Immunoglobulin Gene Structure and their Multigene Organization MCQ

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• What is the region that is present between the CDRs in the variable region of a heavy chain in an immunoglobulin called?
  ক

  Framework region

  খ

  CDR region

  গ

  Hinge region

  ঘ

  Bent region
• What are the regions that are responsible for diversity in an immunoglobulin called?
  ক

  Framework region

  খ

  CDR region

  গ

  Hinge region

  ঘ

  Bent region
• What is the other type of region that is present in the constant gene region of the heavy chain of an immunoglobulin?
  ক

  Framework region

  খ

  CDR region

  গ

  Hinge region

  ঘ

  Bent region
• What happens to the diversity of antibodies/immunoglobulins with the insertion of D segment in heavy chain?
  ক

  Increases

  খ

  Decreases

  গ

  Remains constant

  ঘ

  Diversity is independent of D segment
• Where does the variable region rearrangements of an immunoglobulin take place?
  ক

  Thymus

  খ

  Bone marrow

  গ

  Spleen

  ঘ

  Lymphatic tissue
• Heavy chain of an immunoglobulin also has three gene segments.
  ক

  Yes

  খ

  No
• A functional variable region gene of a light chain contains two coding gene segments that are separated by a non-coding DNA sequence in germ-line DNA.
  ক

  True

  খ

  False
• What are the types of light chain that are developed in an immunoglobulin?
  ক

  Either a kappa or a lambda

  খ

  Either a kappa or a gamma

  গ

  Either a gamma or a lambda

  ঘ

  Either a gamma or a delta
• The light chain development of an immunoglobulin takes place at the time of _______ processing.
  ক

  DNA

  খ

  mRNA

  গ

  tRNA

  ঘ

  rRNA
• The variable region of a light chain in an immunoglobulin is encoded by the _________
  ক

  Segment V

  খ

  Segment J

  গ

  Segment C

  ঘ

  Segments VJ
• The gene segments in an immunoglobulin are separated by non-coding genes.
  ক

  True

  খ

  False
• What are the multigene families that are present in a heavy chain or a light chain of an immunoglobulin called?
  ক

  Gene segments

  খ

  Gene coders

  গ

  Gene clusters

  ঘ

  Gene fragments
• When does the organization of the genes in an immunoglobulin take place?
  ক

  During the development and differentiation of T cells

  খ

  During the development and differentiation of B cells

  গ

  During the development and differentiation of both B cells and T cells

  ঘ

  During the development and differentiation of neither B cells nor T cells
• The heavy chains and light chains in an immunoglobulin are held together by ________ bonds.
  ক

  Covalent

  খ

  Disulphide

  গ

  Hydrogen

  ঘ

  Ionic
• What are the chains of an immunoglobulin comprises of?
  ক

  One heavy chain and one light chain

  খ

  Two heavy chains and two light chains

  গ

  One heavy chain and two light chains

  ঘ

  Two heavy chains and one light chain