Generic Name Adapalene
Bangla Name এডাপালিন
Available brands 8
Language

Introduction

Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. It is also associated with Cutibacterium acnes (also known as Propionibacterium acnes). Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris. Adapalene has similar efficacy but a superior safety profile compared to tretinoin. Tazarotene is more efficacious than adapalene but is designated as pregnancy category X and hence is contraindicated in pregnant women. Adapalene can also be combined with benzoyl peroxide (BPO), which possesses bactericidal properties, and either adapalene alone, or adapalene BPO combination products, are commonly used to treat mild-to-severe acne.

Uses

Adapalene is a third-generation topical retinoid with anti-comedogenic, comedolytic, and anti-inflammatory properties used to treat acne vulgaris in adolescents and adults.

Adapalene is indicated for the topical treatment of acne vulgaris in patients aged 12 and over.

Associated Conditions

  • Acne Vulgaris

Pharmacodynamics

Adapalene is anticomedogenic, preventing the formation of new comedones and inflammatory lesions, and also acts to reduce inflammation by modulating the innate immune response. Like other retinoid compounds, adapalene is chemically stable but photosensitive; use with sunscreen is recommended. Minor skin irritations, including erythema, scaling, dryness, and stinging/burning, have been reported.

Mechanism of Action

Adapalene is used for the treatment/maintenance of mild-to-severe acne (acne vulgaris). Acne is a multifactorial condition, and evidence exists to support multiple mechanisms of action for adapalene. Adapalene binds to retinoic acid receptor (RAR)-beta and RAR-gamma; this complex subsequently binds to one of three retinoid X receptors (RXRs), which as a complex is capable of binding DNA to modulate transcriptional activity. Although the full extent of transcriptional modulation is not described, retinoid activation is generally known to affect cellular proliferation and differentiation, and adapalene has been shown to inhibit HeLa cell proliferation and human keratinocyte differentiation. These effects primarily account for adapalene's comedolytic and anticomedogenic properties.

In addition, adapalene modulates the immune response by down-regulating toll-like receptor 2 (TLR-2) expression and inhibiting the transcription factor activator protein 1 (AP-1). TLR-2 recognizes Cutibacterium acnes (formerly Propionibacterium acnes), the bacterium primarily associated with acne. TLR-2 activation causes nuclear translocation of AP-1 and downstream pro-inflammatory gene regulation. Therefore, adapalene has a general anti-inflammatory effect, which reduces inflammation-mediated acne symptoms.

When used with benzoyl peroxide, which possesses free radical-mediated bactericidal effects, the combination acts synergistically to reduced comedones and inflammatory lesions.

Absorption

Adapalene is applied topically and absorbed through the skin. In one clinical study treating patients once per day with 2g of 0.3% gel applied to 2 mg/cm2 of skin, 15 patients had detectable blood plasma adapalene levels (0.1 ng/ml) resulting in a mean Cmax of 0.553 ± 0.466 ng/ml and a mean AUC of 8.37 ± 8.46 ng*h/ml on day 10.

Route of Elimination

Adapalene is primarily excreted by the biliary route at about 30 ng/g of the topically applied amount. Approximately 75% of the drug remains unchanged.

Half Life

In one clinical study, after ten days of treatment with 2g of 0.3% cream or gel, the terminal half-life was between 7 and 51 hours, with a mean of 17.2 ± 10.2.

Clearance

Adapalene is rapidly cleared from blood plasma, typically undetectable after 72 hours following topical application.

Toxicity

Toxicity information regarding adapalene is not readily available. Patients experiencing an overdose are at an increased risk of severe adverse effects such as redness, scaling, and skin discomfort. Symptomatic and supportive measures are recommended.

Adapalene has an acute oral LD50 in S-D rats and CD-1 mice of over 5000 mg/kg. The LD50 of 0.3% applied topically to Credo OF1 mice is over 10 ml/kg (30 mg/kg). No systemic or local toxicity was observed in rats treated topically with 6 mg/kg/day of 0.3% adapalene.

Food Interactions

No interactions found.

Dosage

Adapalene 0.1%: It should be applied to the affected areas of skin, once daily at night-time.
Adapalene 0.3%: It should be applied to the entire face and any other affected areas of the skin, once daily in the evening.

Children below 12 years of age: Safety and effectiveness in children below 12 years of age have not been established.

Frequently Asked Questions About Adapalene

1. What is Adapalene?

Adapalene is a topical retinoid medication used primarily to treat acne. It works by affecting the growth of skin cells and reducing inflammation, which helps prevent pores from becoming clogged and forming acne.

2. How does Adapalene work?

Adapalene works by regulating the growth of skin cells. It helps prevent pores from becoming clogged by reducing the formation of comedones (pimples and blackheads) and has anti-inflammatory effects to reduce redness and swelling associated with acne.

3. What is Adapalene used to treat?

Adapalene is primarily used to treat acne vulgaris (common acne). It can help reduce the number and severity of pimples, blackheads, and whiteheads on the face, chest, and back.

4. How do I apply Adapalene?

Adapalene should be applied once daily in the evening to clean, dry skin. Apply a thin layer to the affected areas and avoid contact with the eyes, mouth, and mucous membranes.

5. Can I use Adapalene with other acne treatments?

Adapalene can be used with other acne treatments, but you should consult your doctor to avoid interactions or excessive skin irritation. Some treatments like benzoyl peroxide or other retinoids may cause increased irritation when used together.

6. How long does it take for Adapalene to work?

It typically takes about 4 to 6 weeks of consistent use for Adapalene to show noticeable improvement in acne. Some users may experience an initial worsening of acne before seeing improvements.

7. Can Adapalene be used for sensitive skin?

Adapalene can be used for sensitive skin, but it may cause dryness, redness, or peeling, especially during the first few weeks. Start with a lower strength (0.1%) and gradually increase usage to minimize irritation.

8. What are the common side effects of Adapalene?

Common side effects of Adapalene include:

  • Dryness or peeling of the skin
  • Redness or irritation
  • Burning or stinging sensation
  • Increased sensitivity to sunlight

9. Are there any serious side effects of Adapalene?

Serious side effects are rare but can include severe skin irritation, allergic reactions, or severe dryness. If you experience intense redness, swelling, or blistering, stop using the medication and consult your doctor.

10. Can I use Adapalene while pregnant?

Adapalene is classified as a Category C drug during pregnancy, meaning its safety has not been well established. It should be used during pregnancy only if the benefits outweigh the potential risks. Consult your doctor if you are pregnant or planning to become pregnant.

11. Can Adapalene be used while breastfeeding?

There is limited information about the use of Adapalene during breastfeeding. It is unlikely to pass into breast milk in significant amounts, but you should consult your doctor before using it if you are breastfeeding.

12. How should I store Adapalene?

Store Adapalene at room temperature, away from moisture and heat. Keep the medication in its original packaging and out of the reach of children.

13. Can I use Adapalene if I have eczema or other skin conditions?

If you have eczema or another skin condition, you should consult your doctor before using Adapalene. It may worsen skin irritation in individuals with sensitive skin or certain skin conditions.

14. Can Adapalene cause photosensitivity?

Yes, Adapalene can increase sensitivity to sunlight, making your skin more prone to sunburn. It is important to wear sunscreen and avoid prolonged sun exposure while using Adapalene.

15. How long should I use Adapalene for acne treatment?

The duration of treatment depends on the severity of your acne. Many people use Adapalene for several months, with some continuing treatment to maintain acne control. Follow your healthcare provider’s recommendations for how long to use the medication.

16. Can I use Adapalene if I have rosacea?

Adapalene is not recommended for the treatment of rosacea, as it may worsen the condition. Consult your healthcare provider for appropriate treatment options if you have rosacea.

17. Is Adapalene effective for acne scars?

Adapalene is primarily used to treat active acne. While it may help reduce the appearance of acne scars by promoting skin turnover and reducing new breakouts, it is not a primary treatment for scars. Other treatments, such as laser therapy or chemical peels, may be more effective for scars.

18. Can I use makeup while using Adapalene?

Yes, you can use makeup while using Adapalene, but it’s important to use non-comedogenic (non-pore clogging) makeup. Additionally, avoid heavy makeup that may irritate your skin, especially during the initial stages of treatment.

19. What should I do if I miss a dose of Adapalene?

If you miss a dose of Adapalene, apply it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not apply extra to make up for the missed dose.

20. Can Adapalene be used on the chest and back?

Yes, Adapalene can be used on the chest, back, and other areas where acne is present. However, avoid using it on broken or irritated skin, as this may lead to increased irritation.

21. What should I avoid while using Adapalene?

While using Adapalene, avoid exposure to excessive sun, tanning beds, and harsh skin treatments like chemical peels. It’s also important to avoid using other products that could dry out the skin, such as astringents or alcohol-based toners.

22. Is there a generic version of Adapalene available?

Yes, a generic version of Adapalene, typically marketed under the name Differin, is available. Generic versions are usually more affordable and contain the same active ingredient.

23. What should I do if I experience severe irritation from Adapalene?

If you experience severe irritation, redness, swelling, or blistering, discontinue use and consult your doctor immediately. They may recommend a less potent treatment or other forms of acne management.

24. Can Adapalene be used on sensitive areas such as around the eyes?

Adapalene should not be applied near the eyes, lips, or mucous membranes, as it may cause irritation. Be careful to avoid these areas when applying the medication.

25. Can I use Adapalene with other skincare products?

Be cautious when using Adapalene with other skincare products, particularly those that contain alpha hydroxy acids (AHAs), beta hydroxy acids (BHAs), or other exfoliating ingredients. These can increase irritation when combined with Adapalene. Always consult with your doctor or dermatologist.

26. Can I use Adapalene if I have sensitive skin?

Yes, Adapalene can be used by individuals with sensitive skin, but it may cause dryness, peeling, or irritation, especially in the early stages of treatment. It’s best to start with a lower concentration and gradually increase use as your skin adjusts.

27. Can Adapalene cause peeling?

Peeling is a common side effect of Adapalene. It occurs because the medication promotes the shedding of dead skin cells. This is a normal part of the treatment process, although excessive peeling may indicate irritation.

28. Can I use Adapalene if I have oily skin?

Yes, Adapalene can be beneficial for individuals with oily skin as it helps regulate the turnover of skin cells and prevents clogged pores, which can lead to acne.

29. Can Adapalene be used for other skin conditions like psoriasis?

Adapalene is not typically used to treat psoriasis, as it may cause irritation in individuals with this condition. Consult a healthcare provider for appropriate treatment options for psoriasis.

30. Does Adapalene work for all types of acne?

Adapalene is effective for treating mild to moderate acne, particularly acne vulgaris. It may not be as effective for severe cystic acne, and other treatments, such as oral medications, may be recommended in those cases.

31. How does Adapalene differ from other retinoids?

Adapalene is a third-generation retinoid, and it differs from older retinoids like tretinoin by being less irritating to the skin. It has a more stable chemical structure, making it less likely to degrade when exposed to light and air.

32. Can I use Adapalene in combination with benzoyl peroxide?

Adapalene and benzoyl peroxide can be used together, but they should not be applied at the same time. It is best to use them at different times of the day (e.g., benzoyl peroxide in the morning and Adapalene at night) to reduce irritation.

33. Can I apply Adapalene on broken skin?

No, you should not apply Adapalene on broken, sunburned, or irritated skin, as this may cause additional irritation. Wait until the skin has healed before using the medication.

34. Can I use Adapalene after a chemical peel?

After a chemical peel, your skin may be sensitive and irritated. It’s best to wait until your skin has fully healed before starting Adapalene, as the combination can cause excessive dryness and irritation.

35. Can Adapalene cause an allergic reaction?

Although rare, Adapalene can cause allergic reactions such as swelling, itching, or rash. If you experience these symptoms, stop using the medication and consult your doctor.

36. Can I use Adapalene for acne scars?

Adapalene can help with the prevention of acne scars by treating active acne, but it does not directly reduce the appearance of existing scars. For scar treatment, consider other therapies like laser treatments or chemical peels.

37. How often should I apply Adapalene?

Adapalene is typically applied once daily in the evening. Overuse may lead to excessive dryness and irritation, so it’s important to follow your doctor’s instructions on usage.

38. Can I use Adapalene if I have a sunburn?

It’s not advisable to use Adapalene if you have a sunburn, as it can further irritate the skin. Wait until your skin has healed before resuming use.

39. What should I do if Adapalene makes my skin worse?

It is common for acne to worsen initially when starting Adapalene. However, if the irritation is severe or persists, consult your healthcare provider to discuss alternative treatments.

40. Can I use Adapalene if I have dry skin?

If you have dry skin, Adapalene may cause further dryness and irritation. It’s important to moisturize your skin regularly and start with a lower strength of Adapalene to minimize irritation.

41. Can I use Adapalene if I am taking oral antibiotics for acne?

Yes, you can use Adapalene along with oral antibiotics for acne, but you should consult your healthcare provider to avoid any potential interactions or excessive skin irritation.

42. Can Adapalene be used for acne on the arms or legs?

Adapalene can be used for acne on the arms or legs, but it is most commonly used on the face. Be cautious when applying it to large areas, as this can increase the risk of irritation.

43. Does Adapalene interact with any other medications?

Adapalene may interact with other topical medications that cause skin irritation, such as astringents or other acne treatments. It’s important to inform your doctor about all medications you are using to avoid adverse reactions.

44. What should I do if Adapalene causes excessive dryness?

If Adapalene causes excessive dryness, reduce the frequency of application or use a more gentle moisturizer to help your skin adjust. If dryness persists, consult your doctor.

45. Can I use Adapalene if I have oily skin?

Yes, Adapalene is particularly effective for individuals with oily skin. It helps reduce oil production and prevent clogged pores that lead to acne.

46. Can I apply Adapalene all over my face?

Yes, you can apply Adapalene to the entire face, but avoid areas such as the eyes, mouth, and mucous membranes. Apply it as a thin layer to the affected areas.

47. Can I use Adapalene in conjunction with sunscreen?

Yes, it’s important to use sunscreen while using Adapalene, as it increases skin sensitivity to sunlight. Use a broad-spectrum sunscreen with an SPF of at least 30 to protect your skin.

48. Can I use Adapalene after a facial treatment?

It’s best to wait a few days after a facial treatment before using Adapalene, as your skin may be sensitive. Consult your dermatologist for personalized advice.

49. What should I do if I have a reaction to Adapalene?

If you experience a severe reaction, such as intense redness, swelling, or blistering, stop using the medication and contact your healthcare provider.

50. Can I stop using Adapalene once my acne improves?

To maintain acne control, it’s often recommended to continue using Adapalene, even after your acne improves. However, discuss with your doctor whether it’s appropriate to reduce or discontinue treatment.

Medical review

Last reviewed: 24 Jul 2026

Medically reviewed by:

This is general information, not personal medical advice. Consult a doctor before taking any medicine.

Taking medicines without doctor's advice can cause long-term problems.
Brand medicines containing Adapalene