G Protein-Coupled Receptors - 2 MCQ

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• What is the name of the mechanism in which there are multiple conformations between active and inactive forms of ligands in GPCRs?
  ক

  Ligand directed signalling

  খ

  Receptor directed signalling

  গ

  DNA directed signalling

  ঘ

  RNA directed signalling
• In the 3D structure of a complex between rhodopsin and retinal G protein, C-terminal peptide of the latter binds to which of the amino acids of receptor’s DRY motif?
  ক

  Arginine

  খ

  Lysine

  গ

  Leucine

  ঘ

  Isoleucine
• Which among the following tripeptide is important for G protein activation?
  ক

  Eisenin

  খ

  Peroxide

  গ

  Glutathione

  ঘ

  DRY
• In which place agonist binding of the metabotropic glutamate receptor occurs in the family 3 GPCRs?
  ক

  Between the lobes of the Venus flytrap.

  খ

  Between the C domain

  গ

  Between the DNA binding cleft

  ঘ

  Between the N terminal and C terminal
• After the initial binding to the peptide C-terminus in the family 2 receptors of GPCRs, the extracellular N terminus binds to which of the following domains?
  ক

  DNA binding domain

  খ

  Seven transmembrane domains

  গ

  Ligand domain

  ঘ

  CLB domain
• The N-terminus and extracellular loops of Rhodopsin form a well-structured domain that occludes the site of retinal binding.
  ক

  True

  খ

  False
• Retinal is the ligand of chemokines in GPCRs.
  ক

  True

  খ

  False
• Which among the following terminus is involved in the ligand binding of most of the members of family 1 GPCRs?
  ক

  Extracellular C-terminus

  খ

  Intracellular N-terminus

  গ

  Extracellular N-terminus

  ঘ

  Intracellular C-terminus
• Which among the following is an example of the subset of family 3 of the G protein coupled receptors?
  ক

  Metabotropic glutamate receptor

  খ

  Opsin

  গ

  Chemokine

  ঘ

  FSH
• Which among the following is a distinctive feature of family 3 of the G protein coupled receptors?
  ক

  200-residue C-terminus

  খ

  DNA domain

  গ

  CLB

  ঘ

  Peptide domain