Immunology In Biotechnology MCQ

Test your knowledge with important Immunology In Biotechnology MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30 + more Immunology In Biotechnology MCQs at Bissoy

• Prior exposure of plants to pathogens is known to increase resistance to future pathogen attacks. This phenomenon is known as
  ক

  Systemic acquired resistance

  খ

  Hypersensitive response

  গ

  Innate immunity

  ঘ

  Antibody mediated response
• Lymphocytes interact with foreign antigens in
  ক

  Bone marrow

  খ

  Peripheral blood

  গ

  Thymus

  ঘ

  Lymph nodes
• Protein A, which has strong affinity to Fc region of immunoglobulin, is extracted from
  ক

  Saccharomyces cerevisiae

  খ

  Staphylococcus aureus

  গ

  Streptococcus pyogenes

  ঘ

  Streptococcus sanguis
• Identification of blood groups involves
  ক

  Precipitation

  খ

  Neutralization

  গ

  Opsonization

  ঘ

  Agglutination
• In ABO blood group system, antigenic determinants are
  ক

  Nucleic acid

  খ

  Carbohydrate

  গ

  Lipid

  ঘ

  Protein
• Members of the antibody protein family that have common structural features are collectively known as
  ক

  Haptens

  খ

  Allergens

  গ

  Antigens

  ঘ

  Immunoglobulins
• ABO blood group antigens in humans are differentiated from each other on the basis of
  ক

  Sialic acid

  খ

  Lipids

  গ

  Spectrin

  ঘ

  Glycoproteins
• The polymorphic domains for Class II MHC proteins are
  ক

  α₁ and β₂ domains only

  খ

  β₁ and α₂ domains only

  গ

  α₁ and β₁ domains only

  ঘ

  α₂ and β₂ domains only
• Anergy refers to
  ক

  Mitochondrial dysfunction

  খ

  Allergy to environmental antigens

  গ

  Unresponsiveness to antigens

  ঘ

  A state of no energy
• Which one of the combinations of the following statements is true about antibody structure?<br>P. Limited proteolysis of rabbit IgG with the enzyme pepsin generates two antigen-binding regions (Fab) and an Fc fragment.<br>Q. Limited proteolysis of rabbit IgG with the enzyme papain generates a single bivalent antigen-binding region F(ab')₂ and peptide fragments.<br>R. The Fc fragment of IgG can self-associate and crystallize into a lattice.<br>S. The F(ab')2 fragment of IgG is composed of both light and heavy chains.
  ক

  P and Q only

  খ

  P and R only

  গ

  R and S only

  ঘ

  Q and S only
• Abzymes are
  ক

  Enzymes that are highly specific like antibodies

  খ

  Antibodies that have catalytic activities

  গ

  Also, referred to as zymogens

  ঘ

  Enzymes which hydrolyze antibodies
• Which of these mice fall to develop a thymus?
  ক

  Motheaten mice

  খ

  Beige mice

  গ

  Knock out mice

  ঘ

  Nude mice
• A neonatally thymectomized mouse, immunized with protein antigen shows
  ক

  Both primary and secondary responses to the antigen

  খ

  Only primary response to the antigen

  গ

  Delayed type hypersensitive reactions

  ঘ

  No response to the antigen
• Which one of the following is not a principal component of innate immunity?
  ক

  Mucosal epithelia

  খ

  Dendritic cells

  গ

  Complement system

  ঘ

  Memory B cells
• B-lymphocytes originate from the bone marrow, whereas T lymphocytes originate from
  ক

  Thymus

  খ

  Bone marrow

  গ

  Spleen

  ঘ

  Liver
• Which of the following cytokines are endogenous pyrogens?<br>P. Tumor necrosis factor α<br>Q. Interleukin 1<br>R. Transforming growth factor β<br>S. Interleukin 10
  ক

  P and Q only

  খ

  P and R only

  গ

  R and S only

  ঘ

  Q and S only
• Which one of the following statements is true with regard to processing and presentation of protein antigens?
  ক

  In the class II MHC pathway, protein antigens in the cytosol are processed by proteasomes

  খ

  In the class I MHC pathway, extracellular protein antigens are endocytosed into vesicles and processed

  গ

  In the class I MHC pathway, transporter associated antigen processing (TAP) protein is required for translocating processed peptides generated in the cytosol

  ঘ

  Invariant chain in endoplasmic reticulum is involved in transport of peptides and loading of class I MHC
• Match the autoimmune diseases in Group I with the corresponding primarily affected organ in Group II.<br>
  ক

  <table class="table-style-1"> <tr> <td><strong>Group I</strong></td> <td><strong>Group II</strong></td> </tr> <tr> <td>P. Hashimoto's disease</td> <td>1. Brain</td> </tr> <tr> <td>Q. Juvenile diabetes</td> <td>2. Pancreas</td> </tr> <tr> <td>R. Multiple sclerosis</td> <td>3. Skeletal muscle</td> </tr> <tr> <td>S. Myasthenia gravis</td> <td>4. Thyroid</td> </tr></table> P-1, Q-2, R-3, S-4

  খ

  P-3, Q-1, R-2, S-4

  গ

  P-4, Q-2, R-1, S-3

  ঘ

  P-1, Q-2, R-4, S-3
• A humanized antibody is one in which the
  ক

  Heavy and light chains are from human

  খ

  Heavy chain is from human and light chain is from mouse

  গ

  Light chain is from human and heavy chain is from mouse

  ঘ

  CDRs are from mouse, and the rest is from human
• The first humanized monoclonal antibody approved for the treatment of breast cancer is
  ক

  Rituximab

  খ

  Cetuximab

  গ

  Bevacizumab

  ঘ

  Herceptin
• Match the cells in Group I with their corresponding entries in Group II.<br>
  ক

  <table class="table-style-1"> <tr> <td><strong>Group I</strong></td> <td><strong>Group II</strong></td> </tr> <tr> <td>P. Mast cells</td> <td>1. Activation of the complement pathway</td> </tr> <tr> <td>Q. Natural killer cells</td> <td>2. Expression of CD56</td> </tr> <tr> <td>R. Neutrophils</td> <td>3. Contains azurophilic granules</td> </tr> <tr> <td>S. Dendritic cells</td> <td>4. Defense against helminthic infection</td> </tr><tr> <td></td> <td>5. Production of antibodies specific to bacteria</td> </tr><tr> <td></td> <td>6. Contains long membranous projections</td> </tr></table> P-4, Q-2, R-3, S-5

  খ

  P-4, Q-2, R-3, S-6

  গ

  P-3, Q-1, R-2, S-5

  ঘ

  P-3, Q-1, R-2, S-6
• Heat inactivation of serum is done to inactivate
  ক

  Prions

  খ

  Mycoplasma

  গ

  Complement

  ঘ

  Pathogenic bacteria
• Dizygotic twins are connected to a single placenta during their embryonic development. These twins
  ক

  Have identical MHC haplotypes

  খ

  Have identical T_H cells

  গ

  Have identical T cells

  ঘ

  Can accept grafts from each other (both (A) and (B))
• Which one of the following mechanisms is used by human pathogens to evade host immune responses?
  ক

  Somatic hypermutation

  খ

  Antibody production

  গ

  Antigenic variation

  ঘ

  Complement activation
• Which of the following statement(s) is/are CORRECT for antigen activated effector T cells?<br>P. CD4+ cells make contact with macrophages and stimulate their microbicidal activity.<br>Q. CD4+ cells make contact with B cells and stimulate them to differentiate into plasma cells.<br>R. CD8+ cells make contact with B cells and stimulate them to differentiate into plasma cells.<br>S. CD8+ cells make contact with virus infected cells and kill them.
  ক

  Q only

  খ

  Q and S only

  গ

  P, Q and S only

  ঘ

  P, Q, R and S
• Nude mice refers to
  ক

  Mice without skin

  খ

  Mice without thymus

  গ

  Knockout mice

  ঘ

  Transgenic mice
• Determine the correctness or otherwise of the following Assertion (A) and Reason (R).<br>Assertion: An antigen recognized by one immunoglobulin subtype is not recognized by any other subtype.<br>Reason: Immunoglobulin subtypes differ from each other both in the variable and in the constant regions.
  ক

  Both (A) and (R) are true and (R) is the correct reason for (A)

  খ

  Both (A) and (R) are true but (R) is not the correct reason for (A)

  গ

  Both (A) and (R) are false

  ঘ

  (A) is true but (R) is false
• Endogenous antigens are presented on to the cell surface along with
  ক

  MHC II

  খ

  MHC I

  গ

  F_cγ receptor

  ঘ

  Complement receptor
• The role of an adjuvant is to
  ক

  Prolong the persistence of antigen

  খ

  Cross link the antigen

  গ

  Increase the size of antigen

  ঘ

  Avoid inflammation
• Based on the heavy chain, which one of the following antibodies has multiple subtypes?
  ক

  IgM

  খ

  IgD

  গ

  IgE

  ঘ

  IgG