Computational Tools In Biotechnology MCQ

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• The first published genesequence which was fully completed was . . .
  ক

  Lambda phage

  খ

  M 13 phage

  গ

  T4 phage

  ঘ

  None of these
• Laboratory work using water, chemicals and drugs is referred to as . . .
  ক

  Insilico

  খ

  Invitro

  গ

  Dry lab

  ঘ

  Wet lab
• The percentage SIMILARITIES and IDENTITIES, respectively, between the two peptide sequences given below will be . . . . . . . . % and . . . . . . . . %.<br>Peptide I: Ala-Ala-Arg-Arg-Gln-Trp-Leu-Thr-Phe-Thr-Lys-Ile-Met-Ser-Glu<br>Peptide II: Ala-Ala-Arg-Glu-Gln-Tyr-Ile-Ser-Phe-Thr-Lys-Ile-Met-Arg-Asp
  ক

  80, 80

  খ

  80, 60

  গ

  60, 60

  ঘ

  90, 60
• Match the methods available on world wide web in Group I for performing the jobs listed in Group II.<br>
  ক

  <table class="table-style-1"> <tr> <td><strong>Group I</strong></td> <td><strong>Group II</strong></td> </tr> <tr> <td>P. Boxshade</td> <td>1. Searching family database</td> </tr> <tr> <td>Q. BCM launcher</td> <td>2. Finding alignments</td> </tr> <tr> <td>R. Prosite</td> <td>3. Displaying alignments</td> </tr> <tr> <td>S. PSI-BLAST</td> <td>4. Searching for multiple alignments</td> </tr></table> P-1, Q-3, R-2, S-4

  খ

  P-2, Q-3, R-2, S-4

  গ

  P-3, Q-4, R-1, S-2

  ঘ

  P-3, Q-2, R-1, S-4
• Match the entries in the Group I with the entries in Group II.<br>
  ক

  <table class="table-style-1"> <tr> <td><strong>Group I</strong></td> <td><strong>Group II</strong></td> </tr> <tr> <td>P. Threading</td> <td>1. Gene duplication</td> </tr> <tr> <td>Q. FASTA</td> <td>2. Fold prediction</td> </tr> <tr> <td>R. Profile</td> <td>3. HMM</td> </tr> <tr> <td>S. Paralogs</td> <td>4. k-tuple</td> </tr></table> P-2, Q-1, R-3, S-4

  খ

  P-2, Q-4, R-3, S-1

  গ

  P-3, Q-4, R-2, S-1

  ঘ

  P-1, Q-4, R-3, S-2
• Proteomics is the study of . . .
  ক

  Set of carbohydrates

  খ

  Set of proteins

  গ

  Set of specific proteins in the cell

  ঘ

  Set of entire proteins in a cell
• Somethong performed on computer or computer simulation is . . .
  ক

  Insilico

  খ

  Silico

  গ

  Invitro

  ঘ

  All of these
• The amino acid substitution matrices in decreasing order of stringency for comparing protein sequences are
  ক

  PAM250, PAM120, PAM100

  খ

  PAM100, PAM120, PAM250

  গ

  PAM250, PAM100, PAM120

  ঘ

  PAM120, PAM250, PAM100
• Which one of the following methods is used to test the significance of a predicted phylogeny?
  ক

  Bootstrap

  খ

  Maximum likelihood

  গ

  Maximum parsimony

  ঘ

  Minimum evolution
• Which one of the following is not an algorithm for building phylogenetic trees?
  ক

  Maximum parsimony

  খ

  Neighbor joining

  গ

  Maximum likelihood

  ঘ

  Bootstrap
• The retrivel and search tool of the NCBI is . . .
  ক

  Sakura

  খ

  Webin

  গ

  Entrez

  ঘ

  None of these
• Carl Woese used the gene sequence of which one of the following for phylogenetic taxonomy of prokaryotes?
  ক

  A ribosomal RNA of large ribosomal subunit

  খ

  A ribosomal RNA of small ribosomal subunit

  গ

  A ribosomal protein of large ribosomal subunit

  ঘ

  A ribosomal protein of small ribosomal subunit
• PDB is a . . .
  ক

  Composite database for sugar

  খ

  Dimensional database for micromolecules

  গ

  Primary database for macromolecules

  ঘ

  Electrophoresis database
• The process in which macromolecules are released out of cells is known as . . .
  ক

  Exocytosis

  খ

  Pinocytosis

  গ

  Phagocytosis

  ঘ

  Endocytosis
• The algorithm for BLAST is based on
  ক

  Dynamic Programming

  খ

  Hidden Markov Model

  গ

  k-tuple analysis

  ঘ

  Neural Network
• The term "Flybase" is a . . .
  ক

  Model organism database

  খ

  Biodiversity database

  গ

  Biomolecular database

  ঘ

  Literature database
• Which one of these is a nucleotide sequence data base?
  ক

  TREMBL

  খ

  EMBL

  গ

  SWISS

  ঘ

  PROSITE
• Number of unrooted trees in a phylogeny of five sequences is
  ক

  3

  খ

  15

  গ

  105

  ঘ

  945
• Match the items in Group I with an appropriate description in Group II.<br>
  ক

  <table class="table-style-1"> <tr> <td><strong>Group I</strong></td> <td><strong>Group II</strong></td> </tr> <tr> <td>P. UPGMA</td> <td>1. Protein sequence database</td> </tr> <tr> <td>Q. CLUSTAL</td> <td>2. Phylogenetic analysis</td> </tr> <tr> <td>R. SWISS-PROT</td> <td>3. 3-D structure visualization</td> </tr> <tr> <td>S. RasMol</td> <td>4. Multiple sequence alignment</td> </tr></table> P-4, Q-1, R-2, S-3

  খ

  P-2, Q-4, R-1, S-3

  গ

  P-2, Q-3, R-1, S-4

  ঘ

  P-2, Q-1, R-4, S-3
• An example of a program for constructing a phylogenetic tree
  ক

  PHYLIN

  খ

  Phrap

  গ

  ProDom

  ঘ

  PHDsec
• Identify the character-based method(s) used for the construction of a phylogenetic tree.<br>P. Maximum parsimony<br>Q. Neighbor joining<br>R. Maximum likelihood<br>S. Bootstrapping
  ক

  Q only

  খ

  P and R only

  গ

  Q and S only

  ঘ

  S only
• The suitable substitution matrix to align closely related sequences is
  ক

  PAM 250 or BLOSUM 80

  খ

  PAM 40 or BLOSUM 80

  গ

  PAM 120 or BLOSUM 40

  ঘ

  PAM 250 or BLOSUM 40
• An example of a derived protein structure database is
  ক

  Pfam

  খ

  SCOP

  গ

  GEO

  ঘ

  Prosite
• Accession number is a unique identification assigned to a
  ক

  Single database entry for DNA/Protein

  খ

  Single database entry for DNA only

  গ

  Single database entry for Protein only

  ঘ

  Multiple database entry for DNA/Protein
• Which of the following is a model organism database?
  ক

  GOLD SCOP

  খ

  PRO

  গ

  SGD GOL

  ঘ

  SGD
• Which one of the following is a database of protein sequence motifs?
  ক

  PROSITE

  খ

  TrEMBL

  গ

  SWISSPROT

  ঘ

  PDB
• Which of the following statements are CORRECT when a protein sequence database is searched using the BLAST algorithm?<br>P. A larger E-value indicates higher sequence similarity.<br>Q. E-value -10 indicates sequence homology.<br>R. A higher BLAST score indicates higher sequence similarity.<br>S. E-value &gt; 10^-10 indicates sequence homology.
  ক

  P, Q and R only

  খ

  Q and R only

  গ

  P, R and S only

  ঘ

  P and S only
• The length of the minimum unique stretch of DNA sequence that can be found only once in a 3 billion base pairs long genome is
  ক

  14

  খ

  15

  গ

  16

  ঘ

  18
• Program used for essentially local similarity search is
  ক

  BLAST

  খ

  RasMol

  গ

  ExPASY

  ঘ

  SWISS-PROT
• The study of evolutionary relationships is known as
  ক

  Genomics

  খ

  Proteomics

  গ

  Phylogenetics

  ঘ

  Genetics