. It belongs to a group of medications known as angiotensin converting enzyme (ACE) inhibitors. This medicine may also be used in combination with other drugs to treat conditions such as kidney disease and further protect against stroke in certain individuals.

Uses For Acepril Tablet 10 mg

Acepril Tablet 10 mg is used for the following purposes:

• To treat high blood pressure.
• To treat congestive heart failure.
• To reduce the risk of stroke in certain individuals.
• To treat kidney problems caused by diabetes.

Brand Name	Acepril
Type	Tablet
Weight	10 mg
Generic	Lisinopril
Manufacturer	Drug International Ltd.
Available in	English বাংলা

Mechanism of Action

Acepril Tablet 10 mg works by blocking a specific enzyme (angiotensin converting enzyme) in the body. This prevents the production of a hormone called Angiotensin II that causes blood vessels to narrow, leading to an increase in blood pressure. By blocking this enzyme, Acepril Tablet 10 mg helps to reduce blood pressure and improve blood supply to the heart and other organs.

How Long Does it Take to Work?

Acepril Tablet 10 mg usually begins to take effect within an hour of taking the medication. It may take up to two weeks for the full effects of this drug to be seen. This varies depending on the individual and their underlying health conditions.

Absorption

Acepril Tablet 10 mg is rapidly and completely absorbed from the gastrointestinal tract. Peak concentrations of the drug are generally seen within 1 to 2 hours after administration. The overall bioavailability of the drug is approximately 80%.

Route of Elimination

Acepril Tablet 10 mg is primarily eliminated via the kidneys. About 70% to 80% of the drug is eliminated from the body within 24 hours.

Dosage

Oral (Adult)-

Hypertension: Initially, 10 mg/day, 1st dose given preferably at bedtime to avoid precipitous fall in BP. Patient with renovascular HTN, volume depletion, severe HTN: Initially, 2.5-5 mg once daily. Patient on diuretic: Initially, 5 mg once daily. Maintenance: 20 mg once daily, up to 80 mg/day may be given if needed.

Diabetic nephropathy: Hypertensive type 2 diabetics with microalbuminuria: 10 mg once daily, may increase to 20 mg once daily to achieve a sitting diastolic BP

Heart failure: As adjunct: Initially, 2.5 or 5 mg/day, increased by increments of ≤10 mg at intervals of at least 2 wk to max maintenance dose of 40 mg/day.

Post-myocardial infarction: Initially, 5 mg once daily for 2 days started within 24 hr of the onset of symptoms. Increase to 10 mg once daily. Patients with low systolic BP: Initially, 2.5 mg once daily.

Oral (Child)-

Hypertension: ≥6 yr Initially, 0.07 mg/kg, up to 5 mg once daily.

Acepril Tablet 10 mg is available in tablets and liquid form in a range of dosages. It is usually taken once daily, with or without food. Usual adult dosages for the treatment of hypertension range from 10 mg to 40 mg, while doses for congestive heart failure generally range from 5 mg to 20 mg. These dosages may vary based on the individual patient and their underlying health conditions.

Administration

Acepril Tablet 10 mg should be taken exactly as prescribed by your doctor, with regards to timing, dosage, and overall frequency. For the tablets, swallow the pill whole with a glass of water. For the oral solution, dilute the dosage with 4 ounces (120 mL) of water, apple juice, or orange juice before consuming. Do not mix the medication with other liquids.

Side Effects

Common reported side effects include:

• Dizziness
• Headache
• Fatigue
• Nausea
• Coughing

Toxicity

Overdose of lisinopril can cause a drop in blood pressure, which can lead to Loss of consciousness, shallow breathing, seizures, and cardiac arrest. If an overdose is suspected, seek medical attention immediately.

Precaution

If you are allergic to lisinopril, have had a recent heart attack, or are pregnant or breastfeeding, tell your doctor before starting on lisinopril. Some people may have a particularly low levels of sodium or potassium in their body, and so they may need to have their electrolytes monitored while taking lisinopril. If you have any kidney problems or a history of heart problems, then lisinopril may not be suitable for you.

Interaction

Acepril Tablet 10 mg can interact with a variety of medications, including but not limited to aspirin, potassium-sparing diuretics, non-steroidal anti-inflammatory drugs (NSAIDs), and potassium supplements. Drinking alcohol while on lisinopril may increase your risk of experiencing certain side effects. Therefore, it is best to avoid alcohol if possible.

Disease Interaction

Acepril Tablet 10 mg can interact with certain diseases, such as diabetes, kidney problems, and liver disease. If you have any of these conditions, tell your doctor before starting on lisinopril. Your doctor may need to adjust your dosage or order regular blood tests to monitor your progress.

Drug Interaction

Certain drugs may interact with lisinopril, and not all interactions may be known. Examples include aspirin, potassium-sparing diuretics, non-steroidal anti-inflammatory drugs (NSAIDs), potassium supplements, ACE inhibitors, angiotensin II receptor blockers, vessels dilators, and calcium channel blockers. Tell your doctor about any other medications, supplements, or herbal products you may be taking before starting on lisinopril.

Food Interactions

There are no known food interactions with lisinopril. However, it is best to take the medication with food to reduce the risk of stomach upset.

Pregnancy Use

Acepril Tablet 10 mg falls into pregnancy category D, meaning that it can harm a developing fetus. Therefore, if you are pregnant or could become pregnant, you should avoid taking this medicine. Talk with your doctor about safe alternatives during pregnancy.

Lactation Use

Acepril Tablet 10 mg passes into breast milk and can harm an infant, so it is not recommended while breastfeeding. Talk to your doctor about your options during lactation.

Acute Overdose

If you suspect you have taken an overdose of lisinopril, seek immediate medical attention. Symptoms of overdose may include: fainting, seizures, shallow breathing, loss of consciousness, or cardiac arrest.

Contraindication

Do not take lisinopril if you are allergic to it, have had a recent heart attack, during pregnancy or breastfeeding, or if you have a history of kidney or liver problems.

Use Direction

Acepril Tablet 10 mg should be taken as directed by your doctor. Swallow the tablets whole with a glass of water. For the liquid formulation, dilute the dosage with 4 ounces (120 mL) of water, apple juice, or orange juice before consuming. Do not mix the medication with other liquids. The tablets can be taken with or without food. It is usually taken once daily.

Storage Condition

Acepril Tablet 10 mg should be stored at room temperature, away from direct light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Volume of Distribution

The volume of distribution for lisinopril is 0.87 L/kg.

Half Life

The half-life of lisinopril is 12 hours.

Clearance

The clearance rate of lisinopril is 0.075 L/hr/kg.

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Some Frequently Asked Questions About Acepril Tablet 10 mg

1. What is Acepril Tablet 10 mg?

Acepril Tablet 10 mg is a prescription medication classified as an angiotensin-converting enzyme (ACE) inhibitor. It is primarily used to treat high blood pressure (hypertension), heart failure, and to improve survival after a heart attack. By relaxing blood vessels, it lowers blood pressure and reduces the heart’s workload. It’s available as tablets under brand names like Prinivil or Zestril, or as a generic.

2. What class of drug is Acepril Tablet 10 mg?

Acepril Tablet 10 mg belongs to the ACE inhibitor class of drugs. These medications block the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby dilating blood vessels and reducing blood pressure while also decreasing fluid retention via reduced aldosterone production.

3. How does Acepril Tablet 10 mg work?

Acepril Tablet 10 mg inhibits the ACE enzyme, preventing the formation of angiotensin II. This leads to:

• Vasodilation: Widening of blood vessels, lowering blood pressure.
• Reduced aldosterone: Less sodium and water retention.
• Decreased cardiac strain: Easing the heart’s workload.

These effects help manage hypertension and support heart function.

4. What conditions does Acepril Tablet 10 mg treat?

It is used for:

• Hypertension: To control high blood pressure.
• Heart failure: To improve symptoms and heart efficiency.
• Post-myocardial infarction: To enhance survival after a heart attack.
• Kidney protection: In diabetic nephropathy to slow kidney damage.

5. Is Acepril Tablet 10 mg used for anything other than these conditions?

Yes, off-label uses include preventing migraines (though evidence is limited) and treating certain types of proteinuria or kidney disease beyond diabetes. Its primary role, however, remains cardiovascular and renal protection.

6. How is Acepril Tablet 10 mg taken?

Acepril Tablet 10 mg is taken orally as a tablet, typically once daily, with or without food. Consistency in timing (e.g., morning or evening) helps maintain stable blood levels. It’s available in strengths like 2.5 mg, 5 mg, 10 mg, 20 mg, and 40 mg.

7. What is the typical dosage for adults?

For adults:

• Hypertension: Starting dose is 10 mg daily, adjusted to 20–40 mg.
• Heart failure: Starts at 2.5–5 mg, titrated up to 20–40 mg.
• Post-heart attack: 5 mg initially, then 10 mg daily.

Maximum dose is usually 40 mg daily, tailored by a doctor.

8. What is the dosage for children?

For children (6 years and older with hypertension), the dose is weight-based: 0.07 mg/kg once daily (up to 5 mg), adjusted to a maximum of 0.6 mg/kg or 40 mg daily. It’s not typically used in younger children.

9. Can Acepril Tablet 10 mg be taken with food?

Yes, it can be taken with or without food. Food doesn’t significantly affect absorption, but taking it with a meal may reduce mild stomach upset in some patients.

10. What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember unless it’s nearly time for your next dose. Skip the missed dose if it’s close to the next one, and don’t double up, as this could cause hypotension (low blood pressure).

11. How quickly does Acepril Tablet 10 mg work?

Acepril Tablet 10 mg lowers blood pressure within 1–2 hours, with peak effects in 6–8 hours. Full benefits for hypertension or heart failure may take weeks of consistent use to become evident.

12. What are the common side effects?

Common side effects include:

• Dry cough: Due to increased bradykinin levels.
• Dizziness: From blood pressure reduction.
• Fatigue: Especially when starting treatment.
• Headache: Mild and often temporary.

13. What are the serious side effects?

Serious side effects include:

• Angioedema: Swelling of the face, throat, or limbs (emergency).
• Hypotension: Severe dizziness or fainting.
• High potassium (hyperkalemia): Muscle weakness or irregular heartbeat.
• Kidney impairment: Reduced urine output.

Seek immediate care if these occur.

14. Why does Acepril Tablet 10 mg cause a cough?

The cough is due to elevated bradykinin levels, a byproduct of ACE inhibition. Bradykinin irritates the lungs, causing a dry, persistent cough in 5–20% of users. If severe, a switch to an ARB (e.g., losartan) may be considered.

15. Can Acepril Tablet 10 mg cause allergic reactions?

Yes, though rare, it can cause angioedema or rash, especially in those with prior ACE inhibitor reactions. Stop use and seek help if swelling or breathing issues occur.

16. Who should not take Acepril Tablet 10 mg?

It’s contraindicated for:

• Pregnant women: Risk of fetal harm (second/third trimesters).
• History of angioedema: From ACE inhibitors or hereditary causes.
• Severe kidney artery stenosis: May worsen kidney function.

17. Is Acepril Tablet 10 mg safe during pregnancy?

No, it’s Category D—unsafe in the second and third trimesters due to risks like fetal kidney damage or death. Women planning pregnancy should switch to safer options (e.g., methyldopa).

18. Can I take Acepril Tablet 10 mg while breastfeeding?

It passes into breast milk in trace amounts. While no major harm is reported, alternatives like enalapril may be preferred. Consult a doctor.

19. Does Acepril Tablet 10 mg interact with other medications?

Yes, it interacts with:

• Potassium supplements/diuretics: Risk of hyperkalemia.
• NSAIDs (e.g., ibuprofen): May reduce effectiveness, harm kidneys.
• Lithium: Increases lithium levels, risking toxicity.

List all medications for your doctor.

20. Can I drink alcohol while taking Acepril Tablet 10 mg?

Moderate alcohol is usually safe, but excessive drinking can lower blood pressure too much, causing dizziness. Limit intake and monitor effects.

21. Does Acepril Tablet 10 mg cause weight gain?

No, it doesn’t directly cause weight gain. Fluid retention (edema) is rare but possible in heart failure, which might be mistaken for weight gain.

22. Can Acepril Tablet 10 mg be taken at night?

Yes, it can be taken at night if daytime dizziness is an issue. Consistency in timing is key for steady blood pressure control.

23. How long do I need to take Acepril Tablet 10 mg?

It’s often a lifelong treatment for chronic conditions like hypertension or heart failure. Stopping abruptly can worsen symptoms, so only discontinue under medical advice.

24. Can Acepril Tablet 10 mg be stopped suddenly?

No, stopping suddenly may cause a rebound blood pressure spike or heart failure worsening. Taper off with a doctor’s guidance if needed.

25. Does Acepril Tablet 10 mg affect blood sugar?

It doesn’t directly affect blood sugar but may slightly improve insulin sensitivity in diabetics. Monitor levels as usual.

26. Can Acepril Tablet 10 mg cause high potassium levels?

Yes, by reducing aldosterone, it can increase potassium (hyperkalemia), especially with potassium supplements or certain diuretics. Blood tests monitor this.

27. What should I avoid while taking Acepril Tablet 10 mg?

Avoid:

• Dehydration: Increases hypotension risk.
• High-potassium foods: E.g., bananas, unless monitored.
• NSAIDs: Without doctor approval.

28. Can Acepril Tablet 10 mg cause fatigue?

Yes, fatigue is common, especially early on, as the body adjusts to lower blood pressure. It often improves with time.

29. Is Acepril Tablet 10 mg safe for elderly patients?

Yes, but lower starting doses (e.g., 2.5–5 mg) may be needed due to slower kidney clearance in older adults. Regular monitoring is advised.

30. Does Acepril Tablet 10 mg affect the liver?

Rarely, it may cause mild liver enzyme elevations, but significant liver damage is uncommon unless pre-existing liver issues exist.

31. Can Acepril Tablet 10 mg be used in children?

Yes, for hypertension in children 6+ years, with doses starting at 0.07 mg/kg (up to 5 mg daily), adjusted as needed.

32. What’s the maximum dose of Acepril Tablet 10 mg?

The maximum is 40 mg daily for adults, though up to 80 mg has been used in rare cases under strict supervision.

33. Can Acepril Tablet 10 mg cause dizziness?

Yes, dizziness is common due to lowered blood pressure, especially when standing up quickly. Rise slowly to minimize this.

34. How is Acepril Tablet 10 mg different from other ACE inhibitors?

Acepril Tablet 10 mg is water-soluble and doesn’t require liver activation (unlike enalapril), allowing once-daily dosing and a longer duration of action (half-life ~12 hours).

35. Can Acepril Tablet 10 mg prevent heart attacks?

It doesn’t directly prevent heart attacks but reduces risk by controlling blood pressure and protecting heart and vessels, especially post-heart attack.

36. Does Acepril Tablet 10 mg affect cholesterol?

No, it has no direct effect on cholesterol levels.

37. Can Acepril Tablet 10 mg be taken with diuretics?

Yes, often combined (e.g., with hydrochlorothiazide) for better blood pressure control, but watch for hypotension or hyperkalemia.

38. What tests should I get while on Acepril Tablet 10 mg?

Monitor:

• Blood pressure: For effectiveness.
• Kidney function: Creatinine, eGFR.
• Potassium: To avoid hyperkalemia.

39. Can Acepril Tablet 10 mg cause depression?

No, it’s not linked to depression. Mood changes might relate to underlying conditions.

40. Is Acepril Tablet 10 mg addictive?

No, it’s not addictive or habit-forming.

41. Can Acepril Tablet 10 mg be crushed?

Yes, tablets can be crushed if swallowing is difficult, though a bitter taste may result. Liquid forms exist in some regions.

42. Does Acepril Tablet 10 mg cause hair loss?

Hair loss is very rare and not a well-documented side effect. Other causes should be explored.

43. Can Acepril Tablet 10 mg be used for anxiety?

No, it’s not indicated for anxiety. It treats physical conditions, not mental health issues.

44. What’s the half-life of Acepril Tablet 10 mg?

Its half-life is about 12 hours, supporting once-daily dosing, though effects may last longer due to accumulation.

45. Can Acepril Tablet 10 mg cause a rash?

Yes, a mild rash is possible, and a severe rash may signal angioedema or allergy—seek help if it worsens.

46. Does Acepril Tablet 10 mg affect exercise?

It may cause dizziness during intense exercise, especially if dehydrated. Stay hydrated and start slowly.

47. Can Acepril Tablet 10 mg be taken with aspirin?

Yes, low-dose aspirin (e.g., 81 mg) is safe for heart protection. High doses may reduce Acepril Tablet 10 mg’s effect.

48. Is Acepril Tablet 10 mg expensive?

No, as a generic, it’s affordable, often $4–$10 for a month’s supply in the U.S., depending on dose.

49. Can Acepril Tablet 10 mg cause stomach pain?

Mild stomach upset is possible but uncommon. Taking it with food may help.

50. How should Acepril Tablet 10 mg be stored?

Store at room temperature (15–30°C or 59–86°F), away from moisture and heat, in its original container.