Localized Alignments in Sequences MCQ

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• Although MOTIF program is used successfully for making the BLOCKS database, it is limited in the pattern sizes that can be found.
  ক

  True

  খ

  False
• The pattern searching method type of analysis was performed on groups of related proteins, and the amino acid patterns that were located may be found in the Prosite catalog.
  ক

  True

  খ

  False
• Which of the following is not true regarding the BLOCKS?
  ক

  Blocks of width 10–55 are extracted from a protein MSA

  খ

  The protein MSA is up to 400 sequences

  গ

  The program doesn’t accept manually reformatted MSAs

  ঘ

  The program accepts FASTA format
• In the method of extraction of blocks from a global or local MSA, a global MSA of related protein sequences usually includes regions that have been aligned without gaps in any of the sequences.
  ক

  True

  খ

  False
• Block analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
  ক

  True

  খ

  False
• Which of the following is untrue regarding the block analysis method?
  ক

  Blocks represent a conserved region in the MSA

  খ

  Blocks differ from profiles in lacking insert and delete positions in the sequences

  গ

  Every column includes only matches and mismatches

  ঘ

  Blocks may be made by searching for a section of an MSA alignment that is low conserved
• The program Profilemake can be used to produce a profile from an MSA.
  ক

  True

  খ

  False
• Profiles are found by performing the _____ MSA of a group of sequences and then removing the _______ regions in the alignment into a smaller MSA.
  ক

  local, more highly conserved

  খ

  global, low conserved

  গ

  global, more highly conserved

  ঘ

  local, low conserved