Complement MCQ 17+

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• The result of complement activation is
  ক

  Chemotaxis of WBC

  খ

  Activation of phagocytic cell

  গ

  Cytolysis of target cell

  ঘ

  Mast cell degranulation

  ঙ

  Type-I hypersensitivity
• Serum C3 Complement 3 level
  ক

  Remains normal in IgA nephropathy

  খ

  Low in SLE

  গ

  Low in post streptococcal glomerulonephritis

  ঘ

  Increases in Henoch Schonlein purpura

  ঙ

  Normal in membranoproliferative glomerulonephritis
• Role of complement component in acute inflammation
  ক

  C3a increases vascular permeability

  খ

  Neutrophils are attracted by C5a

  গ

  C3b helps in phagocytosis

  ঘ

  C4a produces endothelial damage

  ঙ

  C5 activates kinin system
• Complement activation takes place
  ক

  In the presence of endotoxin

  খ

  By more than one pathway

  গ

  As part of the tuberculin reaction

  ঘ

  In anaphylaxis

  ঙ

  By antigen IgA interaction
• Low serum complement is associated with
  ক

  Post infectious glomerulonephritis

  খ

  SLE

  গ

  Infective endocarditis

  ঘ

  Diabetic nephropathy

  ঙ

  Good pasture’s disease
• Components in blood are opsonins
  ক

  Antibody

  খ

  C3b

  গ

  C3a

  ঘ

  IL-2

  ঙ

  GM-CSF
• Regarding complements
  ক

  Deficiency of C1 inhibitor results in angioedema

  খ

  Activation leads to production of anaphylatoxins

  গ

  C5a is regarded as central molecule

  ঘ

  Have no role in opsonization

  ঙ

  Deficiency is associated with many congenital diseases
• Difference between classic and alternate pathway includes
  ক

  The classic pathway needs antibody

  খ

  The alternate pathway needs C5

  গ

  The alternate pathway needs C1 activation

  ঘ

  The classic pathway does not need C5

  ঙ

  The classic pathway needs factor B and D
• Biologically active complement components are
  ক

  C3a

  খ

  C3b

  গ

  C4a

  ঘ

  C4b

  ঙ

  C5b
• Complement component C3b
  ক

  Opsonizes bacteria

  খ

  Is derived from C3

  গ

  Directly kill bacteria

  ঘ

  Is an anaphylatoxin

  ঙ

  c. Is chemotactic
• Complement activation is triggered by
  ক

  IgM

  খ

  IgG

  গ

  Cobra venom

  ঘ

  Exotoxin

  ঙ

  Decay-accelerating factor (DA
• Anaphylatoxins are
  ক

  C3a

  খ

  C5a

  গ

  C4a

  ঘ

  C3b

  ঙ

  C5b
• Activation of complement can be induced by
  ক

  IgG

  খ

  IgM

  গ

  IgD

  ঘ

  IgA

  ঙ

  IgE
• Complement activation by alternative pathway takes place by
  ক

  Shiga toxin

  খ

  Bacterial lipopolysaccharides

  গ

  Viral envelopes

  ঘ

  Cobra venom

  ঙ

  Antigen antibody complex
• Low serum complement level is present in
  ক

  Cryoglobulinaemic vasculitis

  খ

  Sub acute bacterial endocarditis

  গ

  Systemic lupus erythematosus

  ঘ

  IgA nephropathy

  ঙ

  Good Pasture’s disease
• Regarding complement
  ক

  Complement C3b has the opsonizing property

  খ

  Is synthesized by liver

  গ

  Play a role in neutralizing virus

  ঘ

  Is heat resistant

  ঙ

  Level is increased after immunization
• Hypocomplementaemia is found in
  ক

  Systemic lupus erythematosus

  খ

  Post infectious glomerulonephritis

  গ

  Minimal change nephrotic syndrome

  ঘ

  Rheumatoid arthritis

  ঙ

  Acute pyelonephritis