Receptors that Signal through Associated Tyrosine Kinases MCQ

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• What is the process that causes a conformational change in the receptor?
  ক

  Transphosphorylation

  খ

  Trans acetylation

  গ

  Trans methylation

  ঘ

  Trans carboxylation
• What is the basic requirement for the activation of JAK?
  ক

  Receptor oligomerization

  খ

  Ligand oligomerization

  গ

  Enzyme catalyst

  ঘ

  Catalyst oligomerization
• Cite an example for a cytokine receptor that shows preference for a single JAK?
  ক

  GH

  খ

  Interferon-γ

  গ

  IL-2

  ঘ

  IL-9
• Which are the four known Janus family of tyrosine kinases?
  ক

  JAK1, JAK2, JAK3, and TYK2

  খ

  JAK1, JAK2, JAK3, and JAK4

  গ

  JAK1, JAK2, JAK3, and TYK7

  ঘ

  JAK1, JAK2, JAK3, and JAK7
• To which enzymes does the members of the cytokine family of receptors bind to exhibit the enzyme activity?
  ক

  Ligase

  খ

  Janus family of tyrosine kinases

  গ

  Aromatases

  ঘ

  Pectin receptor kinases
• Which group subunit is bound to interleukin 6 in order to show a preference for IL-6?
  ক

  Gp130

  খ

  Gp180

  গ

  Gp751

  ঘ

  Gp190
• What happens when the gp130 subunit and the leukemia inhibitory factor receptor β-subunit is combined with a ciliary neurotrophic factor’s receptor subunit?
  ক

  Changes the conformation of ciliary neurotrophic factor

  খ

  Activates ciliary neurotrophic factor

  গ

  Deactivates ciliary neurotrophic factor

  ঘ

  A preference for ciliary neurotrophic factor developed
• In order to serve as a molecular interface between the neuroimmune and endocrine systems, which group subunit binds to the leukemia inhibitory factor?
  ক

  Gp130

  খ

  Alpha Regulatory

  গ

  Beta Regulatory

  ঘ

  Gp77
• What disease is caused by the autosomal recessive mutations of the leptin receptor?
  ক

  Laron dwarfism

  খ

  Morbid obesity

  গ

  Phenylketonuria

  ঘ

  Maple Syrup Urine disease
• In extracellular and cytoplasmic domains, members of the cytokine family of receptors share homology.
  ক

  True

  খ

  False
• Members of the cytokine family of receptors resemble receptor tyrosine kinases in their mechanism of action.
  ক

  True

  খ

  False
• What is the name of the disease that is caused by autosomal recessive mutations of the GH receptor?
  ক

  Morbid obesity

  খ

  Phenylketonuria

  গ

  Laron dwarfism

  ঘ

  Maple Syrup Urine disease
• Which among the following ligands regulate hematopoiesis or the immune response?
  ক

  GH

  খ

  Erythropoietin

  গ

  Prolactin

  ঘ

  Leptin
• Which are the three hormones that act as ligands in the receptor cytokine family?
  ক

  GH, Prolactin and Leptin

  খ

  FSH, Prolactin and Leptin

  গ

  GH, Adrenaline and Leptin

  ঘ

  GH, LH and FSH