Protein Folding MCQ

Test your knowledge with important Protein Folding MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30 + more Protein Folding MCQs at Bissoy

• In a living organism, strong interactions between molecules are formed by a certain type of bond. Name that?
  ক

  Hydrogen bonding

  খ

  Covalent bond

  গ

  Electrostatic interactions

  ঘ

  Van der Waals forces
• Mark the correct statement which depicts the correct statement of protein assay?
  ক

  To determine the amount of protein

  খ

  To characterize the function of the protein

  গ

  To determine the structure of the protein

  ঘ

  To determine the sequence of the protein
• Proteolytic enzyme trypsin cleaves protein at which of these specific sites?
  ক

  Carboxyl side of Alanine, Glycine

  খ

  Carboxyl side of Lysin or Arginine

  গ

  Carboxyl side of aromatic amino acid

  ঘ

  The amino side of aromatic amino acid
• Which one of the following reagent is also known a Sanger’s reagent?
  ক

  1-fluoro-2,4-dinitrobenzene (FDNB)

  খ

  Phenylisothiocyanate

  গ

  Cyanogen bromide

  ঘ

  β-mercaptoethanol
• Among all the heat shock proteins which one is known as chaperonins?
  ক

  Hsp70

  খ

  Hsp32

  গ

  Hsp60

  ঘ

  Hsp30
• Which of these heat shock proteins prevent protein misfolding and maintain polypeptide chain in the unfolded state.
  ক

  Hsp60

  খ

  Hsp28

  গ

  Hsp70

  ঘ

  Hsp32
• Which of the following name is given to molecular chaperones?
  ক

  Allosteric protein

  খ

  Heat shock protein

  গ

  Denaturation protein

  ঘ

  Ribonuclease
• Which sentence is INCORRECT regarding molten globule state of protein?
  ক

  Hydrophobic interaction among non-polar residues

  খ

  The collapsed state

  গ

  It is less compact

  ঘ

  The denatured state
• Which of them contains all the information required to fold the polypeptide chain in its 3-D structure?
  ক

  DNA sequences

  খ

  RNA

  গ

  Histone protein

  ঘ

  Amino acid sequences
• Chaperones are the molecular protein which assists in proper protein folding or prevents them from aggregating.
  ক

  True

  খ

  False
• Protein folding is a process in which a polypeptide folds in to ___________
  ক

  2-D structure

  খ

  Globular form

  গ

  3-D structure

  ঘ

  Linear form
• Which of the following feature is pertaining to the passive model of the refolding of proteins?
  ক

  Both ATP and GTP are required

  খ

  GTP hydrolysis

  গ

  ATP hydrolysis

  ঘ

  No energy expenditure
• Which of the following is not a model for the refolding of misfolded proteins?
  ক

  Passive model

  খ

  Active model

  গ

  Iterative model

  ঘ

  Intermediate model
• Which of the following is the protein Cap of barrel-shaped bacterial Hsp60 like proteins?
  ক

  BIP

  খ

  TCP 1

  গ

  GroEL

  ঘ

  GroES
• Which of the following event increases the diameter of the barrel (Hsp60)?
  ক

  Binding of only cap protein

  খ

  Binding of the only ATP

  গ

  Hydrolysis of ATP

  ঘ

  Binding of ATP and a protein cap
• Which of the following is a complex protease, used to destroy protein molecules?
  ক

  Ubiquitin

  খ

  Chaperone

  গ

  Proteosome

  ঘ

  Proteasome
• What is the fate of misfolded proteins when attempts to refold it fail?
  ক

  Sent back to the ribosome

  খ

  Stored in vacuole

  গ

  Kept in the cytosol

  ঘ

  Destroyed by proteolysis
• A misfolded protein or a protein with the abnormally exposed hydrophobic region is not merely useless to the cell, they can be dangerous.
  ক

  False

  খ

  True
• Which of the following does not lead to exposure of hydrophobic amino acids on the surface of a protein?
  ক

  Failed to fold correctly

  খ

  Protein suffered an accident

  গ

  Failed to find its normal partner subunit

  ঘ

  Proper folding of proteins
• What are the Hsp60 like proteins called in bacterial cells?
  ক

  BIP

  খ

  TCP 1

  গ

  GroES

  ঘ

  GroEL
• Which of the following proteins help in the refolding of proteins in Endoplasmic Reticulum?
  ক

  TCP 1

  খ

  GroES

  গ

  GroEL

  ঘ

  BIP
• What is the interval of time for which proteins are stored inside the barrel-shaped proteins?
  ক

  60 seconds

  খ

  45 seconds

  গ

  30 seconds

  ঘ

  15 seconds
• What are Hsp60 like proteins known as in the cytosol of a vertebrate cell?
  ক

  Hsp70

  খ

  from

  গ

  GroEL

  ঘ

  TCP 1
• Which type of chaperones form an “isolated chamber”?
  ক

  Hsp30

  খ

  Hsp40

  গ

  Hsp70

  ঘ

  Hsp60
• Hsp60 like proteins act before the target protein leaves the ribosome.
  ক

  True

  খ

  False
• Which of the following phenomenon allows chaperones to recognize a wide variety of misfolded structures?
  ক

  ATP release

  খ

  ATP binding

  গ

  GTP hydrolysis

  ঘ

  ATP hydrolysis
• In reality, only one cycle of Hsp protein binding and release helps the target protein to refold.
  ক

  True

  খ

  False
• Which of the following event causes the dissociation of Hsp70 molecules from proteins?
  ক

  Rapid ADP binding after ATP release

  খ

  Slow ATP binding after ADP release

  গ

  Slow ADP binding after ATP release

  ঘ

  Rapid ATP binding after ADP release
• When the Hsp70 bound to proteins hydrolysis the ATP, it undergoes a conformational change. This change causes Hsp70 molecules to perform which of the following activities?
  ক

  No activity at all

  খ

  Cleave the target

  গ

  Dissociate from target

  ঘ

  Associate even more tightly to the target
• The Hsp70 machinery binds to the polypeptide chain after it has left the ribosome.
  ক

  True

  খ

  False