Graft rejection MCQ 5+

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• The following grafts are rejected
  ক

  Allo graft

  খ

  Xeno graft

  গ

  Autograft

  ঘ

  Iso graft

  ঙ

  Corneal graft
• In acute rejection of solid organ transplant graft damage is
  ক

  Caused by recognition of donor peptides by cytotoxic T cell

  খ

  Caused by helper T cells

  গ

  Due to preformed antibody

  ঘ

  Caused by release of macrophage cytokines such as IL-1 & TNF-

  ঙ

  Caused by transplant atherosclerosis
• Hyperacute rejection of grafts
  ক

  May be minimized by matching blood group

  খ

  Mediated by preformed antibodies

  গ

  Occurs within 2-4 days of transplantation

  ঘ

  Associated with T-cell mediated reaction

  ঙ

  Occurs in autograft
• Causes of acute graft rejection are
  ক

  Antibody mediated

  খ

  Cell mediated

  গ

  T-cell dependent

  ঘ

  Irreversible

  ঙ

  Seen after first six months
• During post-transplant period, the prospect of graft acceptance can be improved by
  ক

  Irradiated blood

  খ

  Leukocyte depleted red blood cells

  গ

  Intramuscular GM -CSF infusion

  ঘ

  Random donor HLA identical blood

  ঙ

  Previous blood transfusion