The Use of Gene Order & Phylogeny to Predict Protein MCQ

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• The most detailed experimental information about protein-protein interactions comes from three-dimensional structures.
  ক

  True

  খ

  False
• Structural analyses on small sets of proteins have shown that the domains from a pair of families bind to each other with the same geometry in multi-domain proteins and in transient interactions.
  ক

  True

  খ

  False
• In the phylogenetic profile method for predicting protein interaction, presence or absence of orthologous genes is scored across a variety of genomes.
  ক

  True

  খ

  False
• In the assessment of methods to predict protein-protein interactions, one third of such pairs were found to physically interact, and an additional third to belong to the same metabolic pathway or functional process.
  ক

  True

  খ

  False
• The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the method) in a set of genomes.
  ক

  True

  খ

  False

  গ

  11. The phylogenetic profile method relies on detection of orthologs (or homologs, in a variation of the metho

  ঘ

  in a set of genomes. a) True b) False
• Due to the requirement for co-regulation as well as colocalization, the method is mostly limited to certain classes of protein-protein interactions.
  ক

  True

  খ

  False
• Domains that are part of a multidomain protein are ______
  ক

  nethier co-regulated nor colocalized

  খ

  not co-regulated but colocalized

  গ

  co-regulated and but not colocalized

  ঘ

  co-regulated and colocalized
• An approach for predicting ______ to look for cases across a set of genomes where _____ are part of the same gene in one genome resulted in gene fusion method.
  ক

  gene interactions, only three to four orthologs

  খ

  gene interactions, two orthologs

  গ

  protein interactions, two or more orthologs

  ঘ

  protein interactions, two orthologs
• Conservation of gene order due to operon structure is _______ so interactions of proteins specific to eukaryotes cannot be detected by method of Conservation of gene order.
  ক

  not applicable to archea genomes

  খ

  not applicable to prokaryote genomes

  গ

  applicable to eukaryote genomes

  ঘ

  not applicable to eukaryote genomes
• In a quantitative assessment of this method (Conservation of gene order) using the genome of the parasitic organism Mycoplasma genitalium as a benchmark.
  ক

  True

  খ

  False
• Members of a stable complex are often co-regulated and thus will be detected by the method of Conservation of gene order.
  ক

  True

  খ

  False
• When comparing pairs of genes or sets of genes in different genomes for this purpose, it is not mandatory for the genes to be orthologs.
  ক

  True

  খ

  False
• Genes that are consistently part of the same operon across different, distantly related genomes are likely to be part of the same protein complex or functional process across all species.
  ক

  True

  খ

  False
• Interactions between proteins can be predicted computationally by looking for sets of genes that occur as a _______
  ক

  single gene in at least one genome

  খ

  multiple genes in at least one genome

  গ

  multiple genes in various genomes

  ঘ

  single gene in various genomes
• Experimentation is most desirable over computational methods by every means.
  ক

  True

  খ

  False