Limitations of pH Partition Hypothesis MCQ

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• What are the major stability problems which result in poor bioavailability of any orally administered drugs?
  ক

  Acidic degradation

  খ

  Degradation by salivary amylase

  গ

  Degradation of the drug in inactive form

  ঘ

  Interaction with the excipients and degradation in an inactive form
• Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step.
  ক

  True

  খ

  False
• What will be in the place of ‘?’ in the given picture?
  ক

  Plasma layer

  খ

  Aqueous unstirred diffusion layer

  গ

  Lipid membrane

  ঘ

  Blood vessel
• What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine?
  ক

  More surface area

  খ

  Long residence time

  গ

  Large surface area and long residence time

  ঘ

  Large surface area, long residence time, basic pH
• Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through the intestine.
  ক

  True

  খ

  False
• What helps the ionized drug molecules to pass through the cell membrane passively?
  ক

  Different pH

  খ

  Polar group

  গ

  Large lipophilic group

  ঘ

  Hydration
• According to the pH-partition theory which form of the drug gets absorbed mostly?
  ক

  Hydrated form

  খ

  Aggregated form

  গ

  Ionised

  ঘ

  Unionised
• A microclimate pH, different from the luminal pH exists at the membrane surface.
  ক

  True

  খ

  False
• Which one of these options is not one of the limitations of pH-partition theory?
  ক

  Presence if virtual membrane pH

  খ

  Absorption of ionized drugs

  গ

  Influence of GI surface area

  ঘ

  Dissolution rate