Chromosomal Abnormalities : Duplication MCQ

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• During Strisinger’s model, what happens?
  ক

  The Ribosome slips which causes duplication

  খ

  Parent strand slippage polymerase

  গ

  Daughter strand slippage polymerase

  ঘ

  The polymerase back tracks and resynthesizes
• If a gene undergoes duplication and one of the duplicated copy is mutated to render unexpressed protein. What will be the effect on phenotype?
  ক

  Mutant phenotype

  খ

  Normal phenotype

  গ

  Expression of the mutant gene is less than that would occur if both copy active

  ঘ

  The gene not expressed at all
• Which of the following could be due to duplication?
  ক

  Co-dominance

  খ

  Dominance

  গ

  Incomplete dominance

  ঘ

  Pleiotropy
• Which human chromosomes are involved in Down’s syndrome?
  ক

  6

  খ

  14 and 21

  গ

  8 and 12

  ঘ

  X and Y
• Duplication of Vermillion eye colour gene leads to the expression of the mutant phenotype. Which of the following can lead to normal phenotype with this duplication present?
  ক

  Reverse tandem duplication

  খ

  Duplication of normal eye colour gene

  গ

  Deletion of both the Vermillion gene

  ঘ

  Translocation of Vermillion gene to another chromosome
• Which of the following will have the highest number of eye facete?
  ক

  Ultra bar female Drosophila

  খ

  Heterozygous Bar male Drosophila

  গ

  Heterozygous Bar female Drosophila

  ঘ

  Homozygous bar Female
• If there are two sequences CGCGCGCG and ATATATAT, which will have a higher probability of being duplicated?
  ক

  ATATATATAT

  খ

  CGCGCGCGCG

  গ

  Both will have equal probability

  ঘ

  Both are unlikely to be duplicated
• The Streisinger’s model explains__________
  ক

  Frame shifts

  খ

  Transposition

  গ

  Inversion

  ঘ

  Transition
• Tandem duplication creates ____________ and reverse tandem creates_____________
  ক

  Buckling, looping

  খ

  Hairpin, buckling

  গ

  Buckling, Hairpin

  ঘ

  Loop with turn, hairpin
• Which of the following case of duplication involves more than one chromosome?
  ক

  Tandem duplication

  খ

  Reverse tandem duplication

  গ

  Displaced

  ঘ

  Transposed