Structure and Function of MHC Molecules MCQ

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• When T cells respond to a non-self MHC, it is called __________
  ক

  Alloreactivity

  খ

  Isoreactivity

  গ

  Alloavidity

  ঘ

  Isoavidity
• Class II MHCs are found only on APCs.
  ক

  True

  খ

  False
• At what angle does the TCR sit on the MHC molecules?
  ক

  30°

  খ

  45°

  গ

  60°

  ঘ

  90°
• MHC molecules exhibit ______________ property.
  ক

  Allelic exclusion

  খ

  Somatic hypermutation

  গ

  Co-dominant expression

  ঘ

  Clonal expansion
• Which of the following genes of class II MHCs is most polymorphic?
  ক

  HLA-DP-alpha

  খ

  HLA-DP-beta

  গ

  HLA-DR-beta

  ঘ

  HLA-DR-alpha
• Class II MHCs have 6 genes in its system.
  ক

  True

  খ

  False
• Class I MHC has three genes, HLA-A, HLA-B and HLA-C. Which of the following is the correct order of level of polymorphism?
  ক

  A > B > C

  খ

  B > A > C

  গ

  A > C > B

  ঘ

  B > C > A
• Which of the following does the class III MHC code for?
  ক

  T helper cells

  খ

  T cytotoxic cells

  গ

  T regulatory cells

  ঘ

  Complement proteins
• In humans, what are MHCs called as ________
  ক

  HHC

  খ

  HLA

  গ

  HAT

  ঘ

  HPFC
• In class II MHCs, which two subunits form the binding cleft?
  ক

  Alpha1 and Alpha2

  খ

  Alpha1 and Alpha3

  গ

  Beta1 and Beta2

  ঘ

  Alpha1 and Beta1
• In class I MHCs, which two subunits form the binding cleft?
  ক

  Alpha1 and Alpha2

  খ

  Alpha1 and Alpha3

  গ

  Alpha3 and Beta2

  ঘ

  Alpha1 and Beta2
• Which of the following co-receptors recognizes the beta1 and beta2 microglobulin subunits of class II MHCs?
  ক

  CD24

  খ

  CD4

  গ

  CD8

  ঘ

  CD16
• Which of the following co-receptors recognizes the beta2 microglobulin subunit of class I MHCs?
  ক

  CD24

  খ

  CD4

  গ

  CD8

  ঘ

  CD16
• Which of the following cells recognize the antigens present on the cell surface of the MHC molecules?
  ক

  T cells

  খ

  B cells

  গ

  Mast cells

  ঘ

  Macrophages
• MHC molecules are the set of genes that code cell surface proteins essential for _________
  ক

  Innate immunity system

  খ

  Adaptive immunity system

  গ

  Both innate and adaptive systems

  ঘ

  Coding for proteins is not a function of MHC molecules