Methods for Enhancement MCQ

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• Which of the following is used in molecular encapsulation of drugs for enhancing bioavailability?
  ক

  Highly water-soluble compound

  খ

  Cyclodextrin

  গ

  Inorganic clays like bentonite

  ঘ

  Creating metastable polymorphs
• In the below picture which form of solid solution of griseofulvin with succinic acid is shown?
  ক

  Solid solution

  খ

  Eutectic mixture

  গ

  Micronized drug

  ঘ

  Coarse drug
• Which of the following is used in solid solutions method of enhancing bioavailability?
  ক

  Highly water-soluble compound

  খ

  Organic solvent

  গ

  Inorganic clays like bentonite

  ঘ

  Creating metastable polymorphs
• Which of the following is used in the solvent deposition method of enhancing bioavailability?
  ক

  Freeze drying

  খ

  Organic solvent

  গ

  Inorganic clays like bentonite

  ঘ

  Creating metastable polymorphs
• Which one of the following is used for selective adsorption on insoluble carriers of the drugs?
  ক

  Freeze drying

  খ

  Organic solvent

  গ

  Inorganic clays like bentonite

  ঘ

  Creating metastable polymorphs
• How pH alteration of the drug microenvironment is done?
  ক

  Altering the pH while the administration

  খ

  In situ salt formation

  গ

  Altering the pH of the tissue

  ঘ

  Formulating the drug in such a way that it gets activated only when it reaches the tissue pH
• Salts improve solubility and dissolution characteristics.
  ক

  True

  খ

  False
• What is the principle behind the use of surfactants?
  ক

  Reducing the size of solid drug particles

  খ

  Enhancing the dissolution rate by promoting wetting

  গ

  Improving solubility

  ঘ

  Alter the pH of the microenvironment
• What will be the particle size after micronization of drugs?
  ক

  1-10 micron

  খ

  10-20 micron

  গ

  20-30 micron

  ঘ

  1-5 micron
• Which of the following is not an approach for overcoming bioavailability problems?
  ক

  Pharmaceutic approach

  খ

  Pharmacokinetic approach

  গ

  Biologic approach

  ঘ

  Partition coefficient approach
• A drug with poor stability means higher bioavailability.
  ক

  True

  খ

  False
• Poor bioavailability means poor aqueous solubility.
  ক

  True

  খ

  False