Endocrinology MCQ 108+

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• Nitrogen balance is
  ক

  Positive during recovery from illness

  খ

  Negative in untreated diabetes mellitus

  গ

  Positive during normal pregnancy

  ঘ

  Positive during starvation

  ঙ

  Positive during prolonged immobilization
• An increase in body fat content increases the
  ক

  Survival time during fasting

  খ

  Survival time in cold water

  গ

  Probability of mortality

  ঘ

  Percentage of water in the body

  ঙ

  Specific gravity of the body
• Hair growth may be greatly influenced by
  ক

  Thyroid hormone

  খ

  Croticosteroids

  গ

  Growth hormone

  ঘ

  Oestrogen

  ঙ

  Parathyroid hormone
• Followings are the peptide hormones
  ক

  Gonadotrophines

  খ

  Insulin

  গ

  Oxytocin

  ঘ

  Epinephrine

  ঙ

  Thyroxin
• Characteristic findings of ricket include
  ক

  Hypophosphatamia due to secondary hyperparathyodism

  খ

  Increased serum alkaline phosphatase

  গ

  Deformity of long bones

  ঘ

  Epiphysial expansion of lower radius on X-Ray

  ঙ

  High 25- hydroxy-cholecalciferol
• Complication/s of obesity is/are
  ক

  Pseudotumor cerebri

  খ

  Depression

  গ

  NAFLD

  ঘ

  COPD

  ঙ

  Osteoporosis
• In obesity, serum concentration of the following hormones is/are increased
  ক

  Serum cortisol

  খ

  Serum insulin

  গ

  Serum T3

  ঘ

  Serum growth hormone

  ঙ

  Serum T4
• VIPoma is characterized by
  ক

  Chronic diarrhoea

  খ

  Hypokalaemia

  গ

  Hypoglycaemia

  ঘ

  Peptic ulcer

  ঙ

  Necrolytic migratory erythema
• Clinical features of phaeochromocytoma are
  ক

  Abdominal pain

  খ

  Anxiety

  গ

  Headache

  ঘ

  Diarrhoea

  ঙ

  Weight gain
• Autoimmune polyglandular syndrome-1 include
  ক

  Addison's disease

  খ

  Hypoparathyroidism

  গ

  Grave's disease

  ঘ

  Vitiligo

  ঙ

  Myasthenia gravis
• Functions of angiotensin-II are to
  ক

  Increase ADH secretion

  খ

  Promote K excretion

  গ

  Increase tubular reabsorption of Na+

  ঘ

  Stimulate aldosterone synthesis

  ঙ

  Dilate blood vessels
• Functions of angiotensin-II include
  ক

  Generalized vasoconstriction

  খ

  Secretion of aldosterone

  গ

  Afferent arteriolar constriction

  ঘ

  Secretion of ADH

  ঙ

  Distal tubular reabsorption of chloride
• Function of angiotensin II are to increase
  ক

  ADH Secretion

  খ

  Aldosterone secretion

  গ

  Thirst by central mechanism

  ঘ

  Urine output

  ঙ

  Efferent arteriolar diameter of kidney
• Fasting hypoglycaemia may be seen in
  ক

  Insulinoma

  খ

  Severe hepatic disease

  গ

  Alcohol intoxication

  ঘ

  Adrenal insufficiency

  ঙ

  Cushing’s syndrome
• Hormones causing glycolysis
  ক

  Insulin

  খ

  Thyroxine

  গ

  Catecholamines

  ঘ

  Growth hormone

  ঙ

  Pancreatic polypeptide
• Fasting hypoglycemia occurs in
  ক

  Insulinoma

  খ

  Severe hepatic disease

  গ

  Alcohol intoxication

  ঘ

  Prolactinoma

  ঙ

  Thyrotoxicosis
• Hypoglycemia may occur in
  ক

  Panhypopituitarism

  খ

  Addison's disease

  গ

  Hypothyroidism

  ঘ

  Glucagonoma

  ঙ

  Prolactinoma
• The hormones causing glycolysis is/are
  ক

  Insulin

  খ

  Glucagon

  গ

  Cortisol

  ঘ

  T3 and T4

  ঙ

  Pancreatic polypeptide
• Musculo-skeletal complications of diabetes mellitus include
  ক

  Neuropathic joint

  খ

  Adhesive capsulitis of shoulder joint

  গ

  Diffuse idiopathic skeletal hyperostosis

  ঘ

  Osteoporosis

  ঙ

  Osteopetrosis
• Statement about hypoglycaemic agents include
  ক

  Glipizide produces less hypoglycemia compared to Glibenclamide

  খ

  Pioglitazone may provoke cardiac congestion

  গ

  Metformin increases hepatic glucose out put

  ঘ

  Repeglinide is euglycemic

  ঙ

  Insulin glergine is shorter acting than isophene insulin
• Macrovascular complicatons of Diabetes mellitus are
  ক

  Cerebrovascular disease

  খ

  Peripheral arterial disease

  গ

  Retinopathy

  ঘ

  Neuropathy

  ঙ

  Nephropathy
• Regarding treatment of diabetes mellitus
  ক

  Pioglitazone acts as an insulin sensitizer

  খ

  Peptidyl peptidase-IV inhibitor acts as insulin secretogogue

  গ

  Dosage of insulin should be increased in patient with somogyi effect

  ঘ

  Two insulin sensitizer cannot be given

  ঙ

  Metformin cannot be given in non-obese patients
• In patients with diabetes mellitus
  ক

  Blood pressure control target should be lower than that of non diabetic

  খ

  Lipid control target should be lower than that of non-diabetic

  গ

  Periodic fundoscopic examination reduces eye complications

  ঘ

  Angiotensin converting enzyme inhibitor do not prevent progression of nephropathy

  ঙ

  Good glycaemic control do not prevent major diabetic complication
• Secondary diabetes mellitus is associated with
  ক

  Haemochromatosis

  খ

  Acromegaly

  গ

  Pancreatic carcinoma

  ঘ

  Frusemide

  ঙ

  Hypothyroidsm
• The following statements about Pharmacotherapy of Diabetes Mellitus are correct
  ক

  Insulin therapy is always associated with some degree of hypoglycaemia

  খ

  Resistance against human insulin is best treated by changing to bovine insulin

  গ

  Pregnant diabetic patients are best treated by Biguanides because they are not teratogenic

  ঘ

  Human insulin is best therapeutically because of lesser chance of hypoglycaemia

  ঙ

  α-glucosidase inhibitor therapy is equally effective as Sulphonylurea drug in NIDDM
• Skin manifestations in diabetes mellitus are
  ক

  Necrobiosis lipoidica

  খ

  Shin spot

  গ

  Xerosis

  ঘ

  Spider angioma

  ঙ

  Hypertrichosis
• Gestational diabetes mellitus are associated with
  ক

  Intra uterine growth retardation

  খ

  Big baby

  গ

  Pre eclampsia

  ঘ

  Hyperemesis gravidarum

  ঙ

  Polyhydramnios
• Diabetic dermopathy includes
  ক

  Bulla

  খ

  Hyperpigmentation

  গ

  Yellow discoloration of skin

  ঘ

  d Necrobiosis lipoidica

  ঙ

  Ichthyosis
• In diabetic ketoacidosis there is
  ক

  Decreased breakdown of glucose

  খ

  High anion gap acidosis

  গ

  Decreased breakdown of ketones

  ঘ

  Decreased breakdown of glycogen

  ঙ

  Decreased breakdown of fat
• In management of diabetes mellitus
  ক

  Structured education program is mandatory

  খ

  Many oral hypoglycemic agents cause weight gain

  গ

  Basal bolus insulin regime has less chance of hypoglycemia [Davidson’s/750]

  ঘ

  Metformin impairs renal functions

  ঙ

  Incretin drugs cannot be combined with other oral drugs