Fusidic acid + Hydrocortisone

Introduction

Fusidic acid + hydrocortisone is a combination medication used topically to treat skin conditions characterized by inflammation and bacterial infection. Fusidic acid is an antibiotic that combats bacterial infections, while hydrocortisone is a corticosteroid that reduces inflammation and itching.

Uses

This combination is used to treat:

Bacterial Skin Infections: Fusidic acid targets Gram-positive bacteria, including Staphylococcus aureus, commonly found in skin infections.
Inflammatory Skin Conditions: Hydrocortisone alleviates symptoms of inflammation, redness, and itching associated with conditions like eczema, dermatitis, and psoriasis.

It is typically used for conditions where both bacterial infection and inflammation are present, helping to manage and resolve these issues simultaneously.

Brand Name	Fusidic acid + Hydrocortisone
Type
Weight
Generic	Fusidic acid + Hydrocortisone
Manufacturer
Available in	English বাংলা

Mechanism of Action

Fusidic acid works by inhibiting bacterial protein synthesis, specifically by preventing the binding of aminoacyl-tRNA to the ribosomal subunit, thus disrupting bacterial growth. Hydrocortisone acts as an anti-inflammatory agent by suppressing the migration of leukocytes to sites of inflammation, inhibiting the release of inflammatory mediators, and stabilizing cell membranes.

How Long Does It Take to Work?

The onset of action can vary. Fusidic acid starts to show antibacterial effects within a few days of application, while hydrocortisone provides relief from inflammation and itching usually within 24 to 48 hours. Full benefits may take a few days of consistent use.

Absorption

When applied topically, the absorption of fusidic acid and hydrocortisone through the skin is minimal. Both drugs are primarily active at the site of application with limited systemic absorption, reducing the risk of systemic side effects.

Route of Elimination

Topically applied fusidic acid and hydrocortisone have minimal systemic absorption. Fusidic acid, when absorbed, is metabolized in the liver and excreted in the urine. Hydrocortisone is also metabolized in the liver and excreted in the urine. Systemic absorption from topical application is usually low but should be considered, especially in long-term use.

Dosage

Adults: This Cream should be applied 3 times daily and gently massaged onto the affected areas for 2 weeks. A shorter course should be considered if symptoms improve.

Children: It is not recommended in children under 3 years of age.

The usual dosage involves applying a thin layer of the combination cream or ointment to the affected area 2 to 3 times a day. The exact dosage and duration depend on the severity of the condition and the healthcare provider's recommendations. It's important to follow the prescribed regimen to avoid overuse and potential side effects.

Administration

Apply the cream or ointment directly to the affected skin area. The application should be thin and spread evenly. Avoid applying to large areas or under occlusive dressings unless directed by a healthcare provider. Wash hands thoroughly after application to prevent spreading the medication to other areas.

Side Effects

Common side effects include:

Skin irritation or rash
Burning or stinging sensation
Dryness or peeling of the skin

Rare but serious side effects can include skin thinning, striae, and systemic corticosteroid effects in cases of significant absorption. Consult a healthcare provider if severe reactions occur.

Toxicity

Topical toxicity is rare but can occur with excessive use. Overuse or application on large areas may lead to systemic absorption of hydrocortisone, resulting in potential corticosteroid side effects such as adrenal suppression. If symptoms of overdose or severe reactions occur, discontinue use and seek medical attention.

Precautions

Precautions include:

Avoid use on broken or infected skin unless directed by a healthcare provider.
Do not use in the eyes or on mucous membranes.
Limit use to the affected areas and avoid prolonged use to minimize the risk of side effects.

Regular monitoring may be necessary if used over large areas or for extended periods.

Interaction

There are no significant drug interactions with other topical medications. However, using other topical corticosteroids or antibiotics simultaneously may enhance the risk of side effects or alter effectiveness. Inform your healthcare provider of all products being used.

Disease Interaction

Use with caution in individuals with:

Skin infections not caused by susceptible bacteria.
Systemic infections or immunosuppressive conditions.
Pre-existing skin conditions that may be exacerbated by topical steroids.

Monitoring and adjustment may be required in these cases.

Drug Interaction

Topical interactions are generally minimal. However, caution should be exercised when using other topical medications or corticosteroids concurrently, as they may interact or increase side effects.

Food Interactions

No significant food interactions are known. However, maintaining a balanced diet can support overall skin health and potentially minimize side effects.

Pregnancy Use

Fusidic acid + hydrocortisone is classified as Category C for pregnancy, meaning that risk cannot be ruled out. It should be used during pregnancy only if the benefits outweigh the risks. Consult a healthcare provider for personalized advice if pregnant or planning to become pregnant.

Lactation Use

It is not known whether fusidic acid or hydrocortisone is excreted in human breast milk. Use with caution during breastfeeding, and consider the potential risks and benefits. Discuss with a healthcare provider to determine the best course of action.

Acute Overdose

Acute overdose is unlikely with topical application. However, excessive use or application over large areas can lead to systemic absorption and potential corticosteroid effects. In case of suspected overdose, discontinue use and seek medical advice.

Contraindication

Contraindications include:

Hypersensitivity to fusidic acid, hydrocortisone, or any other component of the formulation.
Skin conditions not caused by bacteria susceptible to fusidic acid.
Active viral or fungal skin infections.

Avoid use in these conditions to prevent exacerbation or complications.

Use Direction

Apply the medication as prescribed, typically to the affected area 2 to 3 times daily. Avoid overuse and follow the healthcare provider’s instructions. Discontinue use if no improvement is observed or if side effects occur.

Storage Conditions

Store at room temperature, away from direct sunlight and moisture. Keep out of reach of children. Do not use beyond the expiration date and dispose of unused medication properly.

Volume of Distribution

The volume of distribution for topical fusidic acid and hydrocortisone is limited due to minimal systemic absorption. The primary effect is localized to the skin area where the medication is applied.

Half Life

The half-life of fusidic acid in systemic circulation is approximately 8 to 12 hours, though this is less relevant for topical use. For hydrocortisone, the half-life can be approximately 1.5 to 2 hours in the systemic circulation. The effects of topical application are localized and prolonged due to depot formulation.

Clearance

Topical fusidic acid and hydrocortisone have minimal systemic clearance due to limited absorption. When absorbed, they are metabolized in the liver and excreted primarily in the urine. Monitoring is less relevant for topical use but should be considered in cases of significant systemic absorption.

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