Drug antagonism MCQ 6+

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• The drug combinations that exhibit physiological antagonism are
  ক

  Salbutamol and histamine on bronchioles

  খ

  Prednisolone and insulin on blood glucose level

  গ

  Acetylcholine and adrenaline on heart

  ঘ

  Isoprenaline and propranolol on bronchioles

  ঙ

  Atropine and pilocarpine on pupil
• A competitive antagonist will
  ক

  Cause parallel shifting of dose-response curve to right

  খ

  Not effect to maximal response of the agonist when the dose of agonist is increased

  গ

  Reduce the maximal response of the agonist

  ঘ

  Bind with receptor by co-valent bond

  ঙ

  Enhances affinity of agonist for the receptor
• A competitive antagonist
  ক

  Binds to the same receptor as the agonist

  খ

  Alters the potency of an agonist

  গ

  Shifts the dose response curve of an agonist to the right

  ঘ

  Decreases the maximum response to antagonist

  ঙ

  Alters the efficacy of an agonist
• Drugs correctly paired with their side effects is/are
  ক

  Valproic acid - teratogenesis

  খ

  Carbamazepine - diplopia

  গ

  Phenobarbitone - drug interaction

  ঘ

  Phenytoin - aplastic anemia

  ঙ

  Diazepam - hepatotoxicity
• Beneficial drug combinations is/are
  ক

  Losartan + thiazide

  খ

  Amoxicillin + clavulanic acid

  গ

  Amiloride + thiazide

  ঘ

  Iron + tetracycline

  ঙ

  Aspirin + prednisolone