Amitriptyline Hydrochloride + Chlordiazepoxide
Amitriptyline Hydrochloride + Chlordiazepoxide , also known as Limbitrol, is a medication combination used to treat symptoms of anxiety, depression, and chronic pain. It is a combination of two drugs, Amitriptyline Hydrochloride (an antidepressant), and Chlordiazepoxide (a benzodiazepine used to treat anxiety).
Uses for
Amitriptyline Hydrochloride + Chlordiazepoxide is used to treat anxiety, depression, and chronic pain. It can help reduce symptoms of depression, such as loss of interest in activities, feelings of guilt or worthlessness, and slowed thinking; as well as symptoms of anxiety, such as stress, restlessness, and difficulty sleeping. It can also be used to help treat chronic pain, such as headache, backache, and arthritis.
| Brand Name | Amitriptyline Hydrochloride + Chlordiazepoxide |
|---|---|
| Type | |
| Weight | |
| Generic | Amitriptyline Hydrochloride + Chlordiazepoxide |
| Manufacturer | |
| Available in | English বাংলা |
Mechanism of Action
Amitriptyline Hydrochloride + Chlordiazepoxide works by enhancing the effectiveness of serotonin and norepinephrine, two neurotransmitters that influence mood. These neurotransmitters are released in the brain, and can help regulate mood and feelings of well being. This drug combination can also act on the gamma-aminobutyric acid, or GABA, system, which helps control the body’s response to stress.
How Long Does it Take to Work?
Amitriptyline Hydrochloride + Chlordiazepoxide usually begins to work within two weeks of starting treatment. However, the effects of the medication may not be felt until six to eight weeks have passed.
Absorption
Amitriptyline Hydrochloride + Chlordiazepoxide is absorbed well into the blood stream, and reaches peak concentrations in the body within one to two hours after administration.
Route of Elimination
Amitriptyline Hydrochloride + Chlordiazepoxide is mostly eliminated through the kidneys, either in the urine or feces.
Dosage
Optimum dosage varies with the severity of the symptoms and the response of the individual patient. When a satisfactory response is obtained, the dosage should be reduced to the smallest amount needed to maintain the remission. The larger portion of the total daily dose may be taken at bedtime. In some patients, a single dose at bedtime may be sufficient. This tablet in an initial dosage of 3 or 4 tablets daily in divided doses is satisfactory. Or directed by the physican.The dosage for Amitriptyline Hydrochloride + Chlordiazepoxide varies depending on the individual. The recommended starting dose is 10mg of Amitriptyline Hydrochloride and 5mg of Chlordiazepoxide once daily, or twice daily in divided doses. The dosage can be increased gradually depending on patient response. The maximum recommended dosage of Amitriptyline Hydrochloride is 100mg per day, and the maximum dosage of Chlordiazepoxide is 25mg per day.
Administration
Amitriptyline Hydrochloride + Chlordiazepoxide is administered orally, with food or without food. It is important to take this medication at the same time every day, and as prescribed by the doctor. It should not be stopped abruptly, as this can cause withdrawal symptoms. It should be taken in the evening or before bedtime, as it can cause drowsiness.
Side Effects
Common side effects associated with Amitriptyline Hydrochloride + Chlordiazepoxide include drowsiness, dry mouth, constipation, dizziness, nausea, vomiting, blurred vision, confusion, irritability, difficulty urinating, changes in libido, weight gain, and changes in appetite.
Toxicity
Overdose of Amitriptyline Hydrochloride + Chlordiazepoxide can lead to serious side effects, including confusion, coma, and/or death. If overdosage is suspected, contact a poison control center or emergency care immediately.
Precautions
It is important to inform your doctor of any allergies or sensitivities before taking Amitriptyline Hydrochloride + Chlordiazepoxide , as some ingredients may have negative reactions. It is also important to tell your doctor your complete medical history before taking this medication. Some medical conditions, such as glaucoma, urinary problems, or seizures, may interact with the drug and result in serious side effects.
Interactions
Amitriptyline Hydrochloride + Chlordiazepoxide may interact with some other medications. It is important to inform your doctor of any other medications you are taking, such as antibiotics, antifungals, seizure medications, antipsychotics, antianxiety medications, or any other prescription or over the counter medications. Also inform your doctor if you are taking supplements or herbal medications. Some interactions can lead to serious side effects.
Disease Interactions
Amitriptyline Hydrochloride + Chlordiazepoxide may be contraindicated for certain diseases and medical conditions. Some of these include bipolar disorder, heart disease, glaucoma, kidney disease, liver disease, a history of substance abuse, and certain intestinal conditions like inflammatory bowel disease or ulcerative colitis.
Drug Interactions
Amitriptyline Hydrochloride + Chlordiazepoxide can interact with some other medications. This includes some pain medications, seizure medications, antibiotics, antifungals, antipsychotics, antianxiety medications, and any other prescription or over the counter medications you are taking. It is important to tell your doctor of any other medications you are taking, as some interactions can cause serious side effects.
Food Interactions
Amitriptyline Hydrochloride + Chlordiazepoxide can interact with certain foods and beverages. It is important to avoid alcoholic beverages and products containing caffeine while taking this medication. This medication may also have a negative effect when combined with grapefruit juice, so it is best to avoid consuming it while taking this medication.
Pregnancy Use
Amitriptyline Hydrochloride + Chlordiazepoxide is not typically recommended for use during pregnancy. There may be a risk of birth defects in infants exposed to this medication in utero. It is important to discuss the risks with your doctor before taking this medication while pregnant.
Lactation Use
Amitriptyline Hydrochloride + Chlordiazepoxide can be passed through breast milk, and may cause serious side effects in infant. It is important to discuss the risks with your doctor before taking this medication while breastfeeding.
Acute Overdose
An acute overdose of Amitriptyline Hydrochloride + Chlordiazepoxide can be dangerous and potentially deadly. Symptoms of an acute overdose include confusion, coma, and death. If an overdose is suspected, contact a poison control center or emergency care immediately.
Contraindication
Amitriptyline Hydrochloride + Chlordiazepoxide should not be used in patients with certain medical conditions. This includes individuals with liver or kidney disease, glaucoma, a history of substance abuse, or a hypersensitivity to either of the two components. Allergies and sensitivities should also be reported to your doctor before taking this medication.
Use Direction
- Take Amitriptyline Hydrochloride + Chlordiazepoxide as prescribed by your doctor, at the same time each day.
- This medication can cause drowsiness, so do not drive or operate heavy machinery unless your doctor tells you that it is safe to do so.
- Do not stop taking this medication abruptly, as this may cause withdrawal symptoms.
- Inform your doctor of any allergies or sensitivities before taking this medication.
- Inform your doctor of any other medications you are taking or any health conditions.
- Do not take this medication if you are pregnant or breastfeeding unless your doctor tells you otherwise.
- Do not consume alcohol or products containing caffeine while taking this medication.
- Do not consume grapefruit juice while taking this medication.
Storage Conditions
Amitriptyline Hydrochloride + Chlordiazepoxide should be stored in a cool, dry place, away from direct sunlight and moisture. Keep this medication in its original container, and keep it out of reach of children and pets.
Volume of Distribution
Volume of distribution for Amitriptyline Hydrochloride + Chlordiazepoxide has not been determined.
Half-Life
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