Autonomic pharmacology MCQ 41+

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• Eicosanoid include following substances
  ক

  Prostaglandin

  খ

  Thrombaxane

  গ

  Leukotrienes

  ঘ

  Sphingomyelin

  ঙ

  Gangleosides
• 5-hydroxytryptamine
  ক

  Is found primarily in the gastro intestinal tract

  খ

  Is metabolized by monoamineoxidase (MA

  গ

  Is a vasodilator.

  ঘ

  Is depleted from body stores by guanethidine

  ঙ

  Action is antagonized by dopamine
• Which of the following drugs are useful in controlling motion sickness?
  ক

  Hyoscine

  খ

  Diphenhydramine

  গ

  Metoclopramide

  ঘ

  Haloperidol

  ঙ

  Atropine
• The following drugs are used to prevent motion sickness
  ক

  Hyoscine

  খ

  Promethazine

  গ

  Cinnarizine

  ঘ

  Metoclopramide

  ঙ

  Chlorpromazine
• The following drugs could significantly impair the ability to drive an automobile
  ক

  Diphenhydramine

  খ

  Chlorpheniramine

  গ

  Meclizine

  ঘ

  Levocetrizine

  ঙ

  Fexofenadine
• First-generation anti-histamines are
  ক

  Chlorpheniramine

  খ

  Promethazine

  গ

  Cetrizine

  ঘ

  Loratadine

  ঙ

  Fexofenadine
• Antihistamines having less sedative effect are
  ক

  Loratadin

  খ

  Fexofenadin

  গ

  Chlorpheniramine meleate

  ঘ

  Meclizine

  ঙ

  Promethazine
• More sedating anti-histamines are
  ক

  Chlorpheniramine

  খ

  Promethazine

  গ

  Desloratadine

  ঘ

  Loratadine

  ঙ

  Fexofenadine
• Histamine is stored in
  ক

  Basophil

  খ

  Cells in the gastric mucosa

  গ

  Platelet

  ঘ

  Neurons in the CNS

  ঙ

  White blood cell
• receptor blockade effects of non-selective blockers include
  ক

  Cold extremities

  খ

  Bronchoconstriction in asthmatic patient

  গ

  Bradycardia

  ঘ

  Hypoglycemia

  ঙ

  Postural hypotension
• 2-receptor blockade by propranolol leads to
  ক

  Reduced blood supply in skeletal muscle

  খ

  Bronchoconstriction in asthmatic patient

  গ

  Hallucinations and nightmares

  ঘ

  Decreased cardiac output

  ঙ

  Decreased peripheral resistance
• Blockade of 2 receptors causes
  ক

  Bronchoconstriction

  খ

  Cold extremities

  গ

  Bradycardia

  ঘ

  Hyperglycaemia

  ঙ

  Hypotension
• Following is/are the adverse effects of propranolol due to blocking of the B2 receptors
  ক

  Bronchoconstriction

  খ

  Peripheral vasoconstriction

  গ

  Bradycardia

  ঘ

  Hypotension

  ঙ

  Cardiac depression
• Atropine substitute are
  ক

  Tropicamide

  খ

  Ipratropium bromide

  গ

  Hyoscine butyl bromide

  ঘ

  Scopolamine

  ঙ

  Cocaine
• Dilatation of the eye may be obtained by local administration of
  ক

  Homatropin

  খ

  Cocaine

  গ

  Phenylephrine

  ঘ

  Physostigmine

  ঙ

  Salbutamol
• Atropine causes:
  ক

  Paralysis of accommodation for near vision

  খ

  Difficulty in micturation.

  গ

  Constriction of pupil

  ঘ

  Constriction of the bronchi

  ঙ

  Diarrhoea
• Subcutaneous atropine injection in the healthy young subjects may produce
  ক

  An increase in heart rate

  খ

  A decrease in salivation

  গ

  Constriction of the pupil

  ঘ

  Hypnotic effect

  ঙ

  Accommodation of the lens for near vision
• Atropine causes
  ক

  Cycloplegia

  খ

  Bradycardia

  গ

  Urinary retention

  ঘ

  Bronchodilatation

  ঙ

  Decrease of intraocular pressure (IO
• Atropine
  ক

  May cause bradycardia

  খ

  Dilates pupil

  গ

  Has shorted duration of action than glycopyrrolate

  ঘ

  Increases physiological dead space

  ঙ

  Has both muscarinic and nicotinic effects
• Atropine or its substitutes is/are used to treat
  ক

  Bronchial asthma

  খ

  Motion sickness

  গ

  Parkinson’s disease

  ঘ

  Glaucoma

  ঙ

  Myasthenia gravis
• Cholinergic crisis may presents with
  ক

  Abdominal cramp

  খ

  Miosis

  গ

  Diaphoresis

  ঘ

  Respiratory distress

  ঙ

  Edrophonium induced improvement
• Muscarinic features of organophosphorus compound poisoning are
  ক

  Bronchorrhoea

  খ

  Meiosis

  গ

  Tachycardia

  ঘ

  Fasciculation of muscles

  ঙ

  Hot

  চ

  dry & flushed skin
• In anaphylactic shock, following drugs are used to raise blood pressure
  ক

  Adrenaline

  খ

  Noradrenaline

  গ

  Dopamine

  ঘ

  Promethazine

  ঙ

  Hydrocortisone
• The beneficial effects of adrenaline in anaphylactic shock are:
  ক

  Bronchodilatation causing relief of severe dyspnoea and laryngospasm

  খ

  Vasoconstriction causes rise of blood pdressure

  গ

  Increased cardiac output leading to increased coronary blood flow

  ঘ

  Stabilizing the mast cell membrane

  ঙ

  Increased renal blood flow
• Indications of adrenaline are
  ক

  Anaphylactic shock

  খ

  Acute severe asthma

  গ

  Along with local anaesthetics

  ঘ

  Hypertension

  ঙ

  Ischemic heart disease
• Drugs used in organophosphorus compound poisoning are
  ক

  Atropine

  খ

  Pralidoxime

  গ

  Physostigmine

  ঘ

  Pilocarpine

  ঙ

  Diazepam
• The muscarinic actions of acetylcholine include
  ক

  Slowing of the heart

  খ

  Constriction of the pupil

  গ

  Increased secretions in the GIT

  ঘ

  Accommodation of the eye for distant vision

  ঙ

  Decreased peristalsis
• Effects mediated by -adrenoceptors include
  ক

  Peripheral arteriolar dilatation

  খ

  Relaxation of pregnant myometrium

  গ

  Muscle tremor

  ঘ

  Mydriasis

  ঙ

  Decreased myocardial contractility
• Stimulation of beta-2 receptor causes
  ক

  Bronchodilatation

  খ

  Glycogenolysis in liver

  গ

  Relaxation of gravid uterine muscle.

  ঘ

  Vasoconstriction

  ঙ

  Increase in blood pressure
• Which of the following statements regarding adrenergic receptor activation are correct
  ক

  β2 activation in skeletal blood vessels produces vasodilation

  খ

  Postsynaptic -1 activation leads to vasoconstriction

  গ

  Presynaptic 2 activation causes vasodilation

  ঘ

  β1 activation in kidney decreases renin activity

  ঙ

  β2 activation in bronchial smooth muscle leads to bronchoconstriction