Mechanism of Action of Glucocorticoids MCQ

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• What is the blood level of corticosteroids in diseased states like renal failure?
  ক

  Increased

  খ

  Decreased

  গ

  Remains the same

  ঘ

  Absent
• Which androgen is converted to 11-oxygenated derivatives of “androsterone” and ‘etiocholanolone?
  ক

  Androsterone

  খ

  DHEA-SO4

  গ

  11-β-OH-androstenedione

  ঘ

  Kinin
• In liver the androgens DHEA and all Δ4-androstenedione are converted to which among the following molecules?
  ক

  Androsterone

  খ

  DHEA-SO4

  গ

  11-β-OH-androstenedione

  ঘ

  Kinin
• Which adrenal androgen is derived from Dehydroepiandrosterone (DHEA)?
  ক

  DHEA-SO4

  খ

  11-β-OH-androstenedione

  গ

  Kinin

  ঘ

  Δ4-androstenedione
• What is the condition of steroids in diseased states like liver cirrhosis?
  ক

  Mineralocorticoids are completely inactivated

  খ

  Glucocorticoids are completely inactivated

  গ

  Mineralocorticoids are not completely inactivated

  ঘ

  Glucocorticoids are not completely inactivated
• What happens in a condition of steroid “resistance” occurring in fibroblasts and lymphoid cells?
  ক

  Decreased sensitivity to steroids

  খ

  Steroids are broken down

  গ

  Steroids are inactivated

  ঘ

  Steroids are activated
• In the nucleus, the DNA binding domain of the glucocorticoid receptor binds to which molecule?
  ক

  Cortisol

  খ

  C terminal proteins

  গ

  Hsp 90

  ঘ

  Hormone responsive element (HRE)
• What causes the dissociation of Hsp 90 heat shock protein that binds to the glucocorticoid receptor?
  ক

  Binding of glucocorticoid

  খ

  Binding of the substrate

  গ

  Binding of ACTH

  ঘ

  Binding of mineralocorticoids
• Which is the heats shock protein that binds to the glucocorticoid receptor when the hormone is absent?
  ক

  Hsp 27

  খ

  Hap 90

  গ

  Hsf 1

  ঘ

  Hsp 90
• In humans there are three types of glucocorticoid receptor proteins.
  ক

  True

  খ

  False
• All of the steroid hormones act initially at the level of cell nucleus.
  ক

  True

  খ

  False
• Which among the following, is a glucocorticoid receptor domain that is present in the N terminal end?
  ক

  Steroid binding domain

  খ

  DNA binding domain

  গ

  Transcription-activating domain

  ঘ

  L domain
• What is the difference between alpha form and beta form of glucocorticoid receptors?
  ক

  Different amino acid sequence in the N-terminal

  খ

  Different amino acid sequence in the C-terminal

  গ

  Different binding substrates

  ঘ

  Difference in the number of domains
• Where is the glucocorticoid receptor protein found in the cell?
  ক

  Cytosol

  খ

  Nucleus

  গ

  Endoplasmic Reticulum

  ঘ

  Ribosomes