Apoptosis MCQ 6+

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• Apoptotic bodies can be recognized by the presence of _____________________ on the surface.
  ক

  phosphatidylserine

  খ

  phosphatidylcholine

  গ

  phosphatidylinositol

  ঘ

  phosphatidyltyrosine
• Which of the following is involved in the intrinsic pathway of apoptosis?
  ক

  cytochrome a

  খ

  cytochrome b

  গ

  cytochrome c

  ঘ

  cytochrome d
• Which family of proteins regulates the intrinsic pathway of apoptosis?
  ক

  Bcl-2

  খ

  Bcl-4

  গ

  Caspase-2

  ঘ

  Caspase-8
• The last proteins to involve in the apoptotic pathway induced by TNF are ______________________
  ক

  caspase-2

  খ

  procaspase-2

  গ

  caspase-8

  ঘ

  procaspase-8
• The TNFR1 is a trimeric receptor.
  ক

  True

  খ

  False
• Which of the following is also termed as a death receptor?
  ক

  TNFR1

  খ

  TNFR2

  গ

  TNFR3

  ঘ

  TNFR4
• Which of the following is an extracellular messenger of apoptosis?
  ক

  serine

  খ

  tumor necrosis factor

  গ

  ribozyme

  ঘ

  translation inhibitor
• Cytokines serve as _____________________ for apoptosis.
  ক

  internal stimuli

  খ

  external stimuli

  গ

  inhibitors

  ঘ

  substitutes
• Inactivation of which of the following leads to shrinkage of the nucleus?
  ক

  lamin

  খ

  tubulin

  গ

  actin

  ঘ

  gelsolin
• Inactivation of which of the following leads to detachment of the apoptotic cell?
  ক

  FAK

  খ

  PKB

  গ

  PKC

  ঘ

  RAF1
• The CED3 gene product in nematodes has homologous _______________ in mammals.
  ক

  kinases

  খ

  esterases

  গ

  caspases

  ঘ

  endonucleases
• Apoptosis is programmed cell death.
  ক

  True

  খ

  False
• When was the term apoptosis coined?
  ক

  1972

  খ

  1982

  গ

  1992

  ঘ

  2002
• Which of the following type of cells recognize and kill the abnormal pathogen infected cells?
  ক

  Mast cells

  খ

  B-lymphocytes

  গ

  T-lymphocytes

  ঘ

  Neutrophils
• Morphological features in apoptotic cells include
  ক

  Nuclear fragmentation

  খ

  Chromatin condensation

  গ

  Cytoplasmic blebs

  ঘ

  Nuclear pyknosis

  ঙ

  Cell swelling
• Statements regarding apoptosis are
  ক

  It is a programmed cell death

  খ

  The dead cells are rapidly cleared

  গ

  It may co-exist with necrosis

  ঘ

  Inflammation surrounds the apoptotic focus

  ঙ

  Cell membrane damage is a constant feature
• Features of apoptosis are
  ক

  Reduced cell size

  খ

  Fragmentation of cell nucleus

  গ

  Disrupted plasma membrane of cells

  ঘ

  Inflammation in adjacent tissue

  ঙ

  Enzymatic digestion of cellular contents
• Features of apoptosis include
  ক

  Chromatin condensation

  খ

  Formation of cytoplasmic blebs and apoptotic bodies

  গ

  Phagocytosis of apoptotic cells by macrophage

  ঘ

  Cellular swelling

  ঙ

  Inflammation
• Apoptosis is triggered by
  ক

  p53

  খ

  Fas-Fas-ligand

  গ

  bcl2

  ঘ

  Superoxide dismutase

  ঙ

  Nitric oxide