First pass metabolism MCQ 8+

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• Following are partial agonist drugs
  ক

  Clonidine

  খ

  Pindolol

  গ

  Acebutolol

  ঘ

   methyl-dopa

  ঙ

  Reserpine
• Which of the following statements are correct
  ক

  A drug-receptor interaction generally involves co-valent binding

  খ

  The sympathetic supply to the sweat glands is cholinergic

  গ

  Antagonists slowly dissociate from the receptor

  ঘ

  Nicotine is a partial agonist

  ঙ

  β- receptor stimulation causes inhibition of adenylate cyclase
• Which of the following pairs of drugs compete for the same receptor
  ক

  Cimetidine and histamine

  খ

  Strychnine and glycine

  গ

  Dopamine and haloperidol

  ঘ

  Morphine and atropine

  ঙ

  Morphine and noradrenaline
• Drugs act by binding with
  ক

  Enzyme

  খ

  Receptor

  গ

  Ion channel

  ঘ

  Plasma protein

  ঙ

  Hormone
• Drugs producing effects via non-receptor mechanism are
  ক

  Mannitol

  খ

  Magnesium trisillicate

  গ

  Ispaghula

  ঘ

  Sumatriptan

  ঙ

  Morphine
• Drugs acting upon same receptors are
  ক

  Ranitidine and histamine

  খ

  Glycine and strychnine

  গ

  Dopamine and haloperidol

  ঘ

  Atropine and morphine

  ঙ

  Propranolol and ipratropium
• Drugs exert their effect by binding with
  ক

  Carrier proteins

  খ

  Enzymes

  গ

  Receptors

  ঘ

  Plasma proteins

  ঙ

  Smooth endoplasmic reticulum
• Drugs with a high hepatic first-pass effect include
  ক

  Levodopa

  খ

  Morphine

  গ

  Diazepam

  ঘ

  Digoxin

  ঙ

  Phenytoin