Introduction
Fexofenadine + Pseudoephedrine is a combination medication used to temporarily relieve the symptoms of seasonal allergies such as sneezing, watery eyes, and runny nose. It is an antihistamine (fexofenadine) and decongestant (pseudoephedrine) combination drug.
Uses For
Fexofenadine + Pseudoephedrine is indicated for treating seasonal allergy symptoms, such as sneezing, nasal stuffiness and itchiness. It is useful for treating congestion due to these allergies.
| Brand Name | Fexofenadine + Pseudoephedrine |
|---|---|
| Type | |
| Weight | |
| Generic | Fexofenadine + Pseudoephedrine |
| Manufacturer | |
| Available in | English বাংলা |
Mechanism of Action
Fexofenadine is an orally active antihistamine that blocks the release of histamine in the body as a result of allergic reactions. Histamine is a substance that causes allergic symptoms. Pseudoephedrine is an orally active decongestant that works by constricting the blood vessels in the nose, thereby reducing nasal congestion.
How Long Does It Take to Work
Relief of symptoms can be noticed within 1 hour from the intake of Fexofenadine + Pseudoephedrine . However, its effect can last up to 12 hours.
Absorption
Fexofenadine + Pseudoephedrine is rapidly and completely absorbed after oral administration with peak plasma concentrations occurring in 1-3 hours.
Route Of Elimination
Fexofenadine + Pseudoephedrine is excreted mainly in the urine as unchanged drug and metabolites.
Dosage
The dosage of Fexofenadine + Pseudoephedrine should be taken exactly as prescribed by the physician. Usually, the recommended doses of Fexofenadine + Pseudoephedrine capsules are one capsule twice a day. The maximum dose is two 120 mg/60 mg oral capsules twice a day. It may be taken with or without food.
Administration
Fexofenadine + Pseudoephedrine tablets should be taken by mouth, usually twice daily. It can be taken with or without food.
Side Effects
Common side effects of Fexofenadine + Pseudoephedrine include drowsiness, dizziness, headache, nausea, dry mouth, upset stomach, and diarrhea.
Toxicity
The adverse effects of Fexofenadine + Pseudoephedrine can become serious if taken in excessive doses. Common toxic symptoms include racing heartbeat, nervousness, tremors, high blood pressure, chest pain, and tingling in the extremities.
Precaution
- Patients with high blood pressure, heart diseases, glaucoma, diabetes, hyperthyroidism, kidney disease, or enlarged prostate should use Fexofenadine + Pseudoephedrine cautiously.
- Patients who are currently taking monoamine oxidase inhibitors (MAOIs) or who have taken them within the past two weeks should not take Fexofenadine + Pseudoephedrine .
- Pregnant women and breastfeeding women should consult their doctor before taking Fexofenadine + Pseudoephedrine .
- Patients who are taking other medications should consult their doctor before taking Fexofenadine + Pseudoephedrine .
- Patients should not take alcohol while taking Fexofenadine + Pseudoephedrine .
Interaction
Fexofenadine + Pseudoephedrine may interact with certain medications such as alcohol, warfarin, and other antihistamines. Therefore, patients should consult their doctor before taking other medications while on Fexofenadine + Pseudoephedrine .
Disease Interaction
Fexofenadine + Pseudoephedrine should be used with caution among elderly patients and those with hepatic or renal impairment.
Drug Interaction
Fexofenadine + Pseudoephedrine may interact with other drugs such as antidepressants, benzodiazepines, oral contraceptives, and antifungals. Therefore, it is important to inform the doctor of any medications being taken before taking Fexofenadine + Pseudoephedrine .
Food Interactions
Fexofenadine + Pseudoephedrine may interact with certain foods, such as food containing a large amount of calcium or aluminum. Therefore, patients should consult their doctor before taking this medication with food.
Pregnancy Use
Fexofenadine + Pseudoephedrine should be avoided during pregnancy unless absolutely necessary. Women should consult their doctor before taking this medication during pregnancy.
Lactation Use
Fexofenadine + Pseudoephedrine should be avoided during lactation unless medically necessary. Women should consult their doctor before taking Fexofenadine + Pseudoephedrine while breastfeeding.
Acute Overdose
The signs of an acute overdose of Fexofenadine + Pseudoephedrine include restlessness, rapid heartbeat, excessive sweating, nausea, vomiting, abdominal pain, blurred vision, confusion, and dizziness.
Contraindication
Fexofenadine + Pseudoephedrine should not be taken in the presence of any known hypersensitivity to any of the ingredients.
Use Direction
Fexofenadine + Pseudoephedrine should be taken exactly as prescribed by the doctor. It should not be taken in larger or smaller amounts than recommended by the doctor.
Storage Condition
Fexofenadine + Pseudoephedrine should be stored at a temperature between 20°C and 25°C. Keep away from direct sunlight and moisture.
Volume of Distribution
The Volume of Distribution of Fexofenadine + Pseudoephedrine is reported to be 1.6 L/Kg.
Half Life
The elimination half-life of Fexofenadine is reported to be 18 hours. The elimination half-life of Pseudoephedrine is reported to be 9.8 hours.
Clearance
The clearance of Fexofenadine is reported to be 17.2 ± 4.3 mL/min/kg. The clearance of Pseudoephedrine is reported to be 24.4 ± 10.3 mL/min/kg.
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