Introns are Removed from RNA by Splicing MCQ

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• Self-splicing is achieved by the formation of specific structures within the introns.
  ক

  True

  খ

  False
• Which of the following groups can perform self splicing?
  ক

  mRNA, rRNA

  খ

  rRNA, mtRNA

  গ

  tRNA, mRNA

  ঘ

  rRNA, tRNA
• The branch point site conserved sequence for group II intron is ___________
  ক

  A

  খ

  T

  গ

  G

  ঘ

  C
• Group II introns are spliced by the splicosome complex.
  ক

  True

  খ

  False
• Formation of the active site only in the C complex is a necessity for avoiding wrong splicing.
  ক

  True

  খ

  False
• Which of the following complexes produces the active site of the splicosome?
  ক

  A complex

  খ

  A complex rearrangement

  গ

  B complex

  ঘ

  C complex
• Which of the following pairs is held together by the complementary base pairing in the B complex of splicosome?
  ক

  U1, U2

  খ

  U2, U4

  গ

  U4, U6

  ঘ

  U2, U5
• Which three snRNPs together make the tri-snRNP particle?
  ক

  U1, U2, U4

  খ

  U2, U4, U5

  গ

  U1, U5, U6

  ঘ

  U4, U5, U6
• The binding of U2 snRNP is aided by BBP and thus promotes 5’ site splicing.
  ক

  True

  খ

  False
• Which of the following is not involved in creating the early splicosome complex?
  ক

  Base pairing of U1 and splice site

  খ

  U2AF binding to 3’ splicing site

  গ

  U2 binding to branch point site

  ঘ

  BBP interaction with U2AF
• Which of the following proteins is correctly paired to its function?
  ক

  U2AF – binds to branch point site

  খ

  DEAD-box – recognizes pyrimidine tract

  গ

  RNA annealing factor – loading snRNPs onto mRNA

  ঘ

  BBP – dissociation of RNA–RNA interactions
• Which of the following component of splicosome recognizes the 3’ splice site?
  ক

  U2

  খ

  U2AF

  গ

  BBP

  ঘ

  U4
• Which of the following splicosomal RNAs does not take part in the 5’ site splicing of the intron?
  ক

  U1

  খ

  U2

  গ

  U5

  ঘ

  U6
• 5’ splice site is recognized by which of the following type of RNA present in the splicosome?
  ক

  U2

  খ

  U4

  গ

  U5

  ঘ

  U6
• Which of the following is not a function of snRNPs?
  ক

  5’ splice site reorganization

  খ

  3’ splice site reorganization

  গ

  Branch point site

  ঘ

  Catalyze 5’ splice site cleavage
• “snurps” are made of ____________
  ক

  RNA

  খ

  Protein

  গ

  DNA and protein

  ঘ

  RNA and protein
• Splicosome is a proteinaceous enzyme.
  ক

  True

  খ

  False
• Splicosome comprises of ______________
  ক

  Only proteins

  খ

  Only RNA

  গ

  RNA and protein

  ঘ

  RNA and lipoprotein
• What does the diagram denote?
  ক

  Splicing

  খ

  Alternative splicing

  গ

  Trans-splicing

  ঘ

  Exon shuffling
• In trans-splicing the excised intron forms a lariat structure.
  ক

  True

  খ

  False
• The transesterification reaction is ATP independent.
  ক

  True

  খ

  False
• The second transesterification reaction occurs between __________
  ক

  The 3’ splicing site of intron and 5’ splice site of intron

  খ

  The 3’ splicing site of intron and the branch point site

  গ

  The 5’ splicing site of intron and 3’ end of exon

  ঘ

  The 5’ end of exon and the 3’ splice site
• The first transesterification reaction between the branch point site and the 5’ splice site is a __________ reaction.
  ক

  SN1

  খ

  SN2

  গ

  E1

  ঘ

  E2
• To achieve splicing of an intron how many phosphodiester bonds are formed __________
  ক

  1

  খ

  2

  গ

  3

  ঘ

  0
• How many consensus sequences for splicing are found in an exon?
  ক

  1

  খ

  2

  গ

  3

  ঘ

  0
• The highly conserved base at the branch point site is __________
  ক

  A

  খ

  U

  গ

  G

  ঘ

  C
• The 3’ end of an intron is marked by __________
  ক

  Donor site

  খ

  Acceptor site

  গ

  AT rich site

  ঘ

  Branch point site
• During splicing which of the following sites is not recognized by the splicosome?
  ক

  Donor

  খ

  Branch point

  গ

  Acceptor

  ঘ

  G-rich site
• The splice site is found in __________
  ক

  3’ end of exon

  খ

  5’ end of intron

  গ

  Within the exon

  ঘ

  Within the intron