Genetics MCQ 78+

Test your knowledge with important Genetics MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 108 + more Genetics MCQs at Bissoy

• p53 is capable of binding to which family of proteins?
  ক

  Bcl-1

  খ

  Bcl-2

  গ

  Bcl-3

  ঘ

  Bcl-4
• p53 is a _________
  ক

  translation factor

  খ

  polymerase

  গ

  endonuclease

  ঘ

  transcription factor
• For the development of cancer, which of the following is the most influential component of the genome?
  ক

  EGF

  খ

  Cytochrome c

  গ

  TP53

  ঘ

  T53
• When was the genetic basis of retinoblastoma first explained?
  ক

  1961

  খ

  1971

  গ

  1981

  ঘ

  1991
• The first tumor-suppressor gene to be studied is associated with ______________________
  ক

  myeloma

  খ

  sarcoma

  গ

  retinoblastoma

  ঘ

  carcinoma
• The oncogenes act __________________
  ক

  dominantly

  খ

  recessively

  গ

  occasionally

  ঘ

  frequently
• Proto-oncogenes are possessed by the ______________________
  ক

  RNA virus

  খ

  DNA virus

  গ

  Cells themselves

  ঘ

  Pathogenic bacteria
• Oncogenes promote the growth of cancer cells.
  ক

  True

  খ

  False
• Which of the following is a test for detecting precancerous cells?
  ক

  MRI

  খ

  CT Scan

  গ

  Pap smear

  ঘ

  Endoscopy
• The expression of telomerase on cancer cells can be considered an epigenetic change.
  ক

  True

  খ

  False
• Leukemias usually arise from _________
  ক

  epithelial cells

  খ

  neurons

  গ

  blood-forming tissues

  ঘ

  epidermal cells
• The most common solid tumors – breast, colon etc. arise in _____________ cells.
  ক

  epithelial

  খ

  mesothelial

  গ

  nerve cells

  ঘ

  muscle cells
• Cancer is monoclonal.
  ক

  True

  খ

  False
• The screening tests for fetal chromosomal anomalies are
  ক

  Amniocentesis

  খ

  Chorionic villus sampling

  গ

  Nuchal translucency

  ঘ

  Triple test

  ঙ

  Double test
• Diseases due to metabolic error include
  ক

  Tuberous xanthoma

  খ

  Osteoma cutis

  গ

  Porphyria cutanea tarda

  ঘ

  Juvenile xanthogranuloma

  ঙ

  Ataxia telangiectasia
• The following statements is/are true regarding gene
  ক

  It is always a fragment of DNA in human

  খ

  It is a part of RNA in prokaryotes

  গ

  Genetic mutation does not always cause disease

  ঘ

  It contains only exon

  ঙ

  It is contained only in nuclear DNA
• True statement regarding single gene disorder are
  ক

  Fragile X-Syndrome is X linked recessive

  খ

  Congenital adrenal hyperplasia is autosomal recessive

  গ

  Hemophilia is X linked recessive

  ঘ

  Cystic fibrosis is autosomal dominant

  ঙ

  Thalassaemia is autosomal dominant
• Genetic code is:
  ক

  Non-overlapping

  খ

  Universal

  গ

  Commaless

  ঘ

  Ambiguous

  ঙ

  Non-redundant
• Examples of trinucleotide repeat expansion disease
  ক

  Fragile X syndrome

  খ

  Myotonic dystrophy

  গ

  Friedreich’s ataxia

  ঘ

  Cystic fibrosis

  ঙ

  Duchenne’s muscular dystrophy
• In the laboratory analysis of DNA
  ক

  Gene probes must be single stranded to be of use in hybridization

  খ

  Polymerase chain reaction is used to amplify small segments of genomic DNA

  গ

  Restriction fragment length polymorphisms are useful in gene tracking

  ঘ

  A high combination fraction suggest that a gene and its marker are closely linked

  ঙ

  Restriction endonucleases are used to join small fragments of DNA.
• In anencephaly
  ক

  Polyhydramnios is present

  খ

  The cranial neuropore fails to close

  গ

  Nuchal translucency is increased

  ঘ

  Maternal vitamin B12 deficiency is present

  ঙ

  Alpha-fetoprotein level is low
• Turner syndrome is associated with
  ক

  Primary amenorrhoea

  খ

  45XO karyotype

  গ

  Rare mental retardation

  ঘ

  Autosomal dominant disease

  ঙ

  Male phenotype.
• Feature/s of Turners syndrome is/are
  ক

  Low hairline

  খ

  Shield chest

  গ

  Webbed neck

  ঘ

  Pitting edema

  ঙ

  Ventricular septal defect
• Turners syndrome is characterized by
  ক

  Coarctation of the aorta

  খ

  45 XY chromosomal abnormality

  গ

  Secondary amenorrohea

  ঘ

  Multicystic ovary

  ঙ

  Absence of pubic hair
• Karyotypes that indicate Turners syndrome are
  ক

  45

  খ

  X

  গ

  46

  ঘ

  X

  ঙ

  del (X

  চ

  47

  ছ

  XXX

  জ

  47

  ঝ

  XXY
• Primary amenorrhea in a girl with normal external genitalia indicates
  ক

  Turner’s syndrome

  খ

  Congenital adrenal hyperplasia

  গ

  Mullerian agenesis

  ঘ

  Kallman’s syndrome

  ঙ

  Craniopharyngioma
• In Turners syndrome
  ক

  Coarctation of the aorta may occur

  খ

  Characteristic clrromosoma] structure is 45 XY

  গ

  Secondary amenorrhea is usual

  ঘ

  The ovaries are multicystic

  ঙ

  Pubic hair is absent
• Turner syndrome
  ক

  Most common cause of primary amenorrhoea

  খ

  Secondary sexual characteristics remain absent

  গ

  Incidence is around 1 in 500 live born female

  ঘ

  Usually presents with tall stature

  ঙ

  Gonads are usually functional
• A person with karyotype 47 xxy is associated with
  ক

  A single barr body

  খ

  Gynaecomastia

  গ

  Mongolism

  ঘ

  Presence of an ovotestis

  ঙ

  Mental retardation
• Following are the features of Klinefelter's syndrome
  ক

  Phenotype is male

  খ

  Usually are infertile

  গ

  azospermia is universal

  ঘ

  Most common karyotype is 47 XXX

  ঙ

  Usually have short stature

  চ

  All have- gynaecomastia