DNA Mutation MCQ

Test your knowledge with important DNA Mutation MCQ and their applications. These MCQs are beneficial for competitive exams too. Explore 30+ more DNA Mutation MCQs on Bissoy. Bissoy App

• Which of this mutagen can lead to both AT->GC and GC->AT transition?
  ক

  Ethydium bromide

  খ

  5 Bromo uracil

  গ

  MMS

  ঘ

  NH2OH
• In an experiment to check mutagenicity of a substance, we feed the mutagen to a rat and then use the rat _______ extract within the media. This ensures_____________
  ক

  Kidney; the mutagen can be at a higher concentration

  খ

  Liver; the media has adequate iron from rat RBC

  গ

  Liver; the mutagen is processed

  ঘ

  Kidney; the mutagen is broken down
• In Ames test, the bacterial culture are grown in _________
  ক

  Natural media

  খ

  Blood agar

  গ

  Enriched media

  ঘ

  Minimal media
• Which of the following mutation will lead to AT->GC transition?
  ক

  Nitrous acid acting on A

  খ

  Nitrous acid on C

  গ

  Hydroxylation of C

  ঘ

  Methylation of G
• Reverse and suppressor mutations both result in wild phenotype. Thus they are both indistinguishable by any test performed on phenotype.
  ক

  True

  খ

  False
• Which of the mutations can be detected Phenotypically?
  ক

  Silent

  খ

  Neutral

  গ

  Reverse

  ঘ

  Sense
• Which of the following agents can lead to both addition and deletion mutation?
  ক

  UV

  খ

  5 Bromo Uracil

  গ

  Proflavin

  ঘ

  Hydroxylation
• Deamination of which of the bases which nitrous acid will not lead to any change in the base pairing?
  ক

  A

  খ

  G

  গ

  C

  ঘ

  T
• 5 Bromo uracil can pair with _____________
  ক

  Uracil

  খ

  Thymine

  গ

  Guanine

  ঘ

  Cytosine
• You are studying a mutational hot spot in the promoter region of a gene. Which type of mutation will you expect the most in this case?
  ক

  Deamination

  খ

  Depurination

  গ

  Methylation

  ঘ

  Frame shift
• In an experiment your germ cell was having a base at its unusual tautomeric state while replication. What could be the maximum percentage of germ cells carrying this mutation?
  ক

  All

  খ

  25%

  গ

  50%

  ঘ

  75%
• The normal form for A and C, and G and T are _____________
  ক

  Imino and Keto

  খ

  Imino and Enol

  গ

  Amino and Enol

  ঘ

  Amino and Keto
• Which sequences among these will have a preference for frame shift?
  ক

  TTTTTTTTTTTTTTT

  খ

  AUGATTCT

  গ

  CATGCATGCATG

  ঘ

  AUGCTGTCGUA
• Which of the following can act as an intragenic suppressor mutation to a Frame shift mutation?
  ক

  Transition

  খ

  Missense mutation

  গ

  Another frame shift mutation

  ঘ

  Non sense mutation
• Which of the following is a result of a sense mutation?
  ক

  Sickle cell anemia

  খ

  Thalassemia

  গ

  Mutation in beta globin leading to abnormal clotting and bleeding

  ঘ

  Down’s syndrome
• Which of the following is a neutral mutation?
  ক

  Replacement of a Glu by Val

  খ

  Replacement of AAA by UAA

  গ

  Replacement of Lys by Arg

  ঘ

  Replacement of Thr by Tyr
• Wooble base recognition of the tRNAs in translation ignores which of the mutation?
  ক

  Frame shift

  খ

  Neutral

  গ

  Silent

  ঘ

  Sense
• A frame shift mutation will have minimum effect when it leads to ______________
  ক

  Insertion of 2 bases

  খ

  Deletion of 1 base

  গ

  Insertion of 3 bases

  ঘ

  Deletion of 2 bases
• Sickle cell anemia is a result of _______________
  ক

  Non sense mutation

  খ

  Mis-sense mutation

  গ

  Sense mutation

  ঘ

  Frame shift mutation
• Total number of transition and transversion that can take place in genome is___________
  ক

  2 and 6

  খ

  6 and 4

  গ

  4 and 6

  ঘ

  4 and 8
• The number of times a particular mutation occurs in a population of cells or individuals is known as __________
  ক

  Mutation rate

  খ

  Mutation frequency

  গ

  Mutation count

  ঘ

  Mutation efficiency
• Which of the following harmful mutations will have the most severe effect in the progeny?
  ক

  Mutation in a muscle tissue

  খ

  Mutation in a gamete

  গ

  Mutation in sperm mother cells

  ঘ

  Mutation in mammary gland tissue
• ‘Delicious apples’ can’t be propagated through_____________
  ক

  Stem

  খ

  Leaf

  গ

  Seed

  ঘ

  Tissue culture
• Which of the following is not a point mutation?
  ক

  Substitution

  খ

  Transposition

  গ

  Insertion

  ঘ

  Transversion
• All mutations result in the production of a mutant.
  ক

  True

  খ

  False