One & Two Compartment Open Model MCQ

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• In the given picture, the marking “b” represents the drug concentration of which compartment?
  ক

  The central compartment in a two compartment model

  খ

  The peripheral compartment in a two compartment model

  গ

  The central compartment in a one compartment model

  ঘ

  Drug concentration of the plasma
• In the given picture, the marking “a” represents the drug concentration of which compartment?
  ক

  The central compartment in a two compartment model

  খ

  A peripheral compartment in a two compartment model

  গ

  The central compartment in a one compartment model

  ঘ

  Drug concentration of the plasma
• Which of the following is not a category of 2 compartment model?
  ক

  Two compartment model with elimination from the central compartment

  খ

  Two compartment model with elimination from the peripheral compartment

  গ

  Two compartment model with elimination from only plasma and blood

  ঘ

  Two compartment model with elimination from both the compartments
• Which organ comprises the peripheral compartment in a two compartment model?
  ক

  Liver

  খ

  Lungs

  গ

  Kidneys

  ঘ

  Muscles
• Which organs comprise the central compartment in a two compartment model?
  ক

  Muscles

  খ

  Skin

  গ

  Adipose

  ঘ

  Liver
• At which of the four marked points of the plasma drug concentration versus time graph, absorption rate = elimination rate?
  ক

  a

  খ

  b

  গ

  c

  ঘ

  d
• What is the equation to find out hepatic clearance?
  ক

  Plasma drug concentration/rate of elimination by the kidney

  খ

  Rate of elimination by kidney/plasma drug concentration

  গ

  1 / rate of elimination by the kidney

  ঘ

  1 / plasma drug concentration
• To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?
  ক

  1080 ml

  খ

  1080 g

  গ

  1080 mg

  ঘ

  1g/ml
• The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution?
  ক

  625 mg/ml

  খ

  625 l

  গ

  625 ml

  ঘ

  0.0016 mg/ml
• What is the equation to find out the apparent volume of distribution?
  ক

  Amount of drug in the body/plasma drug concentration

  খ

  Plasma drug concentration/amount of drug in the body

  গ

  1 / plasma drug concentration

  ঘ

  1 / Amount of drug in the body
• What is meant by elimination half-life?
  ক

  Time take for half of the amount of drug to get completely eliminated from only the organs

  খ

  Time take for half of the amount of drug to get completely eliminated from only blood

  গ

  Time take for half of the amount of drug to get completely eliminated from only plasma

  ঘ

  Time take for half of the amount of drug to get completely eliminated from the body as well as plasma
• In the equation log C = log Co – KEt/2.303, what does Co stand for _______
  ক

  Plasma drug concentration after 60 min of i.v. injection

  খ

  Plasma drug concentration after 15 min of i.v. injection

  গ

  Plasma drug concentration after 30 min of i.v. injection

  ঘ

  Plasma drug concentration immediately after i.v. injection
• How much time does an intravenously administered drug take to complete a complete circulation?
  ক

  5-8 min

  খ

  7-10 min

  গ

  1-3 min

  ঘ

  1 min
• What does the word “open” mean in the one compartment open model?
  ক

  The drug easily enters

  খ

  The drug readily mixes with the blood

  গ

  Unidirectional input and output

  ঘ

  Easy absorption