Prediction of Gene Function Based on a Composite Analysis MCQ

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• In Reverse-genetics analysis of gene function– Even though a particular gene may be _____ ortholog of a gene of known function in another organism, that gene may be acquired by a _____ function.
  ক

  a highly predicted, similar

  খ

  a highly predicted, same

  গ

  a highly predicted, novel

  ঘ

  less predicted, novel
• In addition to the care needed in organizing genome databases, a great deal of human input is needed to annotate the genome manually with information.
  ক

  True

  খ

  False
• The ultimate step in genome analysis is to collect the information found on gene and protein sequences, alignments, gene function and location, protein families and domains, relationships of genes to those in other organisms, chromosomal rearrangements, and so on, into a comprehensive database.
  ক

  True

  খ

  False
• A genome database may also be interfaced with other types of data, such as clinical data.
  ক

  True

  খ

  False
• In case of functional genomics– Two general types of approaches are used—one in which a genetic construct is made that interferes with the expression of a particular gene (and sometimes a set of related genes) and a second in which a large number of random mutations are generated in a population of organisms.
  ক

  True

  খ

  False
• Which of the given statement is untrue about functional genomics?
  ক

  Known functions are derived from experimental evidence in molecular biology and genetic studies with model organisms

  খ

  Non-Orthologous genes between biologically distinct species can be identified, and it is strong evidence for a related function

  গ

  Sequence-based methods of gene prediction can be augmented by the types of genome comparisons that are designed to identify related genes based on common patterns of expression, evolutionary profiles, chromosomal locations, and other features

  ঘ

  Genome analysis depends to a large extent on sequence analysis methods that identify gene function based on similarity between proteins of unknown function and proteins of known function
• In Genome-wide prediction of protein functions by a combinatorial method– Each point represents a protein, and branches between proteins indicate a relationship by one of several criteria indicated in the legend.
  ক

  True

  খ

  False
• Other types of evidence for a relationship between two genes are also given that are not dependent in sequence similarity. Which of the following is a wrong statement?
  ক

  genes are closely linked on the same chromosomes

  খ

  genes are transcribed from the same DNA strand

  গ

  gene fusions are observed between otherwise separate genes

  ঘ

  phylogenetic profiles show the genes are not that commonly present in organisms
• When two proteins share a considerable degree of sequence identity throughout the sequence alignment, they are least likely to share the same function.
  ক

  True

  খ

  False