Molecular Biology And Genetics MCQ

Test your knowledge with important Molecular Biology And Genetics MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30 + more Molecular Biology And Genetics MCQs at Bissoy

Some of the genes from viruses introduced into plants in fully functional form often exhibit Mendelian inheritance because

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The genes are stably integrated in chromosomes

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The genes are stably maintained in vectors

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The genes are co-expressed with chromosomal genes

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The genes are not interrupted by introns
Which one of the following modifications is common to both protein and DNA?

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SUMOylation

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Nitrosylation

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Methylation

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Ubiquitination
The 4-amino or 4-keto group of pyrimidine bases is located in the

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Major groove of the double stranded DNA

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Minor groove of the double stranded DNA

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Minor groove of the B form DNA but not the A form DNA

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Major groove of the B form DNA but not the A form DNA
Efficient expression of a heterologous protein product is influenced by

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Transcriptional efficiency

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Copy number of the plasmid

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Codon bias

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All of the above
The G + C content of bacteriophage M13 double stranded DNA is 68%. What would you expect the G + C content of its mRNA?

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About 68%

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About 34%

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About 32%

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About 86%
How many different protein sequences of 100 residues can be generated using 20 standard amino acids?

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10020

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100 × 20

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20100

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100! × 20!
Nuclease-hypersensitive sites in the chromosomes are sites that appear to be

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H2 and H4 histone free

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H1 and H2 histone free

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H3 and H4 histone free

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Nucleosome free
The 5' ends of the mature forms of the prokaryotic mRNAs and tRNAs are

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A triphosphate group in mRNAs and a monophosphate group in tRNAs

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Triphosphate groups in both mRNAs and tRNAs

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Monophosphate groups in both mRNAs and tRNAs

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A monophosphate group in mRNAs and a triphosphate group in tRNAs
During transcription,

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DNA gyrase introduces negative supercoils and DNA topoisomerase I removes negative supercoils

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DNA topoisomerase I introduces negative supercoils and DNA gyrase removes negative supercoils

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Both DNA gyrase and DNA topoisomearse I introduce negative supercoils

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Both DNA gyrase and DNA topoisomearse I remove negative supercoils
Which of the following statements are true with respect to a special complex called 'dicer'? P. It consists of deoxyribonuclease and DNA fragments. Q. It consists of ribonuclease and RNA fragments. R. It is involved in gene silencing. S. It triggers apoptosis.

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P, R

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Q, R

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P, S

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Q, S
Caspases are involved in the process of

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DNA replication

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Mutation and recombination

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Antibody synthesis

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Apoptosis
The enzyme that transcribes the eukaryotic genes encoding precursor ribosomal RNAs (pre-rRNAs) of 28S, 18S and 5.8S rRNAs is

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RNA polymerase I

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RNA polymerase II

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RNA polymerase III

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RNA polymerase IV
Which one of the following is not a therapeutic agent based on nucleic acid for the treatment of genetic disorders?

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Antisense oligonucleotide

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Ribozyme

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Aptamer

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Avidin
Molecular chaperones are class of proteins that facilitate

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The proper folding of newly synthesized proteins

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Unfolding of newly synthesized proteins

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Degradation of newly synthesized proteins

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Targeting of newly synthesized proteins
How many 3-tuples are possible for the following amino acid sequence?

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4

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5

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11

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12
Diploid Drosophila has eight chromosomes. Which one of the following terms should not be used to describe Drosophila with sixteen numbers of chromosomes?

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Polyploid

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Aneuploid

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Euploid

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Tetraploid
A truncated polypeptide is synthesized due to a nonsense mutation. Where would you introduce another mutation to obtain a full-length polypeptide?

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Ribosomal protein gene

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Transfer RNA gene

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DNA repair gene

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Ribosomal RNA gene
PKU is one of the best-known hereditary disorders in amino acid metabolism. The defect is attributed to a lesion in one of the following enzymatic activities:

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Phenylalanine ammonia lyase

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Phenylalanine hydroxylase

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Tyrosine hydroxylase

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Phenylalanine transaminase
Topological winding number of a 2.0 kb covalently closed circular DNA was found to be 191 with a writhing number of -4. Hence, its linking number and the number of base pair per turn when the molecule is laid flat on the surface is . . . . . . . . and . . . . . . . ., respectively.

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187, 10.69

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195, 10.25

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200, 10.00

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187, 10.50
Match the entries in Group I with the entries in Group II. 

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<table class="table-style-1"> <tr> <td>Group I</td> <td>Group II</td> </tr> <tr> <td>P. RNAse P</td> <td>1. Polyadenylation</td> </tr> <tr> <td>Q. RNase H</td> <td>2. Splicing</td> </tr> <tr> <td>R. snRNAs</td> <td>3. Ribozymes</td> </tr> <tr> <td>S. CstF</td> <td>4. DNA-RNA hybrids</td> </tr></table> P-3, Q-4, R-2, S-1

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P-4, Q-3, R-2, S-1

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P-3, Q-2, R-1, S-4

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P-2, Q-4, R-1, S-3
A mutation in a gene that codes for a polypeptide results in a variant polypeptide that lacks the last three amino acids. What type of mutation is this?

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Synonymous mutation

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Nonsense mutation

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Missense mutation

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Silent mutation
Ames test is used to determine

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The mutagenicity of a chemical

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Carcinogenicity of a chemical

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Both mutagenicity and carcinogenicity of a chemical

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Toxicity of a chemical
Of the two diploid species, species I has 36 chromosomes and species II has 28 chromosomes. How many chromosomes would be found in an allotriploid individual?

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42 or 54

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46 or 50

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74 or 86

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84 or 108
Which of the following statements with respect to the orientation of the nitrogenous bases to the pentose sugars, and the puckering of the sugar, is correct?

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Anti, and 2'-endo in A form DNA

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Anti, and 2'-endo in B form DNA

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Syn, and 3'-endo in A form DNA

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Syn, and 3'-endo in B form DNA
If a segment of a sense strand of DNA is 5'-ATGGACCAGA-3', then the resulting RNA sequence after transcription is

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5'-AGACCAGGTA-3'

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5'-UCUGGUCCAU-3'

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5'-UACCUGGUCU-3'

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5'-AUGGACCAGA-3'
Which of the following processes can increase genetic diversity of bacteria in nature? P. Conjugation Q. Transformation R. Transduction S. Transfection

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P only

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P and Q only

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P, Q and R only

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P, Q, R and S
Synteny refers to

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Gene duplication from a common ancestor

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A tree representation of related sequences

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The extent of similarity between two sequences

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Local conservation of gene order
An example for template independent DNA polymerase is

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DNA Polymerase I

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RNA polymerase

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Terminal deoxynucleotidyl transferase

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DNA polymerase III
The major groove of DNA is lined by

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N3 of purine and N1 of pyrimidine

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N7 of purine and O2 of pyrimidine

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N7 of purine and C4 of pyrimidine

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None of the above
In a genetic cross between the genotypes WWXX and wwxx, the following phenotypic distributions were observed among the F2 progeny: WX, 562; wx, 158; Wx, 38; and wX, 42. Likewise, a cross between XXYY and xxyy yielded the following results: XY, 675; xy, 175; Xy, 72; and xY, 78. Similarly, a cross between WWYY and wwyy yielded: WY, 292; wy, 88; Wy, 12; and wY, 8. In all the genotypes, capital letters denote the dominant allele. Assume that the F1 progeny were self-fertilized in all three crosses. Also, double cross-over does not occur in this species. Which of the following is correct?

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Relative position: W-X-Y Distances: W-X = 5 map units, X-Y = 17 map units

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Relative position: X-Y-W Distances: X-Y = 15 map units, Y-W = 11 map units

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Relative position: Y-W-X Distances: Y-W = 5 map units, W-X = 11 map units

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Relative position: X-W-Y Distances: X-W = 5 map units, W-Y = 10 map units