Cellular basis of immune response MCQ 12+

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• Main functions of helper T cells
  ক

  Activate CD8+ cells via IL-2

  খ

  Secrete IL-2

  গ

  Activate macrophages through gamma IFN

  ঘ

  Activate B cells via IL-2

  ঙ

  Activate natural killer cells
• T cells have following characteristics
  ক

  Are produced in bone marrow in adult

  খ

  Are of two types CD4+ and CD8+

  গ

  Mature in thymus and bone marrow

  ঘ

  Produce antibody

  ঙ

  Takes part in ADCC
• Cytotoxic T cells are involved in the following functions
  ক

  Lysis of viral infected cells

  খ

  Graft rejection

  গ

  Tumor destruction

  ঘ

  Antibody production

  ঙ

  Antigen presentation
• Conditions associated with T cell immunodeficiency
  ক

  Hodgkin's disease

  খ

  Wiscott-Aldrich syndrome

  গ

  Di George’s syndrome

  ঘ

  Tay-Sach's disease

  ঙ

  Down syndrome
• T cell functions are assessed by
  ক

  Skin testing

  খ

  Lymphocyte proliferation assay

  গ

  Complement fixation test (CF

  ঘ

  Precipitation test

  ঙ

  Agglutination test
• B cell immunodeficiency states are
  ক

  X link agammaglobulinaemia

  খ

  Hyper IgM syndrome

  গ

  Selective IgA deficiency

  ঘ

  Di George’s syndrome

  ঙ

  Hereditary angioedema
• Immunodeficient disease states are
  ক

  Chronic granulomatous disease

  খ

  Hereditary angioedema

  গ

  Chronic mucocutaneous candidiasis

  ঘ

  Idiopathic thrombocytopenic purpura

  ঙ

  IgA nephropathy
• Characteristic features of T-cell independent activation of B cells
  ক

  No memory cells are produced

  খ

  Capsulated bacteria may cause such activation

  গ

  Class switching does not occur

  ঘ

  Antigen is usually multivalent polypeptide

  ঙ

  All classes of immunoglobulins are produced
• T cell marker include
  ক

  CD3

  খ

  CD4

  গ

  CD8

  ঘ

  CD10

  ঙ

  CD20
• CD4 lymphocytes
  ক

  Play role in delayed type of hypersensitivity

  খ

  Possess CD3 protein on their surface

  গ

  Secrete IL-1

  ঘ

  Help B ceil to develop into plasma cei!

  ঙ

  Play role in granuloma formation
• Cytotoxic T cells are involved in
  ক

  Lysis of virus infected cells

  খ

  Graft rejection

  গ

  Tumor destruction

  ঘ

  Antibody production

  ঙ

  Antigen presentation
• Helper T-cell
  ক

  Needs MHC molecule for antigen recognition

  খ

  Produces memory cell

  গ

  Provides help for both humoral and cell mediated immunity

  ঘ

  Has receptor for EBV

  ঙ

  Produces IL-1