Inflammation MCQ 66+

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• Cell types found in an established granuloma include
  ক

  Histiocytes

  খ

  Epithelioid cells

  গ

  Neutrophils

  ঘ

  Activated T lymphocytes

  ঙ

  Langerhans giant cells
• Granulomatous inflammation is seen in the following features
  ক

  Talc in the wound

  খ

  Deep mycoses

  গ

  2nd stage of syphilis

  ঘ

  Infection with gonococcus

  ঙ

  Seminoma of testis
• Examples of diseases with granulomatous inflammation are
  ক

  Sarcoidosis

  খ

  Crohn disease

  গ

  Cat scratch disease

  ঘ

  Ochronosis

  ঙ

  Parkinson disease
• A non caseating granuloma
  ক

  Can be seen in tuberculoid leprosy

  খ

  Is found in foreign body reaction

  গ

  Is not a feature of tuberculosis

  ঘ

  Is always found in Sarcoidosis

  ঙ

  Is a typical feature of Syphilis
• Langhans giant cells
  ক

  Have a peripheral ring of nuclei with central clearing

  খ

  Are characteristically seen in tuberculosis

  গ

  Are derived from macrophages

  ঘ

  Are the antigen presenting cells in the skin

  ঙ

  Have nuclei scattered randomly throughout the cytoplasm
• The following organisms characteristically induce a granulomatous inflammatory response
  ক

  Mycobacterium tuberculosis

  খ

  Treponema pallidum

  গ

  Mycobacterium leprae

  ঘ

  Staphylococcus aureus

  ঙ

  Streptococcus pneumoniae
• Granulomatous inflammation
  ক

  Contains epithelioid cells derived from tissue histiocytes

  খ

  Occurs in sarcoidosis

  গ

  Occurs in visceral leishmaniasis

  ঘ

  Is a type III hypersensitivity response

  ঙ

  Shows dominant infiltration of tissue by plasma cells
• Granulomatous diseases are
  ক

  Pneumoconiosis

  খ

  Aspergillosis

  গ

  Sarcoidosis

  ঘ

  Cat scratch disease

  ঙ

  Candidiasis
• Granulomas are composed of
  ক

  Epithelioid cells

  খ

  Lymphocytes

  গ

  Langhans' type of giant cells

  ঘ

  Newly formed blood vessels

  ঙ

  Granulation tissue
• Granuloma are found in
  ক

  Leprosy

  খ

  Syphilis

  গ

  Brucellosis

  ঘ

  Cryptococcosis

  ঙ

  Rickettsia
• Epitheloid cell granuloma is found in
  ক

  Syphilis

  খ

  Sarcoidosis

  গ

  Toxoplasmosis

  ঘ

  Rhinosporodiosis

  ঙ

  Amyloidosis
• Granuloma formation is/are frequently associated with
  ক

  Angiogenesis

  খ

  Persistent irritants

  গ

  Healing process

  ঘ

  Acute inflammation

  ঙ

  Wound contracture
• Collection of epithelioid cells in tissue
  ক

  May be in response to foreign body

  খ

  Is a diagnostic clue for sarcoidosis

  গ

  Is a common finding in non-specific inflammations

  ঘ

  Without caseation necrosis is never tuberculosis

  ঙ

  May be seen in seminoma
• Granuloma is found around
  ক

  Foreign body

  খ

  Keratin

  গ

  Necrotic tissue

  ঘ

  Indigestible particle

  ঙ

  Extravaseted RBC
• Granuloma may occur at following conditions
  ক

  Crohn’s disease

  খ

  Sarcoidosis

  গ

  Cat scratch disease

  ঘ

  Syphilis

  ঙ

  Ulcerative colitis
• Granulomatous inflammatory disease
  ক

  Cat scratch disease

  খ

  Tuberculosis

  গ

  Sarcoidosis

  ঘ

  Chronic tonsillitis

  ঙ

  Chronic otitis media
• In chronic granulomatous reaction
  ক

  Macrophages collect cytoplasm to convert into epithelioid cells

  খ

  Fibroblasts fuse to form multinucleated giant cells

  গ

  Signs of destruction of attempts of repair are present simultaneously

  ঘ

  Caseous material is pathognomonic of tuberculosis

  ঙ

  Neutrophils are arranged at the peripheral region
• Tissue damage in chronic inflammation is caused by
  ক

  The macrophages

  খ

  O2 derived free radicals

  গ

  Offending agents

  ঘ

  Metalloproteinases

  ঙ

  Prostaglandins
• Chronic inflammation is characterized by
  ক

  Tissue destruction

  খ

  Angiogenesis

  গ

  Fibrosis

  ঘ

  Increased tissue concentration of lymphocytes

  ঙ

  Infiltration with neutrophils
• After phagocytosis microorganisms are killed by
  ক

  Hydrogen peroxide

  খ

  Lysozyme

  গ

  Myelo peroxidase alone

  ঘ

  Complement system

  ঙ

  Immunoglobulins
• Morphologic features of chronic inflammation are
  ক

  Infiltration with macrophages

  খ

  Fibrosis

  গ

  Plasma cell infiltration

  ঘ

  Presence of exudates

  ঙ

  Infiltration with neutrophils
• Phagocytosis results in release of
  ক

  Lysosomal products

  খ

  Hydrogen peroxide

  গ

  Arachidonic acid metabolites

  ঘ

  TGF-f3

  ঙ

  Interleukin
• Suppurative inflammation
  ক

  Is seen in staphylococcal infection

  খ

  Contains polymorphs

  গ

  Usually heals by secondary intention

  ঘ

  Is a consequence of infarction

  ঙ

  Is the early stage of gangrene
• Features of chronic inflammation are
  ক

  Tissue destruction

  খ

  Fibrosis

  গ

  Exudate

  ঘ

  Edema

  ঙ

  Suppuration
• Acute phase reaction includes
  ক

  Fever

  খ

  Increased sleep

  গ

  Increased ESR

  ঘ

  Increased appetite

  ঙ

  Decreased CRP
• Acute phase reaction include
  ক

  Increased sleep

  খ

  Increased ESR

  গ

  Fever

  ঘ

  Decreased CRP (c reactive protei

  ঙ

  Increased appetite
• Features of systemic inflammatory response syndrome are
  ক

  Temperature>38.00 C

  খ

  Respiratory rate >20/min

  গ

  Heart rate >90/minutes

  ঘ

  White cell count >12x109/l

  ঙ

  Blood glucose < 3 mmol/l
• Acute phase proteins are
  ক

  Fibrinogen

  খ

  Heptoglobin

  গ

  Prothrombin

  ঘ

  Serum amyloid protein

  ঙ

  Haemoglobin
• ESR is raised in
  ক

  Tuberculosis

  খ

  Multiple myeloma

  গ

  Anemia of chronic disorder

  ঘ

  Polycythemia

  ঙ

  Congestive heart disease
• CRP is useful marker to indicate active disease in
  ক

  Rheumatoid arthritis

  খ

  Ankylosing spondylosis

  গ

  Reactive arthritis

  ঘ

  SLE

  ঙ

  Systemic sclerosis