Methylation of Eukaryotic DNA Controls Gene Expression MCQ

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• Gene of which of the following protein/enzyme/hormone is an example of paternal Hemizygote?
  ক

  Igf-1

  খ

  Igf-2

  গ

  β-globin

  ঘ

  Insulin
• The phenomenon of allelic exclusion leads to the inactivation of one allele of a gene. The active allele is known as ____________
  ক

  Homozygote

  খ

  Homolog

  গ

  Hemizygote

  ঘ

  Hemilog
• Both the imprinted genes inherited from either parent are expressed in an offspring.
  ক

  True

  খ

  False
• De-novo methylation leads to the phenomenon of genetic imprinting in the offspring.
  ক

  True

  খ

  False
• Major methylation of CpG islands does not include?
  ক

  Operator

  খ

  Terminator

  গ

  Introns

  ঘ

  Enhancer
• The Intergenic CpGs are more commonly methylated than in the intragenetic region.
  ক

  True

  খ

  False
• In humans CpG islands are generally located in the ____________
  ক

  Operator region

  খ

  Promoter region

  গ

  Transcript region

  ঘ

  Terminator region
• The CpG islands generally consist of how many GC bases?
  ক

  100

  খ

  Less than 100

  গ

  More than 1000

  ঘ

  1000
• Methylation of cytosine increases the transition mutation of cytosine to __________
  ক

  Guanine

  খ

  Adenine

  গ

  Thymine

  ঘ

  Adenine and thymine
• Both de-novo methylation and maintenance methylation ensures the methylation pattern is inherited from parent to daughters.
  ক

  True

  খ

  False
• De-novo methylation is done in the newly synthesized DNA strand at opposite positions of the methylated sites on the parent strand.
  ক

  True

  খ

  False
• How many types of methylation processes are known in eukaryotic cells?
  ক

  1

  খ

  2

  গ

  3

  ঘ

  4
• Prokaryotic methylation occurs at ____________
  ক

  AG

  খ

  TC

  গ

  GT

  ঘ

  CA
• The region of maximum methylation in the genome is predominantly activated.
  ক

  True

  খ

  False
• Among the following which shows the maximum rate of cytosine methylation?
  ক

  Insects

  খ

  Worms

  গ

  Animals

  ঘ

  Plants
• Which is known to be methylated in eukaryotic cells?
  ক

  Adenine

  খ

  Guanine

  গ

  Cytosine

  ঘ

  Thymine
• Methylation at which of the following bases is possible within the following oligonucleotides?
  ক

  GAATTC

  খ

  GCGC

  গ

  AGGTTC

  ঘ

  AAGCTT