Pharmacology And Toxicology MCQ

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• Which one of the following group is responsible for the duration of the local anesthetic action?
  ক

  Intermediate chain

  খ

  Lipophylic group

  গ

  Ionizable group

  ঘ

  All of the above
• Which of the following can be used as an antidote for atropine?
  ক

  Physostigmine

  খ

  Oxyphenonium

  গ

  Hyoscine butyl bromide

  ঘ

  Propan theline
• Analgesics are
  ক

  CNS depressants

  খ

  Inhalation route

  গ

  SNS stimulants

  ঘ

  Both A and B
• Antihypertensive agent.
  ক

  Amphetamine

  খ

  Adrenaline

  গ

  Salbutamol

  ঘ

  Propranolol
• Select reversible cholinesterase inhibiter
  ক

  Isoflurophate

  খ

  Carbochol

  গ

  Physostigmine

  ঘ

  Parathion
• The half life of insulin of normal subject . . . . . . . . minute
  ক

  15 - 30

  খ

  10 - 15

  গ

  01 - 02

  ঘ

  05 - 06
• What is Pharmacodynamics?
  ক

  Treatment of disease

  খ

  Prevention of disease

  গ

  Interaction of drug with receptor

  ঘ

  Movement of drug through body
• H_b A_1c monitoring of blood is important in which of the given disease condition?
  ক

  C. C. F

  খ

  DM

  গ

  M. I

  ঘ

  Atherosclerosis
• Which effect may lead to toxic reactions when a drug is taken continuously or repeatedly?
  ক

  Refractoriness

  খ

  Cumulative effect

  গ

  Tolerance

  ঘ

  Tachyphylaxis
• The treatment of hormonal deficiencies necessarily implicates the use of . . . . . . . . therapy.
  ক

  Replacement

  খ

  Diffusion

  গ

  Genome

  ঘ

  Transplant
• The mechanism of vigabatrin's action is:
  ক

  Direct action on the GABA receptorchloride channel complex

  খ

  Inhibition of GABA aminotransferase

  গ

  NMDA receptor blockade via the glycine binding site

  ঘ

  Inhibition of GABA neuronal reuptake from synapses
• Which among the following is an antifilarial drug?
  ক

  DEC

  খ

  FNH

  গ

  PAS

  ঘ

  DDS
• Gatifloxacin has been withdrawn from market becuase.
  ক

  Causes renal failure

  খ

  Causes peripheral vascular disease

  গ

  Causes erectile dysfunction

  ঘ

  Hyperglycemia in elderly
• Drug used to test gastric acid secretion
  ক

  Dexamethasone

  খ

  Tyramine

  গ

  Mannitol

  ঘ

  Histamine
• The drug used as an analeptic is
  ক

  Nikethamide

  খ

  Amphetamine

  গ

  Bemegride

  ঘ

  All the above
• . . . . . . . . drug has promising in-vitro and in-vivo activity against strains of Mycobacterium avium Complex.
  ক

  Rifabutin

  খ

  Clarithromycin

  গ

  Azithromycin

  ঘ

  Ciprofloxacin
• . . . . . . . . is found in rich amounts in the neuromuscular junction, postganglionic parasympathetic nerve terminal and ANS ganglia.
  ক

  True choline esterase

  খ

  Butyryl choline esterase

  গ

  Pseudocholine esterase

  ঘ

  Acetylcholinesterase
• All are centrally acting muscle relaxant except:
  ক

  Baclofen

  খ

  Tizanidine

  গ

  Dantrolene

  ঘ

  Benzodiazepine
• Stilboestrol belongs to
  ক

  Synthetic estrogen

  খ

  Semi synthetic estrogen

  গ

  Natural oestrogen

  ঘ

  None of these
• Phenylbutazone is a potent
  ক

  Anti pyretic

  খ

  Anti inflammatory agent

  গ

  Anti septic

  ঘ

  None of the above
• The following Ergot derivative is used for treatment of acute migraine attack
  ক

  Paracetamol

  খ

  Sumatriptan

  গ

  Ergotamine

  ঘ

  Metoclopramide
• Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized:
  ক

  Oral

  খ

  Transdermal

  গ

  Rectal

  ঘ

  Intraduodenal
• Which one is an advantage of oral route of administration?
  ক

  Sometimes complete drug is not absorbed

  খ

  Economical, sterilisation is not required

  গ

  Unpleasant taste of drugs

  ঘ

  Not effective in emergencies
• Potassium sparing diuretics block . . . . . . . . channels in the luminal membrane of the principal cells in the late distal tubule and collecting duct.
  ক

  Na⁺

  খ

  K⁺

  গ

  2Cl^-

  ঘ

  Mg⁺
• Drug prevents mast cells granulation in Asthma is:
  ক

  Ipratropium Br

  খ

  Nedocromil Na

  গ

  Levalbuterol

  ঘ

  Fluticasone
• Presently, Penicillin is obtained from a high yielding mutant of . . . . . . . .
  ক

  P. notatum

  খ

  P. falciparum

  গ

  P. chrysogenum

  ঘ

  T. pallidum
• The therapeutic response to antidepressant drugs is usually over a period of
  ক

  2 - 3 Days

  খ

  2 - 3 Weeks

  গ

  24 Hours

  ঘ

  2 - 3 Month
• Which of the following is the safest anaesthetics?
  ক

  Halothane

  খ

  Ether

  গ

  Cyclopropane

  ঘ

  Nitrous oxide
• Drug administered through the following route is most likely to be subjected to the firstpass metabolism
  ক

  Oral

  খ

  Sublingual

  গ

  Subcutaneous

  ঘ

  Rectal
• What is the effect of strychnine sulphate on spinal cord?
  ক

  Stimulation

  খ

  Depression

  গ

  Contraction

  ঘ

  Relaxation