Renal pharmacology MCQ 23+

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• A patient of congestive heart failure having frusemide for long time should be monitored for
  ক

  Hypocalcemia

  খ

  Hypomagnesemia

  গ

  Hyperphosphatemia

  ঘ

  Hypercalcemia

  ঙ

  Hyperkalemia
• Spironolactone is used concomitantly with frusemide for:
  ক

  Preventing potassium depletion

  খ

  Preventing calcium depletion

  গ

  Promoting sodium loss

  ঘ

  Preventing magnesium loss

  ঙ

  Promoting calcium excretion
• Spironolactone
  ক

  Is a K+ sparing diurectic

  খ

  Is more useful in hyperaldosteronism

  গ

  Has a steroid structure

  ঘ

  Can excrete 15-20% filtered sodium

  ঙ

  Acts by blocking the Na+/ Cl- transporter in DCT
• Spironolactone in man
  ক

  Is a weaker diuretic than thiazides

  খ

  Has a slow but prolonged action

  গ

  Is a non-competitive aldosterone antagonist

  ঘ

  Must be given with potassium supplements

  ঙ

  May precipitate diabetes mellitus
• The electrolyte changes followed by prolongedthiazidetherapy include
  ক

  Hyponatraemia

  খ

  Hypercalcemia

  গ

  Hyperkalemia

  ঘ

  Hypermagnesemia

  ঙ

  Hypocalcemia
• Thiazides
  ক

  Are low efficacy diuretics

  খ

  Are associated with hyperuricaemia

  গ

  Inhibit Na+Cl- co-transporter

  ঘ

  Are indicated in nephrogenic diabetes insipidus

  ঙ

  Are effective in acute renal failure
• Side effects of thiazide diuretics include
  ক

  Hyperuricemia

  খ

  Hyperlipidemia

  গ

  Metabolic alkalosis

  ঘ

  Hypocalcemia

  ঙ

  Hypernatremia
• Thiazide
  ক

  Acts on distal convoluted tubule (DC

  খ

  Causes hypercalcaemia

  গ

  Causes hyperuricaemia

  ঘ

  Is a high ceiling diuretic

  ঙ

  Causes hyperkalaemia
• Thiazide diuretics are associated with
  ক

  Hyperuricemia

  খ

  Hyperglycemia

  গ

  Hypercholesterolemia

  ঘ

  Hyperkalemia

  ঙ

  Hypocalcemia
• Potassium sparing diuretics are
  ক

  Spironolactone

  খ

  Triamterene

  গ

  Amiloride

  ঘ

  Frusemide

  ঙ

  Thiazide
• Following agents may cause interstitial nephritis
  ক

  Cyclosporin

  খ

  Non steroidal anti inflammatory agents

  গ

  Erythromycin

  ঘ

  Radio-contrast agent

  ঙ

  Cyclophosphamide
• Drugs causing acute interstitial nephritis are
  ক

  NSAID

  খ

  Cefixime

  গ

  Co-trimoxazole

  ঘ

  Frusemide

  ঙ

  Cyclophosphamide
• Nephrotoxic drugs includes
  ক

  Naproxen

  খ

  Amphotericin B

  গ

  Ranitidine

  ঘ

  Ceftriaxone

  ঙ

  Captopril
• Drug/s causing interstitial nephritis is/are
  ক

  NSAIDs

  খ

  Penicillins

  গ

  Proton pump inhibitors

  ঘ

  Aminoglycosides

  ঙ

  Acyclovir
• Following drugs are nephrotoxic
  ক

  Gentamycin

  খ

  Lithium

  গ

  Metformin

  ঘ

  Cadmium

  ঙ

  Tazobactum- piperacillin
• The diuretics that cause Hypokalaemia and metabolic alkalosis are
  ক

  Frusemide

  খ

  Thiazide

  গ

  Indapamide

  ঘ

  Spironolactone

  ঙ

  Triamterene
• Diuretics which may cause hyponatraemia with hyokalaemia are
  ক

  Hydrochlorthiazide

  খ

  Frusemide

  গ

  Mannitol

  ঘ

  Amiloride

  ঙ

  Spironolactone
• Drug induced hypokalaemia occurs with
  ক

  Caffeine

  খ

  Digitalis

  গ

  Frusemide

  ঘ

  Beta adrenergic antagonist

  ঙ

  Labetalol
• Following drugs are required dose adjustment in severe renal impairment
  ক

  Ciprofloxacin

  খ

  Meropenam

  গ

  Vancomycin

  ঘ

  Linezolid

  ঙ

  Azithromycin