Engineering Therapeutic Hormone : Insulin MCQ

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• Which of the following ion co-ordinates the oligomerization of three insulin dimers to form a hexamer?
  ক

  Sodium ions

  খ

  Calcium ions

  গ

  Copper ions

  ঘ

  Zinc ions
• Which of the following amino acid when inserted in the insulin chain significantly reduces the monomeric interactions?
  ক

  Methionine

  খ

  Valine

  গ

  Glycine

  ঘ

  Glutamic acid
• In Engineered slow-acting insulin (Lantus) the asparagine residue 21 of the A chain is replaced by glycine, and this chain is elongated at its C-terminal end by two arginine residues.
  ক

  True

  খ

  False
• The introduction of amino acid substitutions that will discourage the monomer interaction is to be done inside the insulin receptor binding site.
  ক

  True

  খ

  False
• Which of the following is the trade name of engineered slow-acting insulin?
  ক

  Novorapid

  খ

  Novolog

  গ

  Novolin

  ঘ

  Lantus
• Find the odd one out with respect to engineered fast-acting insulins.
  ক

  Arginine

  খ

  Aspartic acid

  গ

  Histidine

  ঘ

  Valine
• Engineered slow-acting insulin is not fully soluble at which of the following pH?
  ক

  pH 5.5

  খ

  pH 5

  গ

  pH 4

  ঘ

  pH 7
• Which of the following amino acid cannot be inserted to minimize the monomer interactions?
  ক

  Glutamate

  খ

  Arginine

  গ

  Lysine

  ঘ

  Proline
• Which of the following cells are destroyed in type 1 diabetes?
  ক

  Immune cells

  খ

  Gamma cell

  গ

  Alpha cells

  ঘ

  Beta cells
• A combination of fast-acting and slow-acting insulin must usually be administered to diabetics to mimic the natural state.
  ক

  False

  খ

  True
• At physiological concentrations (10-10 M), insulin molecules exist in oligomeric form.
  ক

  True

  খ

  False
• Which of the following consists of a 21 amino acid A-chain linked to a 30 amino acid B chain via two interchain disulfide linkages?
  ক

  Somatostatin

  খ

  Glucagon

  গ

  Hemoglobin

  ঘ

  Insulin
• Which of the following is not true for a healthy person?
  ক

  The pancreas secretes insulin continuously

  খ

  Transient increase in insulin secretion

  গ

  Beta cells secrete insulin

  ঘ

  Insulin is only secreted after a meal
• Which of the following is the main reason for type 2 diabetes?
  ক

  Insulin overproduction

  খ

  Insulin deficiency

  গ

  Insulin destruction

  ঘ

  Insulin resistance