Major histocompatibility complex & transplantation MCQ 14+

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• Regarding HLA class-I antigen
  ক

  They are expressed on all nucleated cells

  খ

  They are made up of heavy and light chain

  গ

  They are essential for viral antigen detection by cytotoxic T Cell

  ঘ

  CD8+cell recognize the antigen through HLA

  ঙ

  T-helper cell recognize antigen in association with HLA class-I
• The major histocompatibility complex MHC in man
  ক

  Is situated on chromosome 6

  খ

  Is involved in antigen presentation

  গ

  The genes are grouped into two types class I and class II

  ঘ

  Has positive association with renal failure

  ঙ

  Is tested on a serum sample
• Diseases associated with HLA are
  ক

  Insulin dependent diabetes

  খ

  Ankylosing spondylitis

  গ

  Familial polyposis coli

  ঘ

  Cushing disease

  ঙ

  Tuberculosis
• Class II MHC protein
  ক

  Have high degree of polymorphism

  খ

  Involved in the presentation of antigen by macrophage

  গ

  Have binding sites for CD4 proteins

  ঘ

  Found on the surface of both T cell and B cells

  ঙ

  Composed of one polypeptide chain
• MHC class I molecules
  ক

  Are highly polymorphic

  খ

  Associated with β2-microglobulin

  গ

  Are only expressed on professional antigen presenting cells

  ঘ

  Associated preferentially with pathogen derived peptides

  ঙ

  Accommodate peptides in an open-ended peptide binding groove
• Regarding MHC molecules
  ক

  They are cell surface glycoproteins

  খ

  Play critical role in self and non-self-recognition

  গ

  MHC genes are located on short arm of chromosome 6

  ঘ

  MHC I molecules present only on antigen presenting cells surface

  ঙ

  Highest level of MHC molecules are expressed on hepatocytes
• HLA allele B27 is associated with following inflammatory diseases
  ক

  Ankylosing spondylitis

  খ

  Post gonococcal arthritis

  গ

  Acute anterior uveitis

  ঘ

  Rheumatoid arthritis

  ঙ

  Chronic active hepatitis
• HLA matching is not required in transplant of
  ক

  Cornea

  খ

  Bone

  গ

  Liver

  ঘ

  Kidney

  ঙ

  Bone marrow
• HLA matching is required in following organ transplantation
  ক

  Kidney

  খ

  Bone marrow

  গ

  Cornea

  ঘ

  Bone

  ঙ

  Liver
• MHC restriction is experienced by
  ক

  Helper T lymphocytes

  খ

  B-Lymphocytes

  গ

  Macrophages

  ঘ

  Lymphokine activated killer cell(LA

  ঙ

  NK cell
• MHC class II molecules are expressed on
  ক

  Dendritic cell

  খ

  Macrophage

  গ

  Fibroblast

  ঘ

  Platelet

  ঙ

  Red blood cell
• Human leukocyte antigens are
  ক

  Encoded by MHC gene

  খ

  Present on the cell surface of almost all nucleated cell

  গ

  Play a critical role in antigen presentation

  ঘ

  Intracellular glycoprotein

  ঙ

  Play major role in causing infection
• Methods of CD4-positive cells counting in HIV infected patients are
  ক

  Flow cytometry

  খ

  Microchip CD4 counting methods

  গ

  Immunoelectrophoresis

  ঘ

  Agglutination test

  ঙ

  ELISA
• Class II HLA antigens
  ক

  Are involved in the initiation of immune responses

  খ

  Reside on human chromosome 6

  গ

  Are expressed on the surface of all nucleated cells

  ঘ

  Are coded by alleles found at loci labeled A

  ঙ

  B and C

  চ

  Enable cytotoxic T-lymphocytes to eliminate virus infected cells